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Q0V8R6

- HEXA_BOVIN

UniProt

Q0V8R6 - HEXA_BOVIN

Protein

Beta-hexosaminidase subunit alpha

Gene

HEXA

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.By similarity

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei323 – 3231Proton donorBy similarity

    GO - Molecular functioni

    1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. adult walking behavior Source: Ensembl
    2. carbohydrate metabolic process Source: InterPro
    3. cell morphogenesis involved in neuron differentiation Source: Ensembl
    4. ganglioside catabolic process Source: Ensembl
    5. glycosaminoglycan metabolic process Source: Ensembl
    6. lipid storage Source: Ensembl
    7. lysosome organization Source: Ensembl
    8. myelination Source: Ensembl
    9. neuromuscular process controlling balance Source: Ensembl
    10. neuromuscular process controlling posture Source: Ensembl
    11. sensory perception of sound Source: Ensembl
    12. sexual reproduction Source: Ensembl
    13. skeletal system development Source: Ensembl

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_204575. Glycosphingolipid metabolism.
    REACT_217191. CS/DS degradation.
    REACT_217291. Keratan sulfate degradation.
    REACT_224746. Hyaluronan uptake and degradation.

    Protein family/group databases

    CAZyiGH20. Glycoside Hydrolase Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-hexosaminidase subunit alpha (EC:3.2.1.52)
    Alternative name(s):
    Beta-N-acetylhexosaminidase subunit alpha
    Short name:
    Hexosaminidase subunit A
    N-acetyl-beta-glucosaminidase subunit alpha
    Gene namesi
    Name:HEXA
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 10

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell
    2. membrane Source: Ensembl

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Propeptidei23 – 8866By similarityPRO_0000274203Add
    BLAST
    Chaini89 – 529441Beta-hexosaminidase subunit alphaPRO_0000274204Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi58 ↔ 104By similarity
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi277 ↔ 328By similarity
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi505 ↔ 522By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PRIDEiQ0V8R6.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000017261.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0V8R6.
    SMRiQ0V8R6. Positions 23-528.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni423 – 4242Critical for hydrolyzis GM2 gangliosidesBy similarity

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 20 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3525.
    GeneTreeiENSGT00390000008107.
    HOGENOMiHOG000157972.
    HOVERGENiHBG005961.
    InParanoidiQ0V8R6.
    KOiK12373.
    OMAiWHLVDDS.
    OrthoDBiEOG7KDFB6.
    TreeFamiTF313036.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    3.30.379.10. 1 hit.
    InterProiIPR025705. Beta_hexosaminidase_sua/sub.
    IPR029018. Chitobiase/Hex_dom_2-like.
    IPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR029019. HEX_eukaryotic_N.
    [Graphical view]
    PfamiPF00728. Glyco_hydro_20. 1 hit.
    PF14845. Glycohydro_20b2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
    PRINTSiPR00738. GLHYDRLASE20.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF55545. SSF55545. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0V8R6-1 [UniParc]FASTAAdd to Basket

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    MAGSTLRFSL LLAAAFAGRA TALWPWPQYI QTSELRYTIF PQSFQFQYHL    50
    SSAAQVGCSV LDEAFQRYRD LLFGSVAFRF PHPIEKRHTS EKNSLVVLVV 100
    TPGCDQFPSL GSVENYTLTI NDEQSLLLSE TVWGALRGLE TFSQLIWRSP 150
    EGTFYVNKTD IEDFPRFPHR GLLLDTSRHY LPLASILDTL DVMAYNKFNV 200
    FHWHLVDDSS FPYESFTFPE LTKKGSYNPA THIYTAQDVK EVIEYARLRG 250
    IRVLAEFDTP GHTLSWGPGV PGLLTPCYSG SHPSGTFGPV NPALNNTYEF 300
    MSTFFLEIST VFPDFYLHLG GDEVDFTCWK SNPDIQAFMK KKGFGDDFKK 350
    LESFYIQTLL DIVSAYGKGY VVWQEVFDNK VKVRPDTIIQ VWREEIPVKY 400
    VKELALVTRA GFRALLSAPW YLNHITYGPD WKEIYLVEPL AFEGSPEQKA 450
    LVIGGEACMW GEYVDSTNLV PRLWPRAGAV AERLWSNKMV SNLDFAFKRL 500
    AHFRCELLRR GVQAQPLSVG YCDMEFEQT 529
    Length:529
    Mass (Da):60,353
    Last modified:September 5, 2006 - v1
    Checksum:i878641B502FCD3A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT026152 mRNA. Translation: ABG66991.1.
    RefSeqiNP_001068632.1. NM_001075164.2.
    UniGeneiBt.6065.

    Genome annotation databases

    EnsembliENSBTAT00000017261; ENSBTAP00000017261; ENSBTAG00000012981.
    GeneIDi504468.
    KEGGibta:504468.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT026152 mRNA. Translation: ABG66991.1 .
    RefSeqi NP_001068632.1. NM_001075164.2.
    UniGenei Bt.6065.

    3D structure databases

    ProteinModelPortali Q0V8R6.
    SMRi Q0V8R6. Positions 23-528.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000017261.

    Chemistry

    ChEMBLi CHEMBL1075052.

    Protein family/group databases

    CAZyi GH20. Glycoside Hydrolase Family 20.

    Proteomic databases

    PRIDEi Q0V8R6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000017261 ; ENSBTAP00000017261 ; ENSBTAG00000012981 .
    GeneIDi 504468.
    KEGGi bta:504468.

    Organism-specific databases

    CTDi 3073.

    Phylogenomic databases

    eggNOGi COG3525.
    GeneTreei ENSGT00390000008107.
    HOGENOMi HOG000157972.
    HOVERGENi HBG005961.
    InParanoidi Q0V8R6.
    KOi K12373.
    OMAi WHLVDDS.
    OrthoDBi EOG7KDFB6.
    TreeFami TF313036.

    Enzyme and pathway databases

    Reactomei REACT_204575. Glycosphingolipid metabolism.
    REACT_217191. CS/DS degradation.
    REACT_217291. Keratan sulfate degradation.
    REACT_224746. Hyaluronan uptake and degradation.

    Miscellaneous databases

    NextBioi 20866675.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    3.30.379.10. 1 hit.
    InterProi IPR025705. Beta_hexosaminidase_sua/sub.
    IPR029018. Chitobiase/Hex_dom_2-like.
    IPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR029019. HEX_eukaryotic_N.
    [Graphical view ]
    Pfami PF00728. Glyco_hydro_20. 1 hit.
    PF14845. Glycohydro_20b2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
    PRINTSi PR00738. GLHYDRLASE20.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF55545. SSF55545. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiHEXA_BOVIN
    AccessioniPrimary (citable) accession number: Q0V8R6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3