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Q0V8B6

- TPP1_BOVIN

UniProt

Q0V8B6 - TPP1_BOVIN

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Protein
Tripeptidyl-peptidase 1
Gene
TPP1, CLN2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus By similarity.

Catalytic activityi

Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei272 – 2721Charge relay system By similarity
Active sitei276 – 2761Charge relay system By similarity
Active sitei475 – 4751Charge relay system By similarity
Metal bindingi517 – 5171Calcium By similarity
Metal bindingi518 – 5181Calcium; via carbonyl oxygen By similarity
Metal bindingi539 – 5391Calcium; via carbonyl oxygen By similarity
Metal bindingi541 – 5411Calcium; via carbonyl oxygen By similarity
Metal bindingi543 – 5431Calcium By similarity

GO - Molecular functioni

  1. endopeptidase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. serine-type endopeptidase activity Source: InterPro
  4. tripeptidyl-peptidase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. bone resorption Source: UniProtKB
  2. nervous system development Source: UniProtKB
  3. peptide catabolic process Source: UniProtKB
  4. proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tripeptidyl-peptidase 1 (EC:3.4.14.9)
Short name:
TPP-1
Alternative name(s):
Tripeptidyl aminopeptidase
Tripeptidyl-peptidase I
Short name:
TPP-I
Gene namesi
Name:TPP1
Synonyms:CLN2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Lysosome By similarity. Melanosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB
  2. melanosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarity
Add
BLAST
Propeptidei20 – 195176Removed in mature form By similarity
PRO_0000291586Add
BLAST
Chaini196 – 563368Tripeptidyl-peptidase 1
PRO_0000291587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi111 ↔ 122 By similarity
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi286 – 2861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi313 – 3131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi365 ↔ 526 By similarity
Glycosylationi443 – 4431N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi522 ↔ 537 By similarity

Post-translational modificationi

Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity By similarity.

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ0V8B6.
PRIDEiQ0V8B6.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020469.

Structurei

3D structure databases

ProteinModelPortaliQ0V8B6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini199 – 563365Peptidase S53
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4934.
HOGENOMiHOG000171253.
HOVERGENiHBG004449.
InParanoidiQ0V8B6.
KOiK01279.

Family and domain databases

Gene3Di3.40.50.200. 1 hit.
InterProiIPR015366. Peptidase_S53_propep.
IPR000209. Peptidase_S8/S53_dom.
IPR009020. Prot_inh_propept.
[Graphical view]
PfamiPF00082. Peptidase_S8. 1 hit.
PF09286. Pro-kuma_activ. 1 hit.
[Graphical view]
SMARTiSM00944. Pro-kuma_activ. 1 hit.
[Graphical view]
SUPFAMiSSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS51695. SEDOLISIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0V8B6-1 [UniParc]FASTAAdd to Basket

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MGPRSGLLGL FALFVAGKCS YSPEPDQQRR LPPGWVSLGR ADPEEELSLT    50
FALRQQNVKR LSELVQAVSD PGSPRYGKYL TLEDVAELVR PSPLTLHTVQ 100
KWLLAAGARN CHSVTTQDFL TCWLSVRQAE LLLSGAEFHH YVGGPAETHA 150
VRSLHPYRLP KALAPHVDFV GGLHRFPPTS TLRQHPEPQV PGTVGLHLGV 200
TPSVIRKRYN LTAQDVGSGT TNNSQACAQF LEQYFHDSDL AEFMRLFGGD 250
FAHQASVARV VGQQGRGRAG IEASLDVEYL MSAGANISTW VYSSPGRHES 300
QEPFLQWLLL LSNESALPYV HTVSYGDDED SLSSTYIQRV NTELMKAAAR 350
GLTLLFASGD SGAGCWSVSG RHQFRPSFPA SSPYVTTVGG TSFQNPFRVT 400
DEVVDYISGG GFSNVFPRPS YQEEAVTRYL SSSPHLPPSS YFNASGRAYP 450
DVAALSDGYW VVSNHVPIPW VSGTSASTPV FGGLLSLINE HRILRGLPPL 500
GFLNPRLYQK HGAGLFDVTR GCHESCLNEE VEGQGFCSGP GWDPVTGWGT 550
PNFPALLKTL MNP 563
Length:563
Mass (Da):61,352
Last modified:September 5, 2006 - v1
Checksum:i6D23396D375612C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT026303 mRNA. Translation: ABG81459.1.
BC119827 mRNA. Translation: AAI19828.1.
RefSeqiNP_001069186.1. NM_001075718.1.
UniGeneiBt.35140.

Genome annotation databases

GeneIDi515575.
KEGGibta:515575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT026303 mRNA. Translation: ABG81459.1 .
BC119827 mRNA. Translation: AAI19828.1 .
RefSeqi NP_001069186.1. NM_001075718.1.
UniGenei Bt.35140.

3D structure databases

ProteinModelPortali Q0V8B6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000020469.

Proteomic databases

PaxDbi Q0V8B6.
PRIDEi Q0V8B6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 515575.
KEGGi bta:515575.

Organism-specific databases

CTDi 1200.

Phylogenomic databases

eggNOGi COG4934.
HOGENOMi HOG000171253.
HOVERGENi HBG004449.
InParanoidi Q0V8B6.
KOi K01279.

Miscellaneous databases

NextBioi 20871898.

Family and domain databases

Gene3Di 3.40.50.200. 1 hit.
InterProi IPR015366. Peptidase_S53_propep.
IPR000209. Peptidase_S8/S53_dom.
IPR009020. Prot_inh_propept.
[Graphical view ]
Pfami PF00082. Peptidase_S8. 1 hit.
PF09286. Pro-kuma_activ. 1 hit.
[Graphical view ]
SMARTi SM00944. Pro-kuma_activ. 1 hit.
[Graphical view ]
SUPFAMi SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEi PS51695. SEDOLISIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.

Entry informationi

Entry nameiTPP1_BOVIN
AccessioniPrimary (citable) accession number: Q0V8B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: September 5, 2006
Last modified: January 22, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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