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Q0V8H6

- MOV10_BOVIN

UniProt

Q0V8H6 - MOV10_BOVIN

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Protein
Putative helicase MOV-10
Gene
MOV10
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC By similarity.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi524 – 5318ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW
  3. helicase activity Source: UniProtKB-KW

GO - Biological processi

  1. mRNA cleavage involved in gene silencing by miRNA Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

RNA-mediated gene silencing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative helicase MOV-10 (EC:3.6.4.13)
Gene namesi
Name:MOV10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 3

Subcellular locationi

CytoplasmP-body By similarity

GO - Cellular componenti

  1. cytoplasmic mRNA processing body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10031003Putative helicase MOV-10
PRO_0000374666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei148 – 1481N6-acetyllysine By similarity
Modified residuei160 – 1601Phosphothreonine By similarity
Modified residuei254 – 2541Phosphothreonine By similarity
Modified residuei969 – 9691Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ0V8H6.

Interactioni

Subunit structurei

Interacts with DICER1, AGO1, AGO2, EIF6 and TARBP2. Associates with the 60S ribosome By similarity. Interacts with APOBEC3G in an RNA-dependent manner By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018997.

Structurei

3D structure databases

ProteinModelPortaliQ0V8H6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni921 – 96545Interaction with AGO2 and APOBEC3G By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi645 – 6484DEAG box

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1112.
GeneTreeiENSGT00550000074391.
HOGENOMiHOG000239755.
InParanoidiQ0V8H6.
OMAiWFPEKRR.
OrthoDBiEOG74J96Z.
TreeFamiTF323999.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR026122. MOV-10.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10887:SF326. PTHR10887:SF326. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0V8H6-1 [UniParc]FASTAAdd to Basket

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MPSKFSCRQL RETGQRFENF LVDRGQDRET DRERLRTIYN QDFKTSFGTP     50
APGFSSMLYG MKIANLAYVT KTRVRFFGLD RWADVWFPEK RRMKPGLEMS 100
KHHRSLLATI FHDRAEYMHG KHGVNVEVQG PHEARDGQLL IRLDLNRKEV 150
LTLRLRNGGT QPVTLTHLFP FCRTPQFSFC NGDRELPCLL GPGECYELHV 200
HCKTSFVGYF PATVLWELLG PGEPGSEGAG TFYIARFLAA VAHSPLAAQL 250
KPTTPFKRTQ VSRNPVVTRR IEEGERPDRA KNYDLEFSLP LGTYYPPPRL 300
RQLLPVLLRG TSIFTAPKEI AEIKAQLQTT LKWRNYEVKL RLLLHLEELQ 350
MEHDIRHYDL ESVPMTWDPI DRNPRLLTLE VPGVAESRPS VLRGDHLFAL 400
LSSETHHEDP VTYKGFVHKV ELDRVKLSFS TSLLSRFVDG LTFKVNFTFN 450
RQPLRVQHRA LELTGRWPLE PMLFPVASRG VPLLPSDVKL KLYDRSLESN 500
PEQLQAMKHI VMGTTRPAPY IIFGPPGTGK TVTLVEAIKQ VVKHLPKAHI 550
LACAPSNSGA DLLCQRLRVH LPSSIYRLLA PSRDIHLVPE DIKPCCNWDA 600
KKGDFVFPSK KKLQEYRVLI TTLITASRLV SAQFPIDHFT HIFIDEAGHA 650
MEPESLVAIA GLMEVKEADN PGGQLVLAGD PRQLGPVLRC PLTQKHGLGY 700
SLLERLLTFN ALYKKGPDGY NPQFITKLLR NYRSHPTILD VPNRLYYDGE 750
LQACADVVDR ERFCRWEGLP RQDFPIIFHG VMGKDEREGN SPSFFNPEEA 800
ATVTSYLKQL LAPSSKKGKA RLSPRSVGVI SPYRKQVEKI RYCITKLDKQ 850
LRGLDDIKDL KVGSVEEFQG QERSVILIST VRSSQSFVQL DLDFNLGFLK 900
NPKRFNVAVT RAKALLIVVG NPLLLGHDPD WKVFLEFCKE NGGYTGCPFP 950
AKLDLQQGQN LLQGLSKLSP STSGLKSHDY LPQEREGEEG LSLQVEPEWR 1000
NEL 1003
Length:1,003
Mass (Da):113,885
Last modified:September 5, 2006 - v1
Checksum:iEF25709C0B8F7959
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT026242 mRNA. Translation: ABG67081.1.
BC148151 mRNA. Translation: AAI48152.1.
RefSeqiNP_001069307.1. NM_001075839.1.
UniGeneiBt.2939.

Genome annotation databases

EnsembliENSBTAT00000018997; ENSBTAP00000018997; ENSBTAG00000014297.
GeneIDi523206.
KEGGibta:523206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT026242 mRNA. Translation: ABG67081.1 .
BC148151 mRNA. Translation: AAI48152.1 .
RefSeqi NP_001069307.1. NM_001075839.1.
UniGenei Bt.2939.

3D structure databases

ProteinModelPortali Q0V8H6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000018997.

Proteomic databases

PaxDbi Q0V8H6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000018997 ; ENSBTAP00000018997 ; ENSBTAG00000014297 .
GeneIDi 523206.
KEGGi bta:523206.

Organism-specific databases

CTDi 4343.

Phylogenomic databases

eggNOGi COG1112.
GeneTreei ENSGT00550000074391.
HOGENOMi HOG000239755.
InParanoidi Q0V8H6.
OMAi WFPEKRR.
OrthoDBi EOG74J96Z.
TreeFami TF323999.

Miscellaneous databases

NextBioi 20873687.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR026122. MOV-10.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10887:SF326. PTHR10887:SF326. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiMOV10_BOVIN
AccessioniPrimary (citable) accession number: Q0V8H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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