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Protein

Exocyst complex component 3

Gene

EXOC3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-264876. Insulin processing.
R-BTA-5620916. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 3
Alternative name(s):
Exocyst complex component Sec6
Gene namesi
Name:EXOC3
Synonyms:SEC6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 20

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003273751 – 745Exocyst complex component 3Add BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ0V8C2.
PRIDEiQ0V8C2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000008606.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with MYRIP (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011353.

Structurei

3D structure databases

ProteinModelPortaliQ0V8C2.
SMRiQ0V8C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili614 – 639Sequence analysisAdd BLAST26

Sequence similaritiesi

Belongs to the SEC6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2286. Eukaryota.
COG5173. LUCA.
GeneTreeiENSGT00530000062934.
HOGENOMiHOG000043095.
HOVERGENiHBG034187.
InParanoidiQ0V8C2.
KOiK06110.
OMAiYMIAIIN.
OrthoDBiEOG091G02T2.
TreeFamiTF314979.

Family and domain databases

InterProiView protein in InterPro
IPR010326. EXOC3/Sec6.
PANTHERiPTHR21292. PTHR21292. 1 hit.
PfamiView protein in Pfam
PF06046. Sec6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0V8C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKETDREAVA TAVQRVAGML QRPDQLDKVE QYRRREARKK ASVEARLKAA
60 70 80 90 100
IQSQLDGVRT GLSQLHNALN DVKDIQQSLA DVSKDWRQSI NTIESLKDVK
110 120 130 140 150
DAVVRHSQLA AAVENLKNIF SVPEIVRETQ DLIEHGELLQ AHRKLMDLEC
160 170 180 190 200
SRDGLMYEQY RMDSGNTRDM TLIHSYFGST QGLSDELAKQ LWMVLQRSLV
210 220 230 240 250
TVRRDPTLLV SVVRIIEREE KIDRRILDRK KQTGFVPPGR PKNWKEKMFT
260 270 280 290 300
ILDRTVTTRI EGTQADTRES DRMWLVRHLE IIRKYVLDDL IVAKNLLAQC
310 320 330 340 350
FPPHYEIFRS LLRTYHQALS ARMQDLAAED LEANEIVSLL TWVLNTYTSV
360 370 380 390 400
EMMGNAELAP EVDVALLEPL LSADVVSALL DTYMSTLTSN IIAWLRKALE
410 420 430 440 450
TDKKDWMKET EPEADQDGYY QTTLPAIVFQ MFEQNLQVAA QISEDLKTKV
460 470 480 490 500
LVLCLQQMNS FLSRYKEEAQ LYRDEHLRDR QHPHCYVQYM VAVVNNCQTF
510 520 530 540 550
KESIVSLKRK YLKHEAEEGV SLSQPSMDGV LDAIAKEGCG SLLEEVFLDL
560 570 580 590 600
EQHLNELMTK KWLLGSNAVD IICVTVEDYF NDFAKIKKPY RKRMIAEAHR
610 620 630 640 650
RAVQEYLRAV MQKRISFRSA EERKDGAERM VREAEQLRFL FRKLASGFGE
660 670 680 690 700
EMDSYCDTIV AVAEVIKLTD PSLLYLEVST LVSKYPDIRD DHIGALLAMR
710 720 730 740
GDASRDMKQT IIETLEQGPA QASPDYVPIF KDIVVPSLNV AKLLK
Length:745
Mass (Da):85,581
Last modified:September 5, 2006 - v1
Checksum:i2A0D2E8D27137215
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT026297 mRNA. Translation: ABG81453.1.
RefSeqiNP_001069068.1. NM_001075600.1.
XP_005221718.1. XM_005221661.3.
XP_005221719.1. XM_005221662.3.
XP_005221720.1. XM_005221663.3.
UniGeneiBt.11114.

Genome annotation databases

EnsembliENSBTAT00000011353; ENSBTAP00000011353; ENSBTAG00000008606.
GeneIDi513138.
KEGGibta:513138.

Similar proteinsi

Entry informationi

Entry nameiEXOC3_BOVIN
AccessioniPrimary (citable) accession number: Q0V8C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: September 5, 2006
Last modified: June 7, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families