Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative helicase MOV-10

Gene

MOV10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable RNA helicase. Required for miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi524 – 531ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processRNA-mediated gene silencing
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative helicase MOV-10 (EC:3.6.4.13)
Gene namesi
Name:MOV10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:31566 MOV10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003746661 – 1003Putative helicase MOV-10Add BLAST1003

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei148N6-acetyllysineBy similarity1
Modified residuei160PhosphothreonineBy similarity1
Modified residuei254PhosphothreonineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei969PhosphoserineBy similarity1
Modified residuei977PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ0V8H6
PeptideAtlasiQ0V8H6
PRIDEiQ0V8H6

Expressioni

Gene expression databases

BgeeiENSBTAG00000014297

Interactioni

Subunit structurei

Interacts with DICER1, AGO2, TARBP2, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC). Interacts with APOBEC3G in an RNA-dependent manner. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018997

Structurei

3D structure databases

ProteinModelPortaliQ0V8H6
SMRiQ0V8H6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni921 – 965Interaction with AGO2 and APOBEC3GBy similarityAdd BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi645 – 648DEAG box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1804 Eukaryota
COG1112 LUCA
GeneTreeiENSGT00800000124068
HOGENOMiHOG000239755
InParanoidiQ0V8H6
KOiK18422
OMAiYNPQFIT
OrthoDBiEOG091G03T8
TreeFamiTF323999

Family and domain databases

InterProiView protein in InterPro
IPR026122 MOV-10
IPR027417 P-loop_NTPase
PANTHERiPTHR10887:SF322 PTHR10887:SF322, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q0V8H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKFSCRQL RETGQRFENF LVDRGQDRET DRERLRTIYN QDFKTSFGTP
60 70 80 90 100
APGFSSMLYG MKIANLAYVT KTRVRFFGLD RWADVWFPEK RRMKPGLEMS
110 120 130 140 150
KHHRSLLATI FHDRAEYMHG KHGVNVEVQG PHEARDGQLL IRLDLNRKEV
160 170 180 190 200
LTLRLRNGGT QPVTLTHLFP FCRTPQFSFC NGDRELPCLL GPGECYELHV
210 220 230 240 250
HCKTSFVGYF PATVLWELLG PGEPGSEGAG TFYIARFLAA VAHSPLAAQL
260 270 280 290 300
KPTTPFKRTQ VSRNPVVTRR IEEGERPDRA KNYDLEFSLP LGTYYPPPRL
310 320 330 340 350
RQLLPVLLRG TSIFTAPKEI AEIKAQLQTT LKWRNYEVKL RLLLHLEELQ
360 370 380 390 400
MEHDIRHYDL ESVPMTWDPI DRNPRLLTLE VPGVAESRPS VLRGDHLFAL
410 420 430 440 450
LSSETHHEDP VTYKGFVHKV ELDRVKLSFS TSLLSRFVDG LTFKVNFTFN
460 470 480 490 500
RQPLRVQHRA LELTGRWPLE PMLFPVASRG VPLLPSDVKL KLYDRSLESN
510 520 530 540 550
PEQLQAMKHI VMGTTRPAPY IIFGPPGTGK TVTLVEAIKQ VVKHLPKAHI
560 570 580 590 600
LACAPSNSGA DLLCQRLRVH LPSSIYRLLA PSRDIHLVPE DIKPCCNWDA
610 620 630 640 650
KKGDFVFPSK KKLQEYRVLI TTLITASRLV SAQFPIDHFT HIFIDEAGHA
660 670 680 690 700
MEPESLVAIA GLMEVKEADN PGGQLVLAGD PRQLGPVLRC PLTQKHGLGY
710 720 730 740 750
SLLERLLTFN ALYKKGPDGY NPQFITKLLR NYRSHPTILD VPNRLYYDGE
760 770 780 790 800
LQACADVVDR ERFCRWEGLP RQDFPIIFHG VMGKDEREGN SPSFFNPEEA
810 820 830 840 850
ATVTSYLKQL LAPSSKKGKA RLSPRSVGVI SPYRKQVEKI RYCITKLDKQ
860 870 880 890 900
LRGLDDIKDL KVGSVEEFQG QERSVILIST VRSSQSFVQL DLDFNLGFLK
910 920 930 940 950
NPKRFNVAVT RAKALLIVVG NPLLLGHDPD WKVFLEFCKE NGGYTGCPFP
960 970 980 990 1000
AKLDLQQGQN LLQGLSKLSP STSGLKSHDY LPQEREGEEG LSLQVEPEWR

NEL
Length:1,003
Mass (Da):113,885
Last modified:September 5, 2006 - v1
Checksum:iEF25709C0B8F7959
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT026242 mRNA Translation: ABG67081.1
BC148151 mRNA Translation: AAI48152.1
RefSeqiNP_001069307.1, NM_001075839.1
UniGeneiBt.2939

Genome annotation databases

EnsembliENSBTAT00000018997; ENSBTAP00000018997; ENSBTAG00000014297
GeneIDi523206
KEGGibta:523206

Similar proteinsi

Entry informationi

Entry nameiMOV10_BOVIN
AccessioniPrimary (citable) accession number: Q0V8H6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health