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Protein

Phospholipase D2

Gene

PLD2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May have a role in signal-induced cytoskeletal regulation and/or endocytosis.By similarity

Catalytic activityi

A phosphatidylcholine + H2O = choline + a phosphatidate.

Enzyme regulationi

Stimulated by phosphatidylinositol 4,5-bisphosphate and activated by the ADP-ribosylation factor-1 (ARF-1).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase D2 (EC:3.1.4.4)
Short name:
PLD 2
Alternative name(s):
Choline phosphatase 2
Phosphatidylcholine-hydrolyzing phospholipase D2
Gene namesi
Name:PLD2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002530381 – 933Phospholipase D2Add BLAST933

Post-translational modificationi

Phosphorylated by FGR.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0V8L6.
PRIDEiQ0V8L6.

Interactioni

Subunit structurei

Interacts with EGFR and PIP5K1B.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035115.

Structurei

3D structure databases

ProteinModelPortaliQ0V8L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 195PXPROSITE-ProRule annotationAdd BLAST131
Domaini203 – 311PHAdd BLAST109
Domaini437 – 464PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST28
Domaini751 – 778PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni441 – 788CatalyticAdd BLAST348

Sequence similaritiesi

Belongs to the phospholipase D family.Curated
Contains 1 PH domain.Curated
Contains 2 PLD phosphodiesterase domains.PROSITE-ProRule annotation
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1329. Eukaryota.
COG1502. LUCA.
HOVERGENiHBG006650.
InParanoidiQ0V8L6.
KOiK01115.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001683. Phox.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
IPR016555. PLipase_D1/D2.
IPR015679. PLipase_D_fam.
[Graphical view]
PANTHERiPTHR18896. PTHR18896. 2 hits.
PfamiPF00614. PLDc. 1 hit.
PF13091. PLDc_2. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
PIRSFiPIRSF009376. Phospholipase_D_euk. 1 hit.
SMARTiSM00155. PLDc. 2 hits.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
PS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0V8L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATPQSLFP SGDDLDSSQL QMEPDEVDTL KEGEDPADRM HPFLAIYHLQ
60 70 80 90 100
PLKLHPLVFA PGVPVIAQVV GTERYTSGSK VGTCTLYSVR LTHGDFTWTT
110 120 130 140 150
KKKFRHFQEL HRDLLRHKVF MSLLPLARFA VASSPAPEGD SREIPSLPRA
160 170 180 190 200
GPEGSSRRTA SKQKYLENYL NRLLTMSFYR NYHAMTEFLE VSQLSFIPDL
210 220 230 240 250
GCKGLEGVIR KRSGGHRVPG LTCCGRDQVC YRWSKRWLVV KDSFLLYMCL
260 270 280 290 300
ETGAISFVQL FDPGFKVQVG KRSTEARYGV RVDTSHRSLI LKCSSYRQAR
310 320 330 340 350
WWAQEITELA QGPGRDFIQL HRHDSYAPPR PGTLARWFVN GAGYFAAVAD
360 370 380 390 400
AILRAQEEIF ITDWWLSPEI YLKRPAHSDD WRLDIMLKKK AEEGVHVSVL
410 420 430 440 450
LFKEVELALA INSGYSKKAL MLLHPNIKVM RHPDQVTLWA HHEKLLVVDQ
460 470 480 490 500
VVAFLGGLDL AYGRWDDLHY RLTDLGDSSE SAAPQPPTSC SDLPATPDLT
510 520 530 540 550
HNQLFWLGKD YSNLITKDWV QLDRPFDDFI DRETMPRMPW RDIGVVVHGS
560 570 580 590 600
PARDLARHFI QRWNFTKTTK TKYKIPIYPY LLPKSTSTAN QLPFTLSGGQ
610 620 630 640 650
CATVQVLRSV DRWSAGTLEN SILNAYLHTI RESQHFLYIE NQFFISCSDG
660 670 680 690 700
RTVLNKVGDE IVDRILKAHK QGQCFRVYVL LPLLPGFEGD ISTGGGNSIQ
710 720 730 740 750
AILHFTYRTL CRGEYSILHR LKAAMGTEWR NYISVCGLRT HGELGGHPVS
760 770 780 790 800
ELIYIHSKML IADDRTVIIG SANINDRSLL GKRDSELAVL IEDTEMEPSL
810 820 830 840 850
MNGVEYQAGR FALSLRKHCF SVILGAAARP HLDLRDPVCD AFFQLWQDTA
860 870 880 890 900
ESNANIYEQI FRCLPSNATR SLRALREYVV VEPLATVSPP LARSELNQVQ
910 920 930
GHLVHFPLKF LEDEYLLPSL GSKEGVMPLE VWT
Length:933
Mass (Da):105,766
Last modified:September 5, 2006 - v1
Checksum:i8B5C417338397455
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT026202 mRNA. Translation: ABG67041.1.
BC123547 mRNA. Translation: AAI23548.1.
RefSeqiNP_001069295.1. NM_001075827.1.
UniGeneiBt.1009.

Genome annotation databases

GeneIDi522159.
KEGGibta:522159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT026202 mRNA. Translation: ABG67041.1.
BC123547 mRNA. Translation: AAI23548.1.
RefSeqiNP_001069295.1. NM_001075827.1.
UniGeneiBt.1009.

3D structure databases

ProteinModelPortaliQ0V8L6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035115.

Proteomic databases

PaxDbiQ0V8L6.
PRIDEiQ0V8L6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi522159.
KEGGibta:522159.

Organism-specific databases

CTDi5338.

Phylogenomic databases

eggNOGiKOG1329. Eukaryota.
COG1502. LUCA.
HOVERGENiHBG006650.
InParanoidiQ0V8L6.
KOiK01115.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001683. Phox.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
IPR016555. PLipase_D1/D2.
IPR015679. PLipase_D_fam.
[Graphical view]
PANTHERiPTHR18896. PTHR18896. 2 hits.
PfamiPF00614. PLDc. 1 hit.
PF13091. PLDc_2. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
PIRSFiPIRSF009376. Phospholipase_D_euk. 1 hit.
SMARTiSM00155. PLDc. 2 hits.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
PS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLD2_BOVIN
AccessioniPrimary (citable) accession number: Q0V8L6
Secondary accession number(s): Q08DV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: September 5, 2006
Last modified: October 5, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.