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Q0V9G5

- UBP44_XENTR

UniProt

Q0V9G5 - UBP44_XENTR

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Protein

Ubiquitin carboxyl-terminal hydrolase 44

Gene
usp44
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Deubiquitinase that plays a key role in the spindle checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei283 – 2831Nucleophile By similarity
Active sitei639 – 6391Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri24 – 8562UBP-typeAdd
BLAST

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB
  2. ubiquitin thiolesterase activity Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. anaphase Source: UniProtKB
  2. mitotic nuclear division Source: UniProtKB-KW
  3. negative regulation of mitotic anaphase-promoting complex activity Source: UniProtKB
  4. protein deubiquitination Source: UniProtKB
  5. regulation of spindle checkpoint Source: UniProtKB
  6. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 44 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 44
Ubiquitin thioesterase 44
Ubiquitin-specific-processing protease 44
Gene namesi
Name:usp44
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1014112. usp44.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 652652Ubiquitin carboxyl-terminal hydrolase 44PRO_0000395815Add
BLAST

Proteomic databases

PaxDbiQ0V9G5.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000020288.

Structurei

3D structure databases

ProteinModelPortaliQ0V9G5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini274 – 652379USPAdd
BLAST

Sequence similaritiesi

Contains 1 USP domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri24 – 8562UBP-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000015084.
HOVERGENiHBG018027.
KOiK11834.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0V9G5-1 [UniParc]FASTAAdd to Basket

« Hide

MDKCKHVGRL RLAQDHSILN PQKWHCVDCN TTESVWACLS CSHVACGRYI    50
EEHALRHFQD SKHPLALEVN ELYVFCYLCD DYVLNDNTTG DLKLLRSTLS 100
AIKSQNYDCT TRSGRTLRSM VTADDSFISH EGAQAFLQNE DRAFTALWHR 150
RHALLGKVFR SWFALTPKGK QRLEEERLRE VAEQKREEAR KRRQQLKRKL 200
KEEMESTPPR KSSRLKQQMQ PSPKTELPSV QKMNQKYTPT TKQKPPAPTS 250
IEVCLKKIGN SPIKRKPTVT PGVTGLRNLG NTCYMNSILQ ILSHLHVFRE 300
CFLQLDLNQT QELLAAAGSG KTRLSSKYPP SAVLPKVTQK HTKVQRSLAR 350
RQSFSSGLSG GASNSRNMEL IQPKEPSSKH ISLCHELHTL FQVMWSGKWA 400
LVSPFAMLHS VWRLIPAFRG YAQQDAQEFL CELLDKVQQE LETTGTRYPT 450
LIPASQRKLI KQVLNIVNNI FHGQLLSQVT CLACDHKSNT IEPFWDLSLE 500
FPERYHFNGK ETASQRPCLL TEMLAKFTET EALEGKIYAC DQCNTKRRKF 550
SSKPVVLTEA QKQLMVCRLP QVLRLHLKRF RWSGRNHREK IGVHVRFDQM 600
LNMEPYCCRE STAALRADCF IYDLSSVVMH HGKGFGSGHY TAFCYNPEGG 650
NG 652
Length:652
Mass (Da):74,676
Last modified:September 5, 2006 - v1
Checksum:iA95E03024EA2AF44
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC121579 mRNA. Translation: AAI21580.1.
RefSeqiNP_001072389.1. NM_001078921.1.
UniGeneiStr.5094.

Genome annotation databases

GeneIDi779843.
KEGGixtr:779843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC121579 mRNA. Translation: AAI21580.1 .
RefSeqi NP_001072389.1. NM_001078921.1.
UniGenei Str.5094.

3D structure databases

ProteinModelPortali Q0V9G5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000020288.

Proteomic databases

PaxDbi Q0V9G5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 779843.
KEGGi xtr:779843.

Organism-specific databases

CTDi 84101.
Xenbasei XB-GENE-1014112. usp44.

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000015084.
HOVERGENi HBG018027.
KOi K11834.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
SMARTi SM00290. ZnF_UBP. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: N6.
    Tissue: Oviduct.

Entry informationi

Entry nameiUBP44_XENTR
AccessioniPrimary (citable) accession number: Q0V9G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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