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Q0V9E9

- SETD8_XENTR

UniProt

Q0V9E9 - SETD8_XENTR

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Protein

N-lysine methyltransferase SETD8

Gene

setd8

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei255 – 2551S-adenosyl-L-methioninePROSITE-ProRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB

GO - Biological processi

  1. histone lysine methylation Source: GOC
  2. mitotic nuclear division Source: UniProtKB-KW
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
N-lysine methyltransferase SETD8 (EC:2.1.1.-)
Alternative name(s):
Histone-lysine N-methyltransferase SETD8 (EC:2.1.1.43)
SET domain-containing protein 8
Gene namesi
Name:setd8
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-489177. setd8.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity
Note: Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms (By similarity).By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336N-lysine methyltransferase SETD8PRO_0000317002Add
BLAST

Expressioni

Gene expression databases

BgeeiQ0V9E9.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000012803.

Structurei

3D structure databases

ProteinModelPortaliQ0V9E9.
SMRiQ0V9E9. Positions 176-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini200 – 321122SETPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni210 – 2123S-adenosyl-L-methionine bindingPROSITE-ProRule annotation
Regioni282 – 2832S-adenosyl-L-methionine bindingPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2940.
GeneTreeiENSGT00410000025501.
HOGENOMiHOG000020818.
HOVERGENiHBG067546.
InParanoidiQ0V9E9.
KOiK11428.
OMAiGAKENEP.
OrthoDBiEOG70KGRN.
TreeFamiTF335181.

Family and domain databases

InterProiIPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0V9E9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRGKKMSKP GDGRSGDVPD TGRTGGTNEN HPKINGEVAH LGQPKIYSFM
60 70 80 90 100
SPTKSPSARP PLQEENSVAH HESKCPGKPL TETRKKAEVE KKRISSGTEL
110 120 130 140 150
SVKPSEQRET ECNSIGEFLD PKQEQTDVRR NIALPPADKL NHQKMVKDKP
160 170 180 190 200
LRRKAQRKKS PNRKLTDYYP VRRSCRKSKT ELESEEKKRI DELIQTGKEE
210 220 230 240 250
GMKMDMITGK GRGVIATRDF QRGEFVVEYH GDLIEITDAK RREATYAQDS
260 270 280 290 300
NTGCYMYYFQ YLNKTYCIDA TRETGRLGRL INHSKSGNCH TKLHNINNVP
310 320 330
HLILVASRDI NVGEELLYDY GDRRKSSLEA HPWLKN
Length:336
Mass (Da):38,237
Last modified:September 5, 2006 - v1
Checksum:i422D7B38C168DCA1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC121601 mRNA. Translation: AAI21602.1.
RefSeqiNP_001072815.1. NM_001079347.1.
UniGeneiStr.11037.

Genome annotation databases

EnsembliENSXETT00000012803; ENSXETP00000012803; ENSXETG00000005820.
GeneIDi780276.
KEGGixtr:780276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC121601 mRNA. Translation: AAI21602.1 .
RefSeqi NP_001072815.1. NM_001079347.1.
UniGenei Str.11037.

3D structure databases

ProteinModelPortali Q0V9E9.
SMRi Q0V9E9. Positions 176-336.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000012803.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000012803 ; ENSXETP00000012803 ; ENSXETG00000005820 .
GeneIDi 780276.
KEGGi xtr:780276.

Organism-specific databases

CTDi 387893.
Xenbasei XB-GENE-489177. setd8.

Phylogenomic databases

eggNOGi COG2940.
GeneTreei ENSGT00410000025501.
HOGENOMi HOG000020818.
HOVERGENi HBG067546.
InParanoidi Q0V9E9.
KOi K11428.
OMAi GAKENEP.
OrthoDBi EOG70KGRN.
TreeFami TF335181.

Gene expression databases

Bgeei Q0V9E9.

Family and domain databases

InterProi IPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
PIRSFi PIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
SMARTi SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: N6.
    Tissue: Ovary.

Entry informationi

Entry nameiSETD8_XENTR
AccessioniPrimary (citable) accession number: Q0V9E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3