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Protein

Contactin-associated protein like 5-3

Gene

Cntnap5c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-associated protein like 5-3
Alternative name(s):
Cell recognition molecule Caspr5-3
Cell recognition molecule Caspr5c
Contactin-associated protein-like 5c
Gene namesi
Name:Cntnap5c
Synonyms:Caspr5-3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 12381214ExtracellularSequence analysisAdd
BLAST
Transmembranei1239 – 125921HelicalSequence analysisAdd
BLAST
Topological domaini1260 – 130748CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 13071283Contactin-associated protein like 5-3PRO_0000317383Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 175By similarity
Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence analysis
Disulfide bondi330 ↔ 361By similarity
Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence analysis
Disulfide bondi513 ↔ 545By similarity
Disulfide bondi551 ↔ 562By similarity
Disulfide bondi556 ↔ 571By similarity
Disulfide bondi573 ↔ 583By similarity
Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence analysis
Glycosylationi624 – 6241N-linked (GlcNAc...)Sequence analysis
Glycosylationi637 – 6371N-linked (GlcNAc...)Sequence analysis
Disulfide bondi931 ↔ 958By similarity
Disulfide bondi962 ↔ 975By similarity
Disulfide bondi969 ↔ 984By similarity
Disulfide bondi986 ↔ 996By similarity
Disulfide bondi1165 ↔ 1200By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ0V8T4.
PRIDEiQ0V8T4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040012.

Structurei

3D structure databases

ProteinModelPortaliQ0V8T4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 175145F5/8 type CPROSITE-ProRule annotationAdd
BLAST
Domaini181 – 361181Laminin G-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini368 – 545178Laminin G-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini547 – 58438EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini585 – 792208Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini793 – 958166Laminin G-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini959 – 99739EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini1019 – 1200182Laminin G-like 4PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi45 – 484Poly-Ser

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation
Contains 4 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3516. Eukaryota.
ENOG410XPHG. LUCA.
HOGENOMiHOG000230964.
HOVERGENiHBG057718.
InParanoidiQ0V8T4.
PhylomeDBiQ0V8T4.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
InterProiIPR028874. Caspr5.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR000742. EGF-like_dom.
IPR000421. FA58C.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
[Graphical view]
PANTHERiPTHR10127:SF611. PTHR10127:SF611. 1 hit.
PfamiPF00008. EGF. 1 hit.
PF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 4 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0V8T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFVPRLNSV LTLVLSGLWH FGLTATNCDN CDDPLASFLS LRAFSSSSDV
60 70 80 90 100
TGSSSPAHLN WRMGTGGWSP AYSNAQQWLQ IDLGNRVEIT AVATQGRYGS
110 120 130 140 150
SDWVTSYRLM FSDTGHNWQE YKQEDNIWTF VGNMNADSVV HHKLLHSVRA
160 170 180 190 200
RFVRFVPLKW NPDGKIGMRM EVYGCSYRSD VADFDGHSSL LYRFNQKTMS
210 220 230 240 250
TLKDMISLKF KSMQGDGVLL HGEGQRGDYI TLELQNGRLA LYLNLDGGQA
260 270 280 290 300
RLSSIAPSAI LGSLLDDQQW HSVLLERVGK QTNFTVDTNT EHFQIKAETD
310 320 330 340 350
ALDIDYELSF GGIPIPSKPG TFLKKSFHGC IENLYYNGVN IIDLAKRRKH
360 370 380 390 400
QIYSGNVTFS CSEPQIVPIT FVNSRSSYLL LPGTPRIDGL SVSFQFRTWN
410 420 430 440 450
EDGLLLSTEL SESSGTLLLI LEGGTLRLLI KKVAGHGTEI ITGSGLNDGL
460 470 480 490 500
WHFVSINARR NRVTLTLDND AASLPPDISW LQIYSGNSYY FGGCPDNLTD
510 520 530 540 550
SQCLNPIKAF QGCMRLIFID NQPKDLISVQ QGSLGNFSDL HIDLCSIKDR
560 570 580 590 600
CLPNYCEHGG HCVQTWTTFY CNCSNTGYTG ATCHDSIYEQ SCEVYRHRGN
610 620 630 640 650
NTSGFFFVDS DGSGPLEPLQ LYCNITEDKI WMTIQHNITE LTQVQGSNAE
660 670 680 690 700
KPYSMTLNYG GSMDQLVALI DGSEYCEQEV TYHCRRSRLL NTPDGAPFTW
710 720 730 740 750
WIGRSNEKHH YWGGSVPGIQ KCGCGLEQSC LDIGHFCNCD ADTDEWANDT
760 770 780 790 800
GFLSFKDHLP VTQIIITDTN RSNSEAAWRI GPLRCYGDRH FWNAVSFSTE
810 820 830 840 850
ASYLHFPTSH VEFSIDISFF FKTTALSGVF IENLGIKDFL RLELSSPSEV
860 870 880 890 900
TFAIDVGNGP TELLVQSPSP LNDNQWHYIQ AERNLKETSL QVDNFPRIMR
910 920 930 940 950
ETTEKGHFQL QLNSQMFVGG TSSRQKGFLG CIRSLHLNGQ NIDLEERGMV
960 970 980 990 1000
TSGVRPGCPG HCSSYGNNCH NGGKCVEKHN SYSCDCTKSP YEGPFCQKEI
1010 1020 1030 1040 1050
SALFDSTTSI TYMFQEPYPV SKNTSTSSSA IYTDTVLSKE TILLSFVTAQ
1060 1070 1080 1090 1100
APTLLLYLNF STPSFLALLL SRNGSLQILY HLSKGESHMF TVSTENLANR
1110 1120 1130 1140 1150
RVHHVKMNRD GTELSIQMDQ QLFSYNFPLE AEFLTVRSLI LGKVTETLGL
1160 1170 1180 1190 1200
DPRVARANSL GFIGCLSSVQ YNHIAPLKAA LRHASIAPAT VQGSLREFSC
1210 1220 1230 1240 1250
GSMVDSDVNA VTTVYSSSDP FGKTDDHDPL TNAVLSDSAV IGGVIAVVTF
1260 1270 1280 1290 1300
ITFCVIGIMT RFLYQHKQSH CTSQKKEKEY SENLDSSFRH DIDLQSTTSK

CKREYFI
Length:1,307
Mass (Da):145,719
Last modified:October 31, 2006 - v1
Checksum:iBA9E0BED62A92660
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03084915 Genomic DNA. No translation available.
AABR03084985 Genomic DNA. No translation available.
AABR03085159 Genomic DNA. No translation available.
AABR03085253 Genomic DNA. No translation available.
AABR03085581 Genomic DNA. No translation available.
AABR03085657 Genomic DNA. No translation available.
AABR03085682 Genomic DNA. No translation available.
AABR03085702 Genomic DNA. No translation available.
AABR03086240 Genomic DNA. No translation available.
AABR03086399 Genomic DNA. No translation available.
AABR03086675 Genomic DNA. No translation available.
AABR03086698 Genomic DNA. No translation available.
AABR03086915 Genomic DNA. No translation available.
AABR03087310 Genomic DNA. No translation available.
BN000870 mRNA. Translation: CAJ55732.1.
RefSeqiNP_001041338.1. NM_001047873.1.
UniGeneiRn.202933.

Genome annotation databases

GeneIDi301650.
KEGGirno:301650.
UCSCiRGD:1565194. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03084915 Genomic DNA. No translation available.
AABR03084985 Genomic DNA. No translation available.
AABR03085159 Genomic DNA. No translation available.
AABR03085253 Genomic DNA. No translation available.
AABR03085581 Genomic DNA. No translation available.
AABR03085657 Genomic DNA. No translation available.
AABR03085682 Genomic DNA. No translation available.
AABR03085702 Genomic DNA. No translation available.
AABR03086240 Genomic DNA. No translation available.
AABR03086399 Genomic DNA. No translation available.
AABR03086675 Genomic DNA. No translation available.
AABR03086698 Genomic DNA. No translation available.
AABR03086915 Genomic DNA. No translation available.
AABR03087310 Genomic DNA. No translation available.
BN000870 mRNA. Translation: CAJ55732.1.
RefSeqiNP_001041338.1. NM_001047873.1.
UniGeneiRn.202933.

3D structure databases

ProteinModelPortaliQ0V8T4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040012.

Proteomic databases

PaxDbiQ0V8T4.
PRIDEiQ0V8T4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi301650.
KEGGirno:301650.
UCSCiRGD:1565194. rat.

Organism-specific databases

CTDi241175.

Phylogenomic databases

eggNOGiKOG3516. Eukaryota.
ENOG410XPHG. LUCA.
HOGENOMiHOG000230964.
HOVERGENiHBG057718.
InParanoidiQ0V8T4.
PhylomeDBiQ0V8T4.

Miscellaneous databases

PROiQ0V8T4.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
InterProiIPR028874. Caspr5.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR000742. EGF-like_dom.
IPR000421. FA58C.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
[Graphical view]
PANTHERiPTHR10127:SF611. PTHR10127:SF611. 1 hit.
PfamiPF00008. EGF. 1 hit.
PF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 4 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "New members of the neurexin superfamily: multiple rodent homologues of the human CASPR5 gene."
    Traut W., Weichenhan D., Himmelbauer H., Winking H.
    Mamm. Genome 17:723-731(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiCTP5C_RAT
AccessioniPrimary (citable) accession number: Q0V8T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 31, 2006
Last modified: June 8, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.