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Protein

Hypoxia up-regulated protein 1

Gene

hyou1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxia up-regulated protein 1
Gene namesi
Name:hyou1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-921821. hyou1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 643621Hypoxia up-regulated protein 1PRO_0000379423Add
BLAST

Proteomic databases

PaxDbiQ0VA61.
PRIDEiQ0VA61.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000022209.

Structurei

3D structure databases

ProteinModelPortaliQ0VA61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi627 – 6304Poly-Glu

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0104. Eukaryota.
COG0443. LUCA.
HOGENOMiHOG000007865.
InParanoidiQ0VA61.
KOiK09486.

Family and domain databases

Gene3Di2.60.34.10. 2 hits.
InterProiIPR018181. Heat_shock_70_CS.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VA61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLVCVFTM FLLALLSSNT ESVAVMSVDM GSEWMKIAIV KPGVPMEIVL
60 70 80 90 100
NKESRRKTPV AIALKENERL FGDSALGMAV KNPKVTFRYF QDLLGKRADN
110 120 130 140 150
PHVKAFEARF PEYQLVKDEH RETVLFKLSE ELTYSPEELL GMMLNYSRSL
160 170 180 190 200
AEEFAEQPVK DVVITVPAFF NQAERRAVLQ AAQLSDLKVL QLINDNTAVA
210 220 230 240 250
LNYGVFRRKD INATAQNIMF YEMGSRSTIC TIVTYQSVKT KDSGMQPQLQ
260 270 280 290 300
IRGVGFDRTL GGIEMDLRLR DHLAKLFNEQ KKSKKDVREN QRAMSKLLKE
310 320 330 340 350
ANRVKTILSA NNDHMAQIEG LMDDIDFKAK VTRQELEDLC ADLFNRVSAP
360 370 380 390 400
VQHALSSAEM KMEEIDQVIL VGGATRVPKV QELLLKVVGK EELGKNINAD
410 420 430 440 450
EAAAMGAVYQ AAALSKAFKV KPFIVRDAAI FPIQVEFTRE VEEEDHSKSL
460 470 480 490 500
KHNKRILFQR LAPYPQRKVI TFNRYTDNFA FSINYGDLSY LGPDDLKVFG
510 520 530 540 550
SLNLTTVKLN GVGESFQKRS DYESKGIKAH FNMDESGLLT LDRVEAVFET
560 570 580 590 600
VVDEKPEQES TLTKLGNTIS SLFGGGSSVP ETKENATDSV QEEDEVPTEP
610 620 630 640
TKEEEQESAD AADKQKDKEK GTTATNEEEE GKKEEEKSEP QEE
Length:643
Mass (Da):72,301
Last modified:July 7, 2009 - v2
Checksum:iC18F59C40E71BB01
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei643 – 6431

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121233 mRNA. Translation: AAI21234.1. Different termination.
RefSeqiNP_001263614.1. NM_001276685.2.
NP_001263615.1. NM_001276686.1.
UniGeneiStr.55584.

Genome annotation databases

GeneIDi779444.
KEGGixtr:779444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121233 mRNA. Translation: AAI21234.1. Different termination.
RefSeqiNP_001263614.1. NM_001276685.2.
NP_001263615.1. NM_001276686.1.
UniGeneiStr.55584.

3D structure databases

ProteinModelPortaliQ0VA61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000022209.

Proteomic databases

PaxDbiQ0VA61.
PRIDEiQ0VA61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi779444.
KEGGixtr:779444.

Organism-specific databases

CTDi10525.
XenbaseiXB-GENE-921821. hyou1.

Phylogenomic databases

eggNOGiKOG0104. Eukaryota.
COG0443. LUCA.
HOGENOMiHOG000007865.
InParanoidiQ0VA61.
KOiK09486.

Family and domain databases

Gene3Di2.60.34.10. 2 hits.
InterProiIPR018181. Heat_shock_70_CS.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYOU1_XENTR
AccessioniPrimary (citable) accession number: Q0VA61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 7, 2009
Last modified: November 11, 2015
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.