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Q0V7V2

- P2C42_ARATH

UniProt

Q0V7V2 - P2C42_ARATH

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Protein

Probable protein phosphatase 2C 42

Gene

At3g17090

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi89 – 891Manganese 1By similarity
Metal bindingi89 – 891Manganese 2By similarity
Metal bindingi90 – 901Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi290 – 2901Manganese 2By similarity
Metal bindingi349 – 3491Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT3G17090-MONOMER.
ARA:GQT-2235-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 42 (EC:3.1.3.16)
Short name:
AtPP2C42
Gene namesi
Ordered Locus Names:At3g17090
ORF Names:K14A17.16, K14A17.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G17090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Probable protein phosphatase 2C 42PRO_0000367966Add
BLAST

Proteomic databases

PaxDbiQ0V7V2.
PRIDEiQ0V7V2.

Expressioni

Gene expression databases

GenevestigatoriQ0V7V2.

Structurei

3D structure databases

ProteinModelPortaliQ0V7V2.
SMRiQ0V7V2. Positions 83-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 308225PP2C-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 5732Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000238703.
InParanoidiQ0V7V2.
KOiK01102.
OMAiVEIVHNH.
PhylomeDBiQ0V7V2.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q0V7V2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGSLMNLFS LCFKPFGHVC DNSEAGSGGG GGVSGGTGGE GKDGLLWFRD
60 70 80 90 100
LGKYCGGDFS MAVIQANQVL EDQSQVESGN FGTFVGVYDG HGGPEAARYV
110 120 130 140 150
CDHLFNHFRE ISAETQGVVT RETIERAFHA TEEGFASIVS ELWQEIPNLA
160 170 180 190 200
TVGTCCLVGV IYQNTLFVAS LGDSRVVLGK KGNCGGLSAI QLSTEHNANN
210 220 230 240 250
EDIRWELKDL HPDDPQIVVF RHGVWRVKGI IQVSRSIGDM YMKRPEFNKE
260 270 280 290 300
PISQKFRIAE PMKRPLMSAT PTILSHPLHP NDSFLIFASD GLWEHLTNEK
310 320 330 340 350
AVEIVHNHPR AGSAKRLIKA ALHEAARKRE MRYSDLRKID KKVRRHFHDD
360 370 380
ITVIVVFLNH DLISRGHINS TQDTTVSIRS ALEH
Length:384
Mass (Da):42,489
Last modified:September 5, 2006 - v1
Checksum:i5F732834DB387794
GO
Isoform 2 (identifier: Q0V7V2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-316: GSAKR → VTQRD
     317-384: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:316
Mass (Da):34,634
Checksum:i012E6C565B35AE1A
GO

Sequence cautioni

The sequence BAA94987.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391G → R in AAM61747. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei312 – 3165GSAKR → VTQRD in isoform 2. CuratedVSP_036770
Alternative sequencei317 – 38468Missing in isoform 2. CuratedVSP_036771Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026636 Genomic DNA. Translation: BAA94987.1. Different initiation.
CP002686 Genomic DNA. Translation: AEE75902.1.
CP002686 Genomic DNA. Translation: AEE75903.1.
BT026468 mRNA. Translation: ABH04575.1.
AY085196 mRNA. Translation: AAM61747.1.
RefSeqiNP_001030714.1. NM_001035637.1. [Q0V7V2-2]
NP_566566.1. NM_112585.2. [Q0V7V2-1]
UniGeneiAt.6353.
At.67073.

Genome annotation databases

EnsemblPlantsiAT3G17090.1; AT3G17090.1; AT3G17090. [Q0V7V2-1]
GeneIDi820966.
KEGGiath:AT3G17090.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026636 Genomic DNA. Translation: BAA94987.1 . Different initiation.
CP002686 Genomic DNA. Translation: AEE75902.1 .
CP002686 Genomic DNA. Translation: AEE75903.1 .
BT026468 mRNA. Translation: ABH04575.1 .
AY085196 mRNA. Translation: AAM61747.1 .
RefSeqi NP_001030714.1. NM_001035637.1. [Q0V7V2-2 ]
NP_566566.1. NM_112585.2. [Q0V7V2-1 ]
UniGenei At.6353.
At.67073.

3D structure databases

ProteinModelPortali Q0V7V2.
SMRi Q0V7V2. Positions 83-358.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q0V7V2.
PRIDEi Q0V7V2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G17090.1 ; AT3G17090.1 ; AT3G17090 . [Q0V7V2-1 ]
GeneIDi 820966.
KEGGi ath:AT3G17090.

Organism-specific databases

TAIRi AT3G17090.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000238703.
InParanoidi Q0V7V2.
KOi K01102.
OMAi VEIVHNH.
PhylomeDBi Q0V7V2.

Enzyme and pathway databases

BioCyci ARA:AT3G17090-MONOMER.
ARA:GQT-2235-MONOMER.

Gene expression databases

Genevestigatori Q0V7V2.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF Clones."
    Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C42_ARATH
AccessioniPrimary (citable) accession number: Q0V7V2
Secondary accession number(s): Q2V3V2, Q8LEW2, Q9LSN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 5, 2006
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3