Reviewed, UniProtKB/Swiss-Prot Q0V9S0 (SYTC2_XENTR)

Names and origin

Protein names

Recommended name:
    Probable threonyl-tRNA synthetase 2, cytoplasmic
    EC=6.1.1.3
Alternative name(s):
    Threonine--tRNA ligase
      Short name=ThrRS
    Threonyl-tRNA synthetase-like protein 2

Gene names

Name:

tarsl2

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	814 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Gene Ontology (GO)
Biological process	threonyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW threonine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 814	814	Probable threonyl-tRNA synthetase 2, cytoplasmic		PRO_0000333830
Regions
	Coiled coil	2 – 72	71	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0V9S0-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 97A63139DAEE7562	FASTA	814	93,328
	10 20 30 40 50 60 MAAHIAQRLT VQEQEIRRLN EEIGRLLELG LQGSVEHSPN PVLEQLRAEN EKLKYRISHL 70 80 90 100 110 120 QRSLREEQER ARPGQYGEPG LKDAAPVEEP KQQNNKAKEK GQATKGENSV GGKPSACEGN 130 140 150 160 170 180 KKNEKKAGKE VDGHKQEGPC APGFIKDRLA LYETLKNEHD ALLAARAAHQ SKPIKITLAD 190 200 210 220 230 240 GKQVDGESWK TTPYQVAIGI SKGLADNVVI AKVNNELWDL DRPLEQDSNV ELLKFDSEEA 250 260 270 280 290 300 QAVYWHSSAH ILGETMENFY GGCLCYGPPI ENGFYYDMYL DGRGVSSNEF PSLENMCKAI 310 320 330 340 350 360 IKEKQPFERL EVSKDLLLEM FKYNKFKCRI LNEKVDTPTT TVYRCGPLID LCRGPHVRHT 370 380 390 400 410 420 GKIKTLKIYK NSSTYWEGRA DMETLQRIYG ISFPDSKLMK EWEQFQEEAK NRDHRKIGRD 430 440 450 460 470 480 QELFFFHDLS PGSCFFLPRG AHIYNTLTDF IKGEYQIRNF TEVASPNIYN SKLWEMSGHW 490 500 510 520 530 540 QHYSENMFSF EVEKETFALK PMNCPGHCLM FGHRPRSWRE LPLRFADFGV LHRNELSGTL 550 560 570 580 590 600 SGLTRVRRFQ QDDAHIFCTM DQIQEEMNGC LQFLQSVYKV FGFTFQLHLS TRPENYLGEI 610 620 630 640 650 660 EIWNEAEKQL ESSLNQFGEP WKLNPGDGAF YGPKIDIKIK DAIGRYHQCA TIQLDFQLPI 670 680 690 700 710 720 RFNLTYVSKD GDDKKRPVII HRAILGSVER MIAILCENYG GKWPFWLSPR QVMVIPVGPS 730 740 750 760 770 780 CDEYAQQVCK DVFEAGFMAE VDLDHSCTLN KKIRNAQLAQ CNFILVVGEK EKTDSAVNVR 790 800 810 TRDNKVHGEI LLTSAIEKLK TLKKLRSKNA EEEF

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC121417 mRNA. Translation: AAI21418.1.
RefSeq	NP_001096223.1.
UniGene	Str.31543
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0V9S0.
Genome annotation databases
GeneID	100124774.
KEGG	xtr:100124774.
Organism-specific databases
Xenbase	XB-FEAT-5954361. tarsl2.
Phylogenomic databases
HOVERGEN	Q0V9S0.
Family and domain databases
InterPro	IPR002314. aa-tRNA-synt_IIb_cons-reg. IPR006195. aa-tRNA-synth_II_cons-reg. IPR004154. Anticodon_bd. IPR012675. b-grasp_ferredoxin-like. IPR004095. TGS. IPR002320. Thr-tRNA-synth_IIa. IPR018158. Thr-tRNA-synth_IIa_cons-reg. IPR012947. tRNA_SAD. [Graphical view]
Gene3D	G3DSA:3.40.50.800. Anticodon_bd. 1 hit. G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
Pfam	PF03129. HGTP_anticodon. 1 hit. PF02824. TGS. 1 hit. PF00587. tRNA-synt_2b. 1 hit. PF07973. tRNA_SAD. 1 hit. [Graphical view]
PRINTS	PR01047. TRNASYNTHTHR.
TIGRFAMs	TIGR00418. thrS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYTC2_XENTR

Accession

Primary (citable) accession number: Q0V9S0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	September 5, 2006
Last modified:	October 13, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project