Q0VA39 (GALC_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactocerebrosidase
Short name=GALCERase
EC=3.2.1.46

Alternative name(s):
Galactosylceramidase

Gene names

Name:

galc

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	678 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride By similarity.
Catalytic activity	D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.
Subcellular location	Lysosome By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 59 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro galactosylceramide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cation binding Inferred from electronic annotation. Source: InterPro galactosylceramidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 678	645	Galactocerebrosidase		PRO_0000370716
Amino acid modifications
	Glycosylation	292	1	N-linked (GlcNAc...) Potential
	Glycosylation	371	1	N-linked (GlcNAc...) Potential
	Glycosylation	382	1	N-linked (GlcNAc...) Potential
	Glycosylation	395	1	N-linked (GlcNAc...) Potential
	Glycosylation	425	1	N-linked (GlcNAc...) Potential
	Glycosylation	442	1	N-linked (GlcNAc...) Potential
	Glycosylation	510	1	N-linked (GlcNAc...) Potential
	Glycosylation	550	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0VA39 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 9A8DC79F7C3ED6CB	FASTA	678	75,833
	10 20 30 40 50 60 MRTVLAGSRR APGCGEGMFI LWLVLLLFPG APAQYSVDDL GGLGRMFDGI GAISGGGATS 70 80 90 100 110 120 RLLVNYPEPQ RTEILDYLFK PNFGASLHIF KVEIGGDAQT TDGTEPSHMH YPDDQNYFRG 130 140 150 160 170 180 YEWWLMKEAK KRNPAIKLIG LPWAFPGWIG NGKNWPYDFP DVTAYYVVSW IIGAKQYHNL 190 200 210 220 230 240 DIDYIGIWNE RAYDIKYIKL LRYTLDKNNL EHVKIIASDN LWQPIAFHML QDPELLRVVD 250 260 270 280 290 300 VIGAHYPGTH AAQDAILTGK TLWASEDYST YNDEVGGGCW ARILNQNYVN GNMTSTISWN 310 320 330 340 350 360 MVASYYEQLP FGLEGLMTAK EPWSGNYVVS TPIWITAHTT QFTQPGWYYL KTVGHLDKGG 370 380 390 400 410 420 SYVALTDRLG NLTIVIETMS HNNSICIRPP LPDYNVSAQY ATFYLQGSFK NLQELQVWYS 430 440 450 460 470 480 SLDINNTKPV TFKKLSPLKV QNGSFTLQLG VNEVYTITTL LTGQKGSFPD PPESKPFPLK 490 500 510 520 530 540 YKDDFSVRNP PFSEAPYFAD QSGVFEYFTN TSDPGDHVFT FRQVLTQRPI TWASDANQAI 550 560 570 580 590 600 SVIGNYQWSN VTVTSDIYIE TPDTGGVFVA ARVDQGGSPT DRAKGIFFWV FADGTYKVTG 610 620 630 640 650 660 DLMGQTILCK GLAGVRARSW HTLTLHIDGT NAFGLLNGNP LWKEVVTGGP LNGWAAIGTS 670 CFEFAQFDNF MIEVKDSE

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC121269 mRNA. Translation: AAI21270.1.
RefSeq	NP_001072270.1. NM_001078802.1.
UniGene	Str.13689.
3D structure databases
ProteinModelPortal	Q0VA39.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0VA39.
Protein family/group databases
CAZy	GH59. Glycoside Hydrolase Family 59.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	779723.
KEGG	xtr:779723.
Organism-specific databases
CTD	2581.
Xenbase	XB-GENE-1000107. galc.
Phylogenomic databases
eggNOG	veNOG05321.
GeneTree	ENSGT00390000003303.
Gene expression databases
Bgee	Q0VA39.
Family and domain databases
InterPro	IPR001286. Glyco_hydro_59. IPR013781. Glyco_hydro_subgr_catalytic. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
KO	K01202.
PANTHER	PTHR15172. Glyco_hydro_59. 1 hit.
Pfam	PF02057. Glyco_hydro_59. 1 hit. [Graphical view]
PRINTS	PR00850. GLHYDRLASE59.
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GALC_XENTR

Accession

Primary (citable) accession number: Q0VA39

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	September 5, 2006
Last modified:	November 16, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program