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Q0V8L2 (GGT7_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyltransferase 7
Short name=GGT 7
EC=2.3.2.2
Alternative name(s):
Gamma-glutamyltransferase-like 3
Gamma-glutamyltranspeptidase 7

Cleaved into the following 2 chains:

  1. Gamma-glutamyltransferase 7 heavy chain
  2. Gamma-glutamyltransferase 7 light chain
Gene names
Name:GGT7
Synonyms:GGTL3
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length662 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cleaves glutathione conjugates By similarity.

Catalytic activity

(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.

Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathway

Sulfur metabolism; glutathione metabolism.

Subunit structure

Heterodimer composed of the light and heavy chains. The active site is located in the light chain By similarity.

Subcellular location

Membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the gamma-glutamyltransferase family.

Ontologies

Keywords
   Biological processGlutathione biosynthesis
   Cellular componentMembrane
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionAcyltransferase
Transferase
   PTMGlycoprotein
Phosphoprotein
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processglutathione biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functiongamma-glutamyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472Gamma-glutamyltransferase 7 heavy chain By similarity
PRO_0000260258
Chain473 – 662190Gamma-glutamyltransferase 7 light chain By similarity
PRO_0000260259

Regions

Topological domain1 – 106106Cytoplasmic Potential
Transmembrane107 – 12721Helical; Signal-anchor for type II membrane protein; Potential
Topological domain128 – 662535Extracellular Potential

Amino acid modifications

Modified residue721Phosphoserine By similarity
Modified residue831Phosphoserine By similarity
Glycosylation1981N-linked (GlcNAc...) Potential
Glycosylation2671N-linked (GlcNAc...) Potential
Glycosylation2831N-linked (GlcNAc...) Potential
Glycosylation3301N-linked (GlcNAc...) Potential
Glycosylation3531N-linked (GlcNAc...) Potential
Glycosylation3941N-linked (GlcNAc...) Potential
Glycosylation4521N-linked (GlcNAc...) Potential
Glycosylation5191N-linked (GlcNAc...) Potential
Glycosylation5861N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q0V8L2 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 730D755DDB0B8433

FASTA66270,652
        10         20         30         40         50         60 
MAAENEASQE SALGAYSPVD YMSITSFPRL PEDEPAPAVP LRGRKDEDAF LGDPDTDPDS 

        70         80         90        100        110        120 
FLKSARLQRL PSSSSEMGSQ DGSPLRETRK DPFSAAASEC SCRQDGLTVI VTACLTFATG 

       130        140        150        160        170        180 
VTVALIMQIY FGDPQIFHQG AVVTDAARCT SLGIEVLSKQ GSSVDAAVAA ALCLGIVAPH 

       190        200        210        220        230        240 
SSGLGGGGVM LVHDIRRNKS HLIDFRESAP GALREEALQR SWETKPGLLV GVPGMVKGLH 

       250        260        270        280        290        300 
EAHQLYGRLP WSQVLAFAAA VAQDGFNVTH DLAQALAEQP PPNASDRFRE TFLPMGHPPL 

       310        320        330        340        350        360 
PGSLLRRPDL AAVLEVLGTY GPAAFYAGGN LTLEMVAEAQ HAGGVITEED FSNYSALLEK 

       370        380        390        400        410        420 
PVCGVYRGHL VLSPRPPHTG PALISALNIL EGFNLTSLVS REQALHWVAE TLKIALALAS 

       430        440        450        460        470        480 
RLGDPIYDST ITESMDDMLS KVEAAYFRGQ INDSQAAPVP LLPIYELNGA PTAAQVLIMG 

       490        500        510        520        530        540 
PDDFIVAMVS SLNRPFGSGL ITPSGILLNS QMLDFSWPNR TANHPAPSLE NSVQPGKRPL 

       550        560        570        580        590        600 
SFLLPTVVRP AEGLCGTYLA LGANGAARGL SGLTQVLLNV LTLNRNLSDS LARGRLHPDL 

       610        620        630        640        650        660 
QTNLLQVDSE FTEEEIEFLE ARGHHVEKVD VLSWVHGSRR TNNFIIGVKD PRSPDAAGAT 


IL

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References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Basal ganglia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BT026206 mRNA. Translation: ABG67045.1.
BC150107 mRNA. Translation: AAI50108.1.
IPIIPI00724222.
RefSeqNP_001069869.1. NM_001076401.1.
UniGeneBt.26555.

3D structure databases

ProteinModelPortalQ0V8L2.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0V8L2.

Protein family/group databases

MEROPST03.017.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000017688; ENSBTAP00000017688; ENSBTAG00000013301.
GeneID615929.
KEGGbta:615929.

Organism-specific databases

CTD2686.

Phylogenomic databases

HOVERGENHBG039468.
InParanoidQ0V8L2.
OMAVTHDLAR.
OrthoDBEOG483D48.
PhylomeDBQ0V8L2.

Family and domain databases

InterProIPR000101. GGT_peptidase.
[Graphical view]
KOK00681.
PANTHERPTHR11686. GGT_peptidase. 1 hit.
PfamPF01019. G_glu_transpept. 1 hit.
[Graphical view]
PRINTSPR01210. GGTRANSPTASE.
PROSITEPS00462. G_GLU_TRANSPEPTIDASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGGT7_BOVIN
AccessionPrimary (citable) accession number: Q0V8L2
Secondary accession number(s): A6QR42
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: September 5, 2006
Last modified: November 16, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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