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Protein

Histamine N-methyltransferase

Gene

hnmt

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281SubstratePROSITE-ProRule annotation
Binding sitei60 – 601S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei89 – 891S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei94 – 941S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei120 – 1201S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
Binding sitei142 – 1421S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei283 – 2831SubstratePROSITE-ProRule annotation

GO - Molecular functioni

  1. histamine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine N-methyltransferase (EC:2.1.1.8)
Short name:
HMT
Gene namesi
Name:hnmt
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1001069. hnmt.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Histamine N-methyltransferasePRO_0000271428Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000032543.

Structurei

3D structure databases

ProteinModelPortaliQ0V9P1.
SMRiQ0V9P1. Positions 5-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG39680.
HOGENOMiHOG000231790.
HOVERGENiHBG051914.
InParanoidiQ0V9P1.
KOiK00546.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PIRSFiPIRSF016616. HHMT. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51597. SAM_HNMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0V9P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSGLRSLLS DHSRYVESFR LFLLNSTEHQ CMQRFIDTQF PHIVSSIGKD
60 70 80 90 100
KSVIDILGIG SGSGEIDLQM IGKIQSRHPG VAISNQIVEP SAEQIIGYKE
110 120 130 140 150
RVAKAPNLGA VSFSWHRQTS SEYERQVNEE KQMRSYDFIH MIQMLYYVKD
160 170 180 190 200
VPATLRFFKS CLAPNGKLLI ILVSGNSGWS MLWKKHGPQL PLNDLCLYVT
210 220 230 240 250
AGDIAQMLSS MGARFQSYEL PSDMDITECF IEGDRNGEML LDFLTETCDF
260 270 280 290
KRNAPADLRE QILCDLKSPE CSTTRDGKVI FNNNLSVIVV ERD
Length:293
Mass (Da):33,115
Last modified:September 4, 2006 - v1
Checksum:i29F7F721066A09BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121451 mRNA. Translation: AAI21452.1.
RefSeqiNP_001072355.1. NM_001078887.1.
UniGeneiStr.53540.

Genome annotation databases

GeneIDi779808.
KEGGixtr:779808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121451 mRNA. Translation: AAI21452.1.
RefSeqiNP_001072355.1. NM_001078887.1.
UniGeneiStr.53540.

3D structure databases

ProteinModelPortaliQ0V9P1.
SMRiQ0V9P1. Positions 5-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000032543.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi779808.
KEGGixtr:779808.

Organism-specific databases

CTDi3176.
XenbaseiXB-GENE-1001069. hnmt.

Phylogenomic databases

eggNOGiNOG39680.
HOGENOMiHOG000231790.
HOVERGENiHBG051914.
InParanoidiQ0V9P1.
KOiK00546.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PIRSFiPIRSF016616. HHMT. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51597. SAM_HNMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiHNMT_XENTR
AccessioniPrimary (citable) accession number: Q0V9P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 8, 2007
Last sequence update: September 4, 2006
Last modified: January 6, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.