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Q0V9G5

- UBP44_XENTR

UniProt

Q0V9G5 - UBP44_XENTR

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Protein

Ubiquitin carboxyl-terminal hydrolase 44

Gene

usp44

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Deubiquitinase that plays a key role in the spindle checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei283 – 2831NucleophilePROSITE-ProRule annotation
Active sitei639 – 6391Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri24 – 8562UBP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB
  2. ubiquitin thiolesterase activity Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. negative regulation of mitotic anaphase-promoting complex activity Source: UniProtKB
  3. protein deubiquitination Source: UniProtKB
  4. regulation of spindle checkpoint Source: UniProtKB
  5. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 44 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 44
Ubiquitin thioesterase 44
Ubiquitin-specific-processing protease 44
Gene namesi
Name:usp44
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1014112. usp44.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 652652Ubiquitin carboxyl-terminal hydrolase 44PRO_0000395815Add
BLAST

Proteomic databases

PaxDbiQ0V9G5.

Expressioni

Gene expression databases

ExpressionAtlasiQ0V9G5. baseline.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000020288.

Structurei

3D structure databases

ProteinModelPortaliQ0V9G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini274 – 652379USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family. USP44 subfamily.Curated
Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri24 – 8562UBP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000015084.
HOVERGENiHBG018027.
InParanoidiQ0V9G5.
KOiK11834.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0V9G5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKCKHVGRL RLAQDHSILN PQKWHCVDCN TTESVWACLS CSHVACGRYI
60 70 80 90 100
EEHALRHFQD SKHPLALEVN ELYVFCYLCD DYVLNDNTTG DLKLLRSTLS
110 120 130 140 150
AIKSQNYDCT TRSGRTLRSM VTADDSFISH EGAQAFLQNE DRAFTALWHR
160 170 180 190 200
RHALLGKVFR SWFALTPKGK QRLEEERLRE VAEQKREEAR KRRQQLKRKL
210 220 230 240 250
KEEMESTPPR KSSRLKQQMQ PSPKTELPSV QKMNQKYTPT TKQKPPAPTS
260 270 280 290 300
IEVCLKKIGN SPIKRKPTVT PGVTGLRNLG NTCYMNSILQ ILSHLHVFRE
310 320 330 340 350
CFLQLDLNQT QELLAAAGSG KTRLSSKYPP SAVLPKVTQK HTKVQRSLAR
360 370 380 390 400
RQSFSSGLSG GASNSRNMEL IQPKEPSSKH ISLCHELHTL FQVMWSGKWA
410 420 430 440 450
LVSPFAMLHS VWRLIPAFRG YAQQDAQEFL CELLDKVQQE LETTGTRYPT
460 470 480 490 500
LIPASQRKLI KQVLNIVNNI FHGQLLSQVT CLACDHKSNT IEPFWDLSLE
510 520 530 540 550
FPERYHFNGK ETASQRPCLL TEMLAKFTET EALEGKIYAC DQCNTKRRKF
560 570 580 590 600
SSKPVVLTEA QKQLMVCRLP QVLRLHLKRF RWSGRNHREK IGVHVRFDQM
610 620 630 640 650
LNMEPYCCRE STAALRADCF IYDLSSVVMH HGKGFGSGHY TAFCYNPEGG

NG
Length:652
Mass (Da):74,676
Last modified:September 5, 2006 - v1
Checksum:iA95E03024EA2AF44
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC121579 mRNA. Translation: AAI21580.1.
RefSeqiNP_001072389.1. NM_001078921.1.
UniGeneiStr.5094.

Genome annotation databases

GeneIDi779843.
KEGGixtr:779843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC121579 mRNA. Translation: AAI21580.1 .
RefSeqi NP_001072389.1. NM_001078921.1.
UniGenei Str.5094.

3D structure databases

ProteinModelPortali Q0V9G5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000020288.

Proteomic databases

PaxDbi Q0V9G5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 779843.
KEGGi xtr:779843.

Organism-specific databases

CTDi 84101.
Xenbasei XB-GENE-1014112. usp44.

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000015084.
HOVERGENi HBG018027.
InParanoidi Q0V9G5.
KOi K11834.

Gene expression databases

ExpressionAtlasi Q0V9G5. baseline.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
SMARTi SM00290. ZnF_UBP. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: N6.
    Tissue: Oviduct.

Entry informationi

Entry nameiUBP44_XENTR
AccessioniPrimary (citable) accession number: Q0V9G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3