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Protein

Phospholipase D2

Gene

PLD2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a role in signal-induced cytoskeletal regulation and/or endocytosis.By similarity

Catalytic activityi

A phosphatidylcholine + H2O = choline + a phosphatidate.

Enzyme regulationi

Stimulated by phosphatidylinositol 4,5-bisphosphate and activated by the ADP-ribosylation factor-1 (ARF-1).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase D2 (EC:3.1.4.4)
Short name:
PLD 2
Alternative name(s):
Choline phosphatase 2
Phosphatidylcholine-hydrolyzing phospholipase D2
Gene namesi
Name:PLD2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002530381 – 933Phospholipase D2Add BLAST933

Post-translational modificationi

Phosphorylated by FGR.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0V8L6
PRIDEiQ0V8L6

Interactioni

Subunit structurei

Interacts with EGFR and PIP5K1B.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035115

Structurei

3D structure databases

ProteinModelPortaliQ0V8L6
SMRiQ0V8L6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 195PXPROSITE-ProRule annotationAdd BLAST131
Domaini203 – 311PHAdd BLAST109
Domaini437 – 464PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST28
Domaini751 – 778PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni441 – 788CatalyticAdd BLAST348

Sequence similaritiesi

Belongs to the phospholipase D family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1329 Eukaryota
COG1502 LUCA
HOVERGENiHBG006650
InParanoidiQ0V8L6
KOiK01115

Family and domain databases

Gene3Di2.30.29.30, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001683 Phox
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
IPR016555 PLipase_D_euk
IPR015679 PLipase_D_fam
IPR036871 PX_dom_sf
PANTHERiPTHR18896 PTHR18896, 2 hits
PfamiView protein in Pfam
PF00614 PLDc, 1 hit
PF13091 PLDc_2, 1 hit
PF00787 PX, 1 hit
PIRSFiPIRSF009376 Phospholipase_D_euk, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

Q0V8L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATPQSLFP SGDDLDSSQL QMEPDEVDTL KEGEDPADRM HPFLAIYHLQ
60 70 80 90 100
PLKLHPLVFA PGVPVIAQVV GTERYTSGSK VGTCTLYSVR LTHGDFTWTT
110 120 130 140 150
KKKFRHFQEL HRDLLRHKVF MSLLPLARFA VASSPAPEGD SREIPSLPRA
160 170 180 190 200
GPEGSSRRTA SKQKYLENYL NRLLTMSFYR NYHAMTEFLE VSQLSFIPDL
210 220 230 240 250
GCKGLEGVIR KRSGGHRVPG LTCCGRDQVC YRWSKRWLVV KDSFLLYMCL
260 270 280 290 300
ETGAISFVQL FDPGFKVQVG KRSTEARYGV RVDTSHRSLI LKCSSYRQAR
310 320 330 340 350
WWAQEITELA QGPGRDFIQL HRHDSYAPPR PGTLARWFVN GAGYFAAVAD
360 370 380 390 400
AILRAQEEIF ITDWWLSPEI YLKRPAHSDD WRLDIMLKKK AEEGVHVSVL
410 420 430 440 450
LFKEVELALA INSGYSKKAL MLLHPNIKVM RHPDQVTLWA HHEKLLVVDQ
460 470 480 490 500
VVAFLGGLDL AYGRWDDLHY RLTDLGDSSE SAAPQPPTSC SDLPATPDLT
510 520 530 540 550
HNQLFWLGKD YSNLITKDWV QLDRPFDDFI DRETMPRMPW RDIGVVVHGS
560 570 580 590 600
PARDLARHFI QRWNFTKTTK TKYKIPIYPY LLPKSTSTAN QLPFTLSGGQ
610 620 630 640 650
CATVQVLRSV DRWSAGTLEN SILNAYLHTI RESQHFLYIE NQFFISCSDG
660 670 680 690 700
RTVLNKVGDE IVDRILKAHK QGQCFRVYVL LPLLPGFEGD ISTGGGNSIQ
710 720 730 740 750
AILHFTYRTL CRGEYSILHR LKAAMGTEWR NYISVCGLRT HGELGGHPVS
760 770 780 790 800
ELIYIHSKML IADDRTVIIG SANINDRSLL GKRDSELAVL IEDTEMEPSL
810 820 830 840 850
MNGVEYQAGR FALSLRKHCF SVILGAAARP HLDLRDPVCD AFFQLWQDTA
860 870 880 890 900
ESNANIYEQI FRCLPSNATR SLRALREYVV VEPLATVSPP LARSELNQVQ
910 920 930
GHLVHFPLKF LEDEYLLPSL GSKEGVMPLE VWT
Length:933
Mass (Da):105,766
Last modified:September 5, 2006 - v1
Checksum:i8B5C417338397455
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT026202 mRNA Translation: ABG67041.1
BC123547 mRNA Translation: AAI23548.1
RefSeqiNP_001069295.1, NM_001075827.1
UniGeneiBt.1009

Genome annotation databases

GeneIDi522159
KEGGibta:522159

Similar proteinsi

Entry informationi

Entry nameiPLD2_BOVIN
AccessioniPrimary (citable) accession number: Q0V8L6
Secondary accession number(s): Q08DV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health