Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Contactin-associated protein like 5-3

Gene

Cntnap5c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-associated protein like 5-3
Alternative name(s):
Cell recognition molecule Caspr5-3
Cell recognition molecule Caspr5c
Contactin-associated protein-like 5c
Gene namesi
Name:Cntnap5c
Synonyms:Caspr5-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3646013. Cntnap5c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 12351211ExtracellularSequence analysisAdd
BLAST
Transmembranei1236 – 125621HelicalSequence analysisAdd
BLAST
Topological domaini1257 – 130549CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 13051281Contactin-associated protein like 5-3PRO_0000317380Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence analysis
Disulfide bondi329 ↔ 360By similarity
Glycosylationi496 – 4961N-linked (GlcNAc...)Sequence analysis
Disulfide bondi512 ↔ 544By similarity
Disulfide bondi550 ↔ 561By similarity
Disulfide bondi555 ↔ 570By similarity
Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence analysis
Disulfide bondi572 ↔ 582By similarity
Disulfide bondi929 ↔ 956By similarity
Disulfide bondi960 ↔ 973By similarity
Disulfide bondi967 ↔ 982By similarity
Disulfide bondi984 ↔ 994By similarity
Glycosylationi1023 – 10231N-linked (GlcNAc...)Sequence analysis
Glycosylationi1057 – 10571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1163 ↔ 1198By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ0V8T7.
PaxDbiQ0V8T7.
PRIDEiQ0V8T7.

PTM databases

iPTMnetiQ0V8T7.
PhosphoSiteiQ0V8T7.

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Developmental stagei

Expressed from E6 in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000038048.
CleanExiMM_CNTNAP5C.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075416.

Structurei

3D structure databases

ProteinModelPortaliQ0V8T7.
SMRiQ0V8T7. Positions 27-174, 180-582, 791-1178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 174150F5/8 type CPROSITE-ProRule annotationAdd
BLAST
Domaini180 – 360181Laminin G-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini367 – 544178Laminin G-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini546 – 58338EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini584 – 790207Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini791 – 956166Laminin G-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini957 – 99539EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini1013 – 1198186Laminin G-like 4PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 474Poly-Ser

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation
Contains 4 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3516. Eukaryota.
ENOG410XPHG. LUCA.
GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230964.
HOVERGENiHBG057718.
InParanoidiQ0V8T7.
OMAiDFLRLEM.
OrthoDBiEOG091G00LF.
PhylomeDBiQ0V8T7.
TreeFamiTF321823.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
InterProiIPR028874. Caspr5.
IPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000421. FA58C.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
[Graphical view]
PANTHERiPTHR10127:SF611. PTHR10127:SF611. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 4 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0V8T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVPRLNSV FTLVLSGLWH FGLTATNYNC DDPLTSFLSL RAFSSSSDLT
60 70 80 90 100
GRSSPAQLNW RMGTGGWSPA DSNAQQWLQM DLGNRVEITA VATQGRYGSS
110 120 130 140 150
DWVTSYRLMF SDTGHNWQQY TQEGSIWRFV GNMNANSVVH HKLLNSVRAR
160 170 180 190 200
FVRFVPLEWN PNGKIGMRVE VYGCSYRSDV ADFDGWSSLL YRFNQKTMST
210 220 230 240 250
LKDVISLKFK SIQRDGVLFH GEGQRGDHIT LELQNGRLAL YLNLDDSKAQ
260 270 280 290 300
VSSTAPLATL GSLLDDQHWH SVLLERVGKQ ANFTVDKNTQ HFQTKGETDA
310 320 330 340 350
LDIDYELSFG GIPVPSKPGT FLKKNFHGCI ENLYYNGVNI IDLAKRRKHQ
360 370 380 390 400
IYSGNVTFSC SEPQTVPITF VNSRSSYLLL TGTPQIDGLS VSFQFRTWNE
410 420 430 440 450
DGLLLSTELS EGSGTLLLIL EGGTLRLLIK KLARHGTEIF TGSGLNDGMW
460 470 480 490 500
HSVSISARRN RVTLTLDNDA ASLPPDTSWL QIYSGNSYYF GGCPDNLTDS
510 520 530 540 550
QCLNPIKAFQ GCMRLIFIDN QPKDLISVQQ GSLGSFSDLH IDLCSIKDRC
560 570 580 590 600
LPNYCEHGGQ CAQTWTNFYC NCSDTGYTGA TCHDSIYEQS CEVYRHRGKT
610 620 630 640 650
AEFFYVDSDG SGPLGPLQVF CNITEDKIWM TVQHNNTGLT WVQGSNPEKP
660 670 680 690 700
YAMTLNYGGS LEQLEALIDG SEHCEQEVTY YCKRSRLLNT PDGVPFTWWI
710 720 730 740 750
GRSNEKHPYW GGSLPGVQQC GCGLEESCLD IRHFCNCDAD TDEWTNDTGY
760 770 780 790 800
LSFKDHLPVT QIIITDTNRS KSEAAWRIGP LRCYGDRHFW NAVSFSTEAS
810 820 830 840 850
FLHFPTFRVE FSADIFFFFK TTALSGVFLE ILGIKDFLRL EMSSPSEVIF
860 870 880 890 900
AIDVGNGPID LLVQSPYPLN DNQWHYIRAE RNLKETSLQV DNLPQSMREA
910 920 930 940 950
SEEGHFQFQL NSQLFVGGKS SRQKGFFGCI RSLHLNGQNI DLEERAKVTS
960 970 980 990 1000
GVRPGCPGHC SSYGRNCQNG GKCVEKHIGY SCDCTNSPYE GPFCQKEISA
1010 1020 1030 1040 1050
LFDSDTSVTY MFQEPYSVTK NTNLSSSAIY TDTAPSKEII MLSFMTAQAP
1060 1070 1080 1090 1100
TLLLYLNFSS QNFLAILLSW NGSLQIHYQL SKEESHVFTI NTENLANRRV
1110 1120 1130 1140 1150
HQVKMSRDGP ELSIQMDQQL FSYTFSLESE FQRARSLVLG KVTETLGLDP
1160 1170 1180 1190 1200
EVARANTLGF VGCLSSVQYN HITPLKAALR HASISPVTVQ RTLTESSCVS
1210 1220 1230 1240 1250
MVDSDANAVT TVYSSTDPFG ERDEREPLTN AVPSDLAVIG GIIAVVTFIS
1260 1270 1280 1290 1300
FSVIGIMTHF FYQHKRSHYA SQMKEKEYPE NVDSSSRNDI DLQNTTRECK

QEDFI
Length:1,305
Mass (Da):146,242
Last modified:September 5, 2006 - v1
Checksum:i623EB2D81A4D9953
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118684 Genomic DNA. No translation available.
AC120548 Genomic DNA. No translation available.
AC122209 Genomic DNA. No translation available.
AC127557 Genomic DNA. No translation available.
AC154498 Genomic DNA. No translation available.
CT025622 Genomic DNA. No translation available.
CT025736 Genomic DNA. No translation available.
BN000867 mRNA. Translation: CAJ55747.1.
CCDSiCCDS37671.1.
RefSeqiNP_001075122.1. NM_001081653.1.
UniGeneiMm.391030.

Genome annotation databases

EnsembliENSMUST00000076038; ENSMUSP00000075416; ENSMUSG00000038048.
GeneIDi620292.
KEGGimmu:620292.
UCSCiuc008dew.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118684 Genomic DNA. No translation available.
AC120548 Genomic DNA. No translation available.
AC122209 Genomic DNA. No translation available.
AC127557 Genomic DNA. No translation available.
AC154498 Genomic DNA. No translation available.
CT025622 Genomic DNA. No translation available.
CT025736 Genomic DNA. No translation available.
BN000867 mRNA. Translation: CAJ55747.1.
CCDSiCCDS37671.1.
RefSeqiNP_001075122.1. NM_001081653.1.
UniGeneiMm.391030.

3D structure databases

ProteinModelPortaliQ0V8T7.
SMRiQ0V8T7. Positions 27-174, 180-582, 791-1178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075416.

PTM databases

iPTMnetiQ0V8T7.
PhosphoSiteiQ0V8T7.

Proteomic databases

MaxQBiQ0V8T7.
PaxDbiQ0V8T7.
PRIDEiQ0V8T7.

Protocols and materials databases

DNASUi620292.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076038; ENSMUSP00000075416; ENSMUSG00000038048.
GeneIDi620292.
KEGGimmu:620292.
UCSCiuc008dew.1. mouse.

Organism-specific databases

CTDi620292.
MGIiMGI:3646013. Cntnap5c.

Phylogenomic databases

eggNOGiKOG3516. Eukaryota.
ENOG410XPHG. LUCA.
GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230964.
HOVERGENiHBG057718.
InParanoidiQ0V8T7.
OMAiDFLRLEM.
OrthoDBiEOG091G00LF.
PhylomeDBiQ0V8T7.
TreeFamiTF321823.

Miscellaneous databases

PROiQ0V8T7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038048.
CleanExiMM_CNTNAP5C.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
InterProiIPR028874. Caspr5.
IPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000421. FA58C.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
[Graphical view]
PANTHERiPTHR10127:SF611. PTHR10127:SF611. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 4 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTP5C_MOUSE
AccessioniPrimary (citable) accession number: Q0V8T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.