Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q0V8H6 (MOV10_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative helicase MOV-10

EC=3.6.4.13
Gene names
Name:MOV10
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length1003 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Subunit structure

Interacts with DICER1, AGO1, AGO2, EIF6 and TARBP2. Associates with the 60S ribosome By similarity. Interacts with APOBEC3G in an RNA-dependent manner By similarity.

Subcellular location

CytoplasmP-body By similarity.

Sequence similarities

Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10031003Putative helicase MOV-10
PRO_0000374666

Regions

Nucleotide binding524 – 5318ATP By similarity
Region921 – 96545Interaction with AGO2 and APOBEC3G By similarity
Motif645 – 6484DEAG box

Amino acid modifications

Modified residue1481N6-acetyllysine By similarity
Modified residue1601Phosphothreonine By similarity
Modified residue2541Phosphothreonine By similarity
Modified residue9691Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0V8H6 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: EF25709C0B8F7959

FASTA1,003113,885
        10         20         30         40         50         60 
MPSKFSCRQL RETGQRFENF LVDRGQDRET DRERLRTIYN QDFKTSFGTP APGFSSMLYG 

        70         80         90        100        110        120 
MKIANLAYVT KTRVRFFGLD RWADVWFPEK RRMKPGLEMS KHHRSLLATI FHDRAEYMHG 

       130        140        150        160        170        180 
KHGVNVEVQG PHEARDGQLL IRLDLNRKEV LTLRLRNGGT QPVTLTHLFP FCRTPQFSFC 

       190        200        210        220        230        240 
NGDRELPCLL GPGECYELHV HCKTSFVGYF PATVLWELLG PGEPGSEGAG TFYIARFLAA 

       250        260        270        280        290        300 
VAHSPLAAQL KPTTPFKRTQ VSRNPVVTRR IEEGERPDRA KNYDLEFSLP LGTYYPPPRL 

       310        320        330        340        350        360 
RQLLPVLLRG TSIFTAPKEI AEIKAQLQTT LKWRNYEVKL RLLLHLEELQ MEHDIRHYDL 

       370        380        390        400        410        420 
ESVPMTWDPI DRNPRLLTLE VPGVAESRPS VLRGDHLFAL LSSETHHEDP VTYKGFVHKV 

       430        440        450        460        470        480 
ELDRVKLSFS TSLLSRFVDG LTFKVNFTFN RQPLRVQHRA LELTGRWPLE PMLFPVASRG 

       490        500        510        520        530        540 
VPLLPSDVKL KLYDRSLESN PEQLQAMKHI VMGTTRPAPY IIFGPPGTGK TVTLVEAIKQ 

       550        560        570        580        590        600 
VVKHLPKAHI LACAPSNSGA DLLCQRLRVH LPSSIYRLLA PSRDIHLVPE DIKPCCNWDA 

       610        620        630        640        650        660 
KKGDFVFPSK KKLQEYRVLI TTLITASRLV SAQFPIDHFT HIFIDEAGHA MEPESLVAIA 

       670        680        690        700        710        720 
GLMEVKEADN PGGQLVLAGD PRQLGPVLRC PLTQKHGLGY SLLERLLTFN ALYKKGPDGY 

       730        740        750        760        770        780 
NPQFITKLLR NYRSHPTILD VPNRLYYDGE LQACADVVDR ERFCRWEGLP RQDFPIIFHG 

       790        800        810        820        830        840 
VMGKDEREGN SPSFFNPEEA ATVTSYLKQL LAPSSKKGKA RLSPRSVGVI SPYRKQVEKI 

       850        860        870        880        890        900 
RYCITKLDKQ LRGLDDIKDL KVGSVEEFQG QERSVILIST VRSSQSFVQL DLDFNLGFLK 

       910        920        930        940        950        960 
NPKRFNVAVT RAKALLIVVG NPLLLGHDPD WKVFLEFCKE NGGYTGCPFP AKLDLQQGQN 

       970        980        990       1000 
LLQGLSKLSP STSGLKSHDY LPQEREGEEG LSLQVEPEWR NEL 

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thymus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT026242 mRNA. Translation: ABG67081.1.
BC148151 mRNA. Translation: AAI48152.1.
RefSeqNP_001069307.1. NM_001075839.1.
UniGeneBt.2939.

3D structure databases

ProteinModelPortalQ0V8H6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000018997.

Proteomic databases

PaxDbQ0V8H6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000018997; ENSBTAP00000018997; ENSBTAG00000014297.
GeneID523206.
KEGGbta:523206.

Organism-specific databases

CTD4343.

Phylogenomic databases

eggNOGCOG1112.
GeneTreeENSGT00550000074391.
HOGENOMHOG000239755.
InParanoidQ0V8H6.
OMAWFPEKRR.
OrthoDBEOG74J96Z.
TreeFamTF323999.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR026122. MOV-10.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR10887:SF326. PTHR10887:SF326. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

NextBio20873687.

Entry information

Entry nameMOV10_BOVIN
AccessionPrimary (citable) accession number: Q0V8H6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families