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Q0V8H6

- MOV10_BOVIN

UniProt

Q0V8H6 - MOV10_BOVIN

Protein

Putative helicase MOV-10

Gene

MOV10

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi524 – 5318ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. helicase activity Source: UniProtKB-KW
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA cleavage involved in gene silencing by miRNA Source: UniProtKB

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    RNA-mediated gene silencing

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative helicase MOV-10 (EC:3.6.4.13)
    Gene namesi
    Name:MOV10
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 3

    Subcellular locationi

    CytoplasmP-body By similarity

    GO - Cellular componenti

    1. cytoplasmic mRNA processing body Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10031003Putative helicase MOV-10PRO_0000374666Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei148 – 1481N6-acetyllysineBy similarity
    Modified residuei160 – 1601PhosphothreonineBy similarity
    Modified residuei254 – 2541PhosphothreonineBy similarity
    Modified residuei969 – 9691PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ0V8H6.

    Interactioni

    Subunit structurei

    Interacts with DICER1, AGO1, AGO2, EIF6 and TARBP2. Associates with the 60S ribosome By similarity. Interacts with APOBEC3G in an RNA-dependent manner By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000018997.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0V8H6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni921 – 96545Interaction with AGO2 and APOBEC3GBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi645 – 6484DEAG box

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1112.
    GeneTreeiENSGT00550000074391.
    HOGENOMiHOG000239755.
    InParanoidiQ0V8H6.
    OMAiWFPEKRR.
    OrthoDBiEOG74J96Z.
    TreeFamiTF323999.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR026122. MOV-10.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10887:SF326. PTHR10887:SF326. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0V8H6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSKFSCRQL RETGQRFENF LVDRGQDRET DRERLRTIYN QDFKTSFGTP     50
    APGFSSMLYG MKIANLAYVT KTRVRFFGLD RWADVWFPEK RRMKPGLEMS 100
    KHHRSLLATI FHDRAEYMHG KHGVNVEVQG PHEARDGQLL IRLDLNRKEV 150
    LTLRLRNGGT QPVTLTHLFP FCRTPQFSFC NGDRELPCLL GPGECYELHV 200
    HCKTSFVGYF PATVLWELLG PGEPGSEGAG TFYIARFLAA VAHSPLAAQL 250
    KPTTPFKRTQ VSRNPVVTRR IEEGERPDRA KNYDLEFSLP LGTYYPPPRL 300
    RQLLPVLLRG TSIFTAPKEI AEIKAQLQTT LKWRNYEVKL RLLLHLEELQ 350
    MEHDIRHYDL ESVPMTWDPI DRNPRLLTLE VPGVAESRPS VLRGDHLFAL 400
    LSSETHHEDP VTYKGFVHKV ELDRVKLSFS TSLLSRFVDG LTFKVNFTFN 450
    RQPLRVQHRA LELTGRWPLE PMLFPVASRG VPLLPSDVKL KLYDRSLESN 500
    PEQLQAMKHI VMGTTRPAPY IIFGPPGTGK TVTLVEAIKQ VVKHLPKAHI 550
    LACAPSNSGA DLLCQRLRVH LPSSIYRLLA PSRDIHLVPE DIKPCCNWDA 600
    KKGDFVFPSK KKLQEYRVLI TTLITASRLV SAQFPIDHFT HIFIDEAGHA 650
    MEPESLVAIA GLMEVKEADN PGGQLVLAGD PRQLGPVLRC PLTQKHGLGY 700
    SLLERLLTFN ALYKKGPDGY NPQFITKLLR NYRSHPTILD VPNRLYYDGE 750
    LQACADVVDR ERFCRWEGLP RQDFPIIFHG VMGKDEREGN SPSFFNPEEA 800
    ATVTSYLKQL LAPSSKKGKA RLSPRSVGVI SPYRKQVEKI RYCITKLDKQ 850
    LRGLDDIKDL KVGSVEEFQG QERSVILIST VRSSQSFVQL DLDFNLGFLK 900
    NPKRFNVAVT RAKALLIVVG NPLLLGHDPD WKVFLEFCKE NGGYTGCPFP 950
    AKLDLQQGQN LLQGLSKLSP STSGLKSHDY LPQEREGEEG LSLQVEPEWR 1000
    NEL 1003
    Length:1,003
    Mass (Da):113,885
    Last modified:September 5, 2006 - v1
    Checksum:iEF25709C0B8F7959
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT026242 mRNA. Translation: ABG67081.1.
    BC148151 mRNA. Translation: AAI48152.1.
    RefSeqiNP_001069307.1. NM_001075839.1.
    UniGeneiBt.2939.

    Genome annotation databases

    EnsembliENSBTAT00000018997; ENSBTAP00000018997; ENSBTAG00000014297.
    GeneIDi523206.
    KEGGibta:523206.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT026242 mRNA. Translation: ABG67081.1 .
    BC148151 mRNA. Translation: AAI48152.1 .
    RefSeqi NP_001069307.1. NM_001075839.1.
    UniGenei Bt.2939.

    3D structure databases

    ProteinModelPortali Q0V8H6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000018997.

    Proteomic databases

    PaxDbi Q0V8H6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000018997 ; ENSBTAP00000018997 ; ENSBTAG00000014297 .
    GeneIDi 523206.
    KEGGi bta:523206.

    Organism-specific databases

    CTDi 4343.

    Phylogenomic databases

    eggNOGi COG1112.
    GeneTreei ENSGT00550000074391.
    HOGENOMi HOG000239755.
    InParanoidi Q0V8H6.
    OMAi WFPEKRR.
    OrthoDBi EOG74J96Z.
    TreeFami TF323999.

    Miscellaneous databases

    NextBioi 20873687.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR026122. MOV-10.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10887:SF326. PTHR10887:SF326. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Thymus.

    Entry informationi

    Entry nameiMOV10_BOVIN
    AccessioniPrimary (citable) accession number: Q0V8H6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3