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Q0VA45 (ZYX_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Zyxin
Gene names
Name:zyx
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length674 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Adhesion plaque protein. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression. Suppresses the transcription-repressing activity of hesx1/anf1 By similarity. UniProtKB Q04584 UniProtKB A5H447

Subunit structure

Interacts (via LIM2 domain) with hesx1/anf1 By similarity.

Subcellular location

Cytoplasm By similarity. Cytoplasm › cytoskeleton By similarity. Cell junction › focal adhesion By similarity. Note: Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of hesx1 By similarity. UniProtKB Q04584 UniProtKB Q15942

Sequence similarities

Belongs to the zyxin/ajuba family.

Contains 3 LIM zinc-binding domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 674674Zyxin
PRO_0000331488

Regions

Domain481 – 54262LIM zinc-binding 1
Domain543 – 60058LIM zinc-binding 2
Domain601 – 67171LIM zinc-binding 3
Compositional bias21 – 344324Pro-rich

Sequences

Sequence LengthMass (Da)Tools
Q0VA45 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: BDAA9997C66575C4

FASTA67471,365
        10         20         30         40         50         60 
MDPAAPAARM TSSFTINIST PSFYNPPKKF APVVPPKPKV NPFRAAEEPV PQENSAGPGL 

        70         80         90        100        110        120 
RRAFVGKVGQ IPSMAPPGGD PEDFVLPPPP PNEEPMSPPG SSFPPPPPSF GDDGPGSPLG 

       130        140        150        160        170        180 
LFPPPPPPEF SEPFPPPIEE SFPSPPPLEE AAGLSDTQDP PASVPPPPPP LPSPPEPAPP 

       190        200        210        220        230        240 
VLCEAPKPAP VLPKPPPPSA FPKPEPPQSV APKAQSSIFI PKPSPPSAVA PKPVAPPPVA 

       250        260        270        280        290        300 
AKPSGPGPFV GPSAAPPTHT PAPPAPAHTF SPKPVAGPTF APKSASHTFM AKPSAPVFSP 

       310        320        330        340        350        360 
KAATEPPTEA PQERFPASQS SPKLTPAAKH EAPPPAAKHE APPPASATRA PGFSFAQQRD 

       370        380        390        400        410        420 
KPRVLEKPRA NVRDLVPEPP VETRGERTLG PQAEGGRSFG AQPIGGKDTK PLPEGLRNQT 

       430        440        450        460        470        480 
PDGTHRVGGQ PGTHRPTPHQ DQTSGSQGLN MKEVEELEML TQQLMQEMDK PTPAAEAHTM 

       490        500        510        520        530        540 
ELCGFCGRGL SRTETVVRAG EHLYHVTCFT CSKCEQQLQG QQYYESAGKP LCEECYQDTL 

       550        560        570        580        590        600 
ECCAVCEKKI TERLLRAIGQ AYHPSCFTCA VCKCSLQGEP FIVDDNKLPH CVSDYHRRYA 

       610        620        630        640        650        660 
PRCTVCGDPI APEPGRDETV RVVALEKNFH MMCYKCEDCG CPLSIEADDG GCFPLDGHVL 

       670 
CKKCHTVRAR AALG

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC121255 mRNA. Translation: AAI21256.1.
RefSeqNP_001072265.1. NM_001078797.1.
UniGeneStr.45714.

3D structure databases

ProteinModelPortalQ0VA45.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID779718.
KEGGxtr:779718.

Organism-specific databases

CTD7791.
XenbaseXB-GENE-6453993. zyx.

Phylogenomic databases

HOVERGENHBG108781.
KOK06273.

Family and domain databases

Gene3D2.10.110.10. 3 hits.
InterProIPR001781. Znf_LIM.
[Graphical view]
PfamPF00412. LIM. 3 hits.
[Graphical view]
SMARTSM00132. LIM. 3 hits.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameZYX_XENTR
AccessionPrimary (citable) accession number: Q0VA45
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 5, 2006
Last modified: April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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