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Q0V9G5 (UBP44_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 44
EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 44
Ubiquitin thioesterase 44
Ubiquitin-specific-processing protease 44
Gene names
Name:usp44
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length652 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinase that plays a key role in the spindle checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the peptidase C19 family. USP44 subfamily.

Contains 1 UBP-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 652652Ubiquitin carboxyl-terminal hydrolase 44
PRO_0000395815

Regions

Zinc finger24 – 8562UBP-type

Sites

Active site2831Nucleophile By similarity
Active site6391Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0V9G5 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: A95E03024EA2AF44

FASTA65274,676
        10         20         30         40         50         60 
MDKCKHVGRL RLAQDHSILN PQKWHCVDCN TTESVWACLS CSHVACGRYI EEHALRHFQD 

        70         80         90        100        110        120 
SKHPLALEVN ELYVFCYLCD DYVLNDNTTG DLKLLRSTLS AIKSQNYDCT TRSGRTLRSM 

       130        140        150        160        170        180 
VTADDSFISH EGAQAFLQNE DRAFTALWHR RHALLGKVFR SWFALTPKGK QRLEEERLRE 

       190        200        210        220        230        240 
VAEQKREEAR KRRQQLKRKL KEEMESTPPR KSSRLKQQMQ PSPKTELPSV QKMNQKYTPT 

       250        260        270        280        290        300 
TKQKPPAPTS IEVCLKKIGN SPIKRKPTVT PGVTGLRNLG NTCYMNSILQ ILSHLHVFRE 

       310        320        330        340        350        360 
CFLQLDLNQT QELLAAAGSG KTRLSSKYPP SAVLPKVTQK HTKVQRSLAR RQSFSSGLSG 

       370        380        390        400        410        420 
GASNSRNMEL IQPKEPSSKH ISLCHELHTL FQVMWSGKWA LVSPFAMLHS VWRLIPAFRG 

       430        440        450        460        470        480 
YAQQDAQEFL CELLDKVQQE LETTGTRYPT LIPASQRKLI KQVLNIVNNI FHGQLLSQVT 

       490        500        510        520        530        540 
CLACDHKSNT IEPFWDLSLE FPERYHFNGK ETASQRPCLL TEMLAKFTET EALEGKIYAC 

       550        560        570        580        590        600 
DQCNTKRRKF SSKPVVLTEA QKQLMVCRLP QVLRLHLKRF RWSGRNHREK IGVHVRFDQM 

       610        620        630        640        650 
LNMEPYCCRE STAALRADCF IYDLSSVVMH HGKGFGSGHY TAFCYNPEGG NG

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: N6.
Tissue: Oviduct.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC121579 mRNA. Translation: AAI21580.1.
RefSeqNP_001072389.1. NM_001078921.1.
UniGeneStr.5094.

3D structure databases

ProteinModelPortalQ0V9G5.
ModBaseSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000020288.

Proteomic databases

PaxDbQ0V9G5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID779843.
KEGGxtr:779843.

Organism-specific databases

CTD84101.
XenbaseXB-GENE-1014112. usp44.

Phylogenomic databases

eggNOGCOG5533.
HOGENOMHOG000015084.
HOVERGENHBG018027.
KOK11834.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
SMARTSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEPS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. 1 hit.
PS50235. UCH_2_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP44_XENTR
AccessionPrimary (citable) accession number: Q0V9G5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 5, 2006
Last modified: April 3, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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