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Protein

Contactin-associated protein like 5-3

Gene

Cntnap5c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-associated protein like 5-3
Alternative name(s):
Cell recognition molecule Caspr5-3
Cell recognition molecule Caspr5c
Contactin-associated protein-like 5c
Gene namesi
Name:Cntnap5c
Synonyms:Caspr5-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3646013 Cntnap5c

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 1235ExtracellularSequence analysisAdd BLAST1211
Transmembranei1236 – 1256HelicalSequence analysisAdd BLAST21
Topological domaini1257 – 1305CytoplasmicSequence analysisAdd BLAST49

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000031738025 – 1305Contactin-associated protein like 5-3Add BLAST1281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi329 ↔ 360By similarity
Glycosylationi496N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi512 ↔ 544By similarity
Disulfide bondi550 ↔ 561By similarity
Disulfide bondi555 ↔ 570By similarity
Glycosylationi571N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi572 ↔ 582By similarity
Disulfide bondi929 ↔ 956By similarity
Disulfide bondi960 ↔ 973By similarity
Disulfide bondi967 ↔ 982By similarity
Disulfide bondi984 ↔ 994By similarity
Glycosylationi1023N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1057N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1163 ↔ 1198By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ0V8T7
PaxDbiQ0V8T7
PRIDEiQ0V8T7

PTM databases

iPTMnetiQ0V8T7
PhosphoSitePlusiQ0V8T7

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Developmental stagei

Expressed from E6 in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000038048
CleanExiMM_CNTNAP5C

Structurei

3D structure databases

ProteinModelPortaliQ0V8T7
SMRiQ0V8T7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 174F5/8 type CPROSITE-ProRule annotationAdd BLAST150
Domaini180 – 360Laminin G-like 1PROSITE-ProRule annotationAdd BLAST181
Domaini367 – 544Laminin G-like 2PROSITE-ProRule annotationAdd BLAST178
Domaini546 – 583EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini584 – 790Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST207
Domaini791 – 956Laminin G-like 3PROSITE-ProRule annotationAdd BLAST166
Domaini957 – 995EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Domaini1013 – 1198Laminin G-like 4PROSITE-ProRule annotationAdd BLAST186

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi44 – 47Poly-Ser4

Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3516 Eukaryota
ENOG410XPHG LUCA
GeneTreeiENSGT00760000118991
HOGENOMiHOG000230964
HOVERGENiHBG057718
InParanoidiQ0V8T7
OMAiINSHRRM
OrthoDBiEOG091G00LF
PhylomeDBiQ0V8T7
TreeFamiTF321823

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR028874 Caspr5
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000421 FA58C
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR008979 Galactose-bd-like_sf
IPR001791 Laminin_G
PANTHERiPTHR43925:SF4 PTHR43925:SF4, 1 hit
PfamiView protein in Pfam
PF00754 F5_F8_type_C, 1 hit
PF02210 Laminin_G_2, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00231 FA58C, 1 hit
SM00282 LamG, 4 hits
SUPFAMiSSF49785 SSF49785, 1 hit
SSF49899 SSF49899, 4 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS50026 EGF_3, 2 hits
PS01286 FA58C_2, 1 hit
PS50022 FA58C_3, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50025 LAM_G_DOMAIN, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0V8T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVPRLNSV FTLVLSGLWH FGLTATNYNC DDPLTSFLSL RAFSSSSDLT
60 70 80 90 100
GRSSPAQLNW RMGTGGWSPA DSNAQQWLQM DLGNRVEITA VATQGRYGSS
110 120 130 140 150
DWVTSYRLMF SDTGHNWQQY TQEGSIWRFV GNMNANSVVH HKLLNSVRAR
160 170 180 190 200
FVRFVPLEWN PNGKIGMRVE VYGCSYRSDV ADFDGWSSLL YRFNQKTMST
210 220 230 240 250
LKDVISLKFK SIQRDGVLFH GEGQRGDHIT LELQNGRLAL YLNLDDSKAQ
260 270 280 290 300
VSSTAPLATL GSLLDDQHWH SVLLERVGKQ ANFTVDKNTQ HFQTKGETDA
310 320 330 340 350
LDIDYELSFG GIPVPSKPGT FLKKNFHGCI ENLYYNGVNI IDLAKRRKHQ
360 370 380 390 400
IYSGNVTFSC SEPQTVPITF VNSRSSYLLL TGTPQIDGLS VSFQFRTWNE
410 420 430 440 450
DGLLLSTELS EGSGTLLLIL EGGTLRLLIK KLARHGTEIF TGSGLNDGMW
460 470 480 490 500
HSVSISARRN RVTLTLDNDA ASLPPDTSWL QIYSGNSYYF GGCPDNLTDS
510 520 530 540 550
QCLNPIKAFQ GCMRLIFIDN QPKDLISVQQ GSLGSFSDLH IDLCSIKDRC
560 570 580 590 600
LPNYCEHGGQ CAQTWTNFYC NCSDTGYTGA TCHDSIYEQS CEVYRHRGKT
610 620 630 640 650
AEFFYVDSDG SGPLGPLQVF CNITEDKIWM TVQHNNTGLT WVQGSNPEKP
660 670 680 690 700
YAMTLNYGGS LEQLEALIDG SEHCEQEVTY YCKRSRLLNT PDGVPFTWWI
710 720 730 740 750
GRSNEKHPYW GGSLPGVQQC GCGLEESCLD IRHFCNCDAD TDEWTNDTGY
760 770 780 790 800
LSFKDHLPVT QIIITDTNRS KSEAAWRIGP LRCYGDRHFW NAVSFSTEAS
810 820 830 840 850
FLHFPTFRVE FSADIFFFFK TTALSGVFLE ILGIKDFLRL EMSSPSEVIF
860 870 880 890 900
AIDVGNGPID LLVQSPYPLN DNQWHYIRAE RNLKETSLQV DNLPQSMREA
910 920 930 940 950
SEEGHFQFQL NSQLFVGGKS SRQKGFFGCI RSLHLNGQNI DLEERAKVTS
960 970 980 990 1000
GVRPGCPGHC SSYGRNCQNG GKCVEKHIGY SCDCTNSPYE GPFCQKEISA
1010 1020 1030 1040 1050
LFDSDTSVTY MFQEPYSVTK NTNLSSSAIY TDTAPSKEII MLSFMTAQAP
1060 1070 1080 1090 1100
TLLLYLNFSS QNFLAILLSW NGSLQIHYQL SKEESHVFTI NTENLANRRV
1110 1120 1130 1140 1150
HQVKMSRDGP ELSIQMDQQL FSYTFSLESE FQRARSLVLG KVTETLGLDP
1160 1170 1180 1190 1200
EVARANTLGF VGCLSSVQYN HITPLKAALR HASISPVTVQ RTLTESSCVS
1210 1220 1230 1240 1250
MVDSDANAVT TVYSSTDPFG ERDEREPLTN AVPSDLAVIG GIIAVVTFIS
1260 1270 1280 1290 1300
FSVIGIMTHF FYQHKRSHYA SQMKEKEYPE NVDSSSRNDI DLQNTTRECK

QEDFI
Length:1,305
Mass (Da):146,242
Last modified:September 5, 2006 - v1
Checksum:i623EB2D81A4D9953
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118684 Genomic DNA No translation available.
AC120548 Genomic DNA No translation available.
AC122209 Genomic DNA No translation available.
AC127557 Genomic DNA No translation available.
AC154498 Genomic DNA No translation available.
CT025622 Genomic DNA No translation available.
CT025736 Genomic DNA No translation available.
BN000867 mRNA Translation: CAJ55747.1
CCDSiCCDS37671.1
RefSeqiNP_001075122.1, NM_001081653.1
UniGeneiMm.391030

Genome annotation databases

EnsembliENSMUST00000076038; ENSMUSP00000075416; ENSMUSG00000038048
GeneIDi620292
KEGGimmu:620292
UCSCiuc008dew.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCTP5C_MOUSE
AccessioniPrimary (citable) accession number: Q0V8T7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health