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Q0V9P1 (HNMT_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histamine N-methyltransferase

Short name=HMT
EC=2.1.1.8
Gene names
Name:hnmt
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.

Catalytic activity

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistamine N-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293Histamine N-methyltransferase
PRO_0000271428

Sites

Binding site281Substrate By similarity
Binding site601S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site891S-adenosyl-L-methionine By similarity
Binding site941S-adenosyl-L-methionine By similarity
Binding site1201S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding site1421S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site2831Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0V9P1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 29F7F721066A09BB

FASTA29333,115
        10         20         30         40         50         60 
MDSGLRSLLS DHSRYVESFR LFLLNSTEHQ CMQRFIDTQF PHIVSSIGKD KSVIDILGIG 

        70         80         90        100        110        120 
SGSGEIDLQM IGKIQSRHPG VAISNQIVEP SAEQIIGYKE RVAKAPNLGA VSFSWHRQTS 

       130        140        150        160        170        180 
SEYERQVNEE KQMRSYDFIH MIQMLYYVKD VPATLRFFKS CLAPNGKLLI ILVSGNSGWS 

       190        200        210        220        230        240 
MLWKKHGPQL PLNDLCLYVT AGDIAQMLSS MGARFQSYEL PSDMDITECF IEGDRNGEML 

       250        260        270        280        290 
LDFLTETCDF KRNAPADLRE QILCDLKSPE CSTTRDGKVI FNNNLSVIVV ERD 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC121451 mRNA. Translation: AAI21452.1.
RefSeqNP_001072355.1. NM_001078887.1.
UniGeneStr.53540.

3D structure databases

ProteinModelPortalQ0V9P1.
SMRQ0V9P1. Positions 5-291.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000032543.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID779808.
KEGGxtr:779808.

Organism-specific databases

CTD3176.
XenbaseXB-GENE-1001069. hnmt.

Phylogenomic databases

eggNOGNOG39680.
HOGENOMHOG000231790.
HOVERGENHBG051914.
KOK00546.

Family and domain databases

InterProIPR016673. Histamine_N-methyltransferase.
[Graphical view]
PANTHERPTHR32330:SF0. PTHR32330:SF0. 1 hit.
PIRSFPIRSF016616. HHMT. 1 hit.
PROSITEPS51597. SAM_HNMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHNMT_XENTR
AccessionPrimary (citable) accession number: Q0V9P1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 5, 2006
Last modified: October 16, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families