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Q0V9G5

- UBP44_XENTR

UniProt

Q0V9G5 - UBP44_XENTR

Protein

Ubiquitin carboxyl-terminal hydrolase 44

Gene

usp44

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Deubiquitinase that plays a key role in the spindle checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei283 – 2831NucleophilePROSITE-ProRule annotation
    Active sitei639 – 6391Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri24 – 8562UBP-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB
    2. ubiquitin thiolesterase activity Source: UniProtKB
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. anaphase Source: UniProtKB
    2. mitotic nuclear division Source: UniProtKB-KW
    3. negative regulation of mitotic anaphase-promoting complex activity Source: UniProtKB
    4. protein deubiquitination Source: UniProtKB
    5. regulation of spindle checkpoint Source: UniProtKB
    6. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 44 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 44
    Ubiquitin thioesterase 44
    Ubiquitin-specific-processing protease 44
    Gene namesi
    Name:usp44
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-1014112. usp44.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 652652Ubiquitin carboxyl-terminal hydrolase 44PRO_0000395815Add
    BLAST

    Proteomic databases

    PaxDbiQ0V9G5.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000020288.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0V9G5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini274 – 652379USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP44 subfamily.Curated
    Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri24 – 8562UBP-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5533.
    HOGENOMiHOG000015084.
    HOVERGENiHBG018027.
    KOiK11834.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view]
    SMARTiSM00290. ZnF_UBP. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0V9G5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKCKHVGRL RLAQDHSILN PQKWHCVDCN TTESVWACLS CSHVACGRYI    50
    EEHALRHFQD SKHPLALEVN ELYVFCYLCD DYVLNDNTTG DLKLLRSTLS 100
    AIKSQNYDCT TRSGRTLRSM VTADDSFISH EGAQAFLQNE DRAFTALWHR 150
    RHALLGKVFR SWFALTPKGK QRLEEERLRE VAEQKREEAR KRRQQLKRKL 200
    KEEMESTPPR KSSRLKQQMQ PSPKTELPSV QKMNQKYTPT TKQKPPAPTS 250
    IEVCLKKIGN SPIKRKPTVT PGVTGLRNLG NTCYMNSILQ ILSHLHVFRE 300
    CFLQLDLNQT QELLAAAGSG KTRLSSKYPP SAVLPKVTQK HTKVQRSLAR 350
    RQSFSSGLSG GASNSRNMEL IQPKEPSSKH ISLCHELHTL FQVMWSGKWA 400
    LVSPFAMLHS VWRLIPAFRG YAQQDAQEFL CELLDKVQQE LETTGTRYPT 450
    LIPASQRKLI KQVLNIVNNI FHGQLLSQVT CLACDHKSNT IEPFWDLSLE 500
    FPERYHFNGK ETASQRPCLL TEMLAKFTET EALEGKIYAC DQCNTKRRKF 550
    SSKPVVLTEA QKQLMVCRLP QVLRLHLKRF RWSGRNHREK IGVHVRFDQM 600
    LNMEPYCCRE STAALRADCF IYDLSSVVMH HGKGFGSGHY TAFCYNPEGG 650
    NG 652
    Length:652
    Mass (Da):74,676
    Last modified:September 5, 2006 - v1
    Checksum:iA95E03024EA2AF44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC121579 mRNA. Translation: AAI21580.1.
    RefSeqiNP_001072389.1. NM_001078921.1.
    UniGeneiStr.5094.

    Genome annotation databases

    GeneIDi779843.
    KEGGixtr:779843.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC121579 mRNA. Translation: AAI21580.1 .
    RefSeqi NP_001072389.1. NM_001078921.1.
    UniGenei Str.5094.

    3D structure databases

    ProteinModelPortali Q0V9G5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000020288.

    Proteomic databases

    PaxDbi Q0V9G5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 779843.
    KEGGi xtr:779843.

    Organism-specific databases

    CTDi 84101.
    Xenbasei XB-GENE-1014112. usp44.

    Phylogenomic databases

    eggNOGi COG5533.
    HOGENOMi HOG000015084.
    HOVERGENi HBG018027.
    KOi K11834.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view ]
    SMARTi SM00290. ZnF_UBP. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: N6.
      Tissue: Oviduct.

    Entry informationi

    Entry nameiUBP44_XENTR
    AccessioniPrimary (citable) accession number: Q0V9G5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3