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Q0V9P1

- HNMT_XENTR

UniProt

Q0V9P1 - HNMT_XENTR

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Protein
Histamine N-methyltransferase
Gene
hnmt
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.

Catalytic activityi

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281Substrate By similarity
Binding sitei60 – 601S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei89 – 891S-adenosyl-L-methionine By similarity
Binding sitei94 – 941S-adenosyl-L-methionine By similarity
Binding sitei120 – 1201S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding sitei142 – 1421S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei283 – 2831Substrate By similarity

GO - Molecular functioni

  1. histamine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine N-methyltransferase (EC:2.1.1.8)
Short name:
HMT
Gene namesi
Name:hnmt
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1001069. hnmt.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Histamine N-methyltransferase
PRO_0000271428Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi8364.ENSXETP00000032543.

Structurei

3D structure databases

ProteinModelPortaliQ0V9P1.
SMRiQ0V9P1. Positions 5-291.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG39680.
HOGENOMiHOG000231790.
HOVERGENiHBG051914.
KOiK00546.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PIRSFiPIRSF016616. HHMT. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51597. SAM_HNMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0V9P1-1 [UniParc]FASTAAdd to Basket

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MDSGLRSLLS DHSRYVESFR LFLLNSTEHQ CMQRFIDTQF PHIVSSIGKD    50
KSVIDILGIG SGSGEIDLQM IGKIQSRHPG VAISNQIVEP SAEQIIGYKE 100
RVAKAPNLGA VSFSWHRQTS SEYERQVNEE KQMRSYDFIH MIQMLYYVKD 150
VPATLRFFKS CLAPNGKLLI ILVSGNSGWS MLWKKHGPQL PLNDLCLYVT 200
AGDIAQMLSS MGARFQSYEL PSDMDITECF IEGDRNGEML LDFLTETCDF 250
KRNAPADLRE QILCDLKSPE CSTTRDGKVI FNNNLSVIVV ERD 293
Length:293
Mass (Da):33,115
Last modified:September 5, 2006 - v1
Checksum:i29F7F721066A09BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC121451 mRNA. Translation: AAI21452.1.
RefSeqiNP_001072355.1. NM_001078887.1.
UniGeneiStr.53540.

Genome annotation databases

GeneIDi779808.
KEGGixtr:779808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC121451 mRNA. Translation: AAI21452.1 .
RefSeqi NP_001072355.1. NM_001078887.1.
UniGenei Str.53540.

3D structure databases

ProteinModelPortali Q0V9P1.
SMRi Q0V9P1. Positions 5-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000032543.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 779808.
KEGGi xtr:779808.

Organism-specific databases

CTDi 3176.
Xenbasei XB-GENE-1001069. hnmt.

Phylogenomic databases

eggNOGi NOG39680.
HOGENOMi HOG000231790.
HOVERGENi HBG051914.
KOi K00546.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PIRSFi PIRSF016616. HHMT. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51597. SAM_HNMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiHNMT_XENTR
AccessioniPrimary (citable) accession number: Q0V9P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 5, 2006
Last modified: June 11, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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