Reviewed, UniProtKB/Swiss-Prot Q0V9P1 (HNMT_XENTR)

Names and origin

Protein names

Recommended name:
    Histamine N-methyltransferase
      Short name=HMT
    EC=2.1.1.8

Gene names

Name:

hnmt

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.
Catalytic activity	S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the methyltransferase superfamily. HNMT family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histamine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Histamine N-methyltransferase		PRO_0000271428
Sites
	Binding site	28	1	Substrate By similarity
	Binding site	60	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	89	1	S-adenosyl-L-methionine By similarity
	Binding site	94	1	S-adenosyl-L-methionine By similarity
	Binding site	120	1	S-adenosyl-L-methionine; via amide nitrogen By similarity
	Binding site	142	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	283	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0V9P1-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 29F7F721066A09BB	FASTA	293	33,115
	10 20 30 40 50 60 MDSGLRSLLS DHSRYVESFR LFLLNSTEHQ CMQRFIDTQF PHIVSSIGKD KSVIDILGIG 70 80 90 100 110 120 SGSGEIDLQM IGKIQSRHPG VAISNQIVEP SAEQIIGYKE RVAKAPNLGA VSFSWHRQTS 130 140 150 160 170 180 SEYERQVNEE KQMRSYDFIH MIQMLYYVKD VPATLRFFKS CLAPNGKLLI ILVSGNSGWS 190 200 210 220 230 240 MLWKKHGPQL PLNDLCLYVT AGDIAQMLSS MGARFQSYEL PSDMDITECF IEGDRNGEML 250 260 270 280 290 LDFLTETCDF KRNAPADLRE QILCDLKSPE CSTTRDGKVI FNNNLSVIVV ERD

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC121451 mRNA. Translation: AAI21452.1.
RefSeq	NP_001072355.1.
UniGene	Str.53540
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	779808.
KEGG	xtr:779808.
Organism-specific databases
Xenbase	XB-FEAT-1001068. hnmt.
Phylogenomic databases
HOVERGEN	Q0V9P1.
Enzyme and pathway databases
BRENDA	2.1.1.8. 279072.
Family and domain databases
InterPro	IPR016673. Histamine_N-methyltransferase. [Graphical view]
PIRSF	PIRSF016616. HHMT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HNMT_XENTR

Accession

Primary (citable) accession number: Q0V9P1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project