Q0V8R6 (HEXA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-hexosaminidase subunit alpha
EC=3.2.1.52

Alternative name(s):
Beta-N-acetylhexosaminidase subunit alpha
Short name=Hexosaminidase subunit A
N-acetyl-beta-glucosaminidase subunit alpha

Gene names

Name:

HEXA

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues By similarity.
Catalytic activity	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
Subcellular location	Lysosome By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 20 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: EC cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	By similarity
	Propeptide	23 – 88	66	By similarity		PRO_0000274203
	Chain	89 – 529	441	Beta-hexosaminidase subunit alpha		PRO_0000274204
Sites
	Active site	323	1	Proton donor By similarity
Amino acid modifications
	Glycosylation	115	1	N-linked (GlcNAc...) Potential
	Glycosylation	157	1	N-linked (GlcNAc...) Potential
	Glycosylation	295	1	N-linked (GlcNAc...) Potential
	Disulfide bond	58 ↔ 104		By similarity
	Disulfide bond	277 ↔ 328		By similarity
	Disulfide bond	505 ↔ 522		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0V8R6 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 878641B502FCD3A9	FASTA	529	60,353
	10 20 30 40 50 60 MAGSTLRFSL LLAAAFAGRA TALWPWPQYI QTSELRYTIF PQSFQFQYHL SSAAQVGCSV 70 80 90 100 110 120 LDEAFQRYRD LLFGSVAFRF PHPIEKRHTS EKNSLVVLVV TPGCDQFPSL GSVENYTLTI 130 140 150 160 170 180 NDEQSLLLSE TVWGALRGLE TFSQLIWRSP EGTFYVNKTD IEDFPRFPHR GLLLDTSRHY 190 200 210 220 230 240 LPLASILDTL DVMAYNKFNV FHWHLVDDSS FPYESFTFPE LTKKGSYNPA THIYTAQDVK 250 260 270 280 290 300 EVIEYARLRG IRVLAEFDTP GHTLSWGPGV PGLLTPCYSG SHPSGTFGPV NPALNNTYEF 310 320 330 340 350 360 MSTFFLEIST VFPDFYLHLG GDEVDFTCWK SNPDIQAFMK KKGFGDDFKK LESFYIQTLL 370 380 390 400 410 420 DIVSAYGKGY VVWQEVFDNK VKVRPDTIIQ VWREEIPVKY VKELALVTRA GFRALLSAPW 430 440 450 460 470 480 YLNHITYGPD WKEIYLVEPL AFEGSPEQKA LVIGGEACMW GEYVDSTNLV PRLWPRAGAV 490 500 510 520 AERLWSNKMV SNLDFAFKRL AHFRCELLRR GVQAQPLSVG YCDMEFEQT

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BT026152 mRNA. Translation: ABG66991.1.
IPI	IPI00702413.
RefSeq	NP_001068632.1. NM_001075164.1.
UniGene	Bt.6065.
3D structure databases
ProteinModelPortal	Q0V8R6.
SMR	Q0V8R6. Positions 23-528.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0V8R6.
Protein family/group databases
CAZy	GH20. Glycoside Hydrolase Family 20.
Proteomic databases
PRIDE	Q0V8R6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000017261; ENSBTAP00000017261; ENSBTAG00000012981.
GeneID	504468.
KEGG	bta:504468.
Organism-specific databases
CTD	3073.
Phylogenomic databases
eggNOG	maNOG13966.
GeneTree	ENSGT00390000008107.
HOVERGEN	HBG005961.
InParanoid	Q0V8R6.
OMA	DIVDFPR.
OrthoDB	EOG42Z4Q7.
Family and domain databases
InterPro	IPR015882. Acetylhexosaminidase_sua/b. IPR001540. Glyco_hydro_20. IPR015883. Glyco_hydro_20_cat-core. IPR013781. Glyco_hydro_subgr_catalytic. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
KO	K12373.
Pfam	PF00728. Glyco_hydro_20. 1 hit. PF02838. Glyco_hydro_20b. 1 hit. [Graphical view]
PRINTS	PR00738. GLHYDRLASE20.
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HEXA_BOVIN

Accession

Primary (citable) accession number: Q0V8R6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	September 5, 2006
Last modified:	November 16, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program