Q0V7V2 (P2C42_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable protein phosphatase 2C 42
Short name=AtPP2C42
EC=3.1.3.16

Gene names

Ordered Locus Names:	At3g17090
ORF Names:	K14A17.16, K14A17.4

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 2 magnesium or manganese ions per subunit By similarity.
Sequence similarities	Belongs to the PP2C family. Contains 1 PP2C-like domain.
Sequence caution	The sequence BAA94987.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	Magnesium Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein dephosphorylation Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q0V7V2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q0V7V2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     312-316: GSAKR → VTQRD
     317-384: Missing.

Note: Derived from EST data. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Probable protein phosphatase 2C 42		PRO_0000367966
Regions
	Domain	84 – 308	225	PP2C-like
	Compositional bias	26 – 57	32	Gly-rich
Sites
	Metal binding	89	1	Manganese 1 By similarity
	Metal binding	89	1	Manganese 2 By similarity
	Metal binding	90	1	Manganese 1; via carbonyl oxygen By similarity
	Metal binding	290	1	Manganese 2 By similarity
	Metal binding	349	1	Manganese 2 By similarity
Natural variations
	Alternative sequence	312 – 316	5	GSAKR → VTQRD in isoform 2.		VSP_036770
	Alternative sequence	317 – 384	68	Missing in isoform 2.		VSP_036771
Experimental info
	Sequence conflict	39	1	G → R in AAM61747. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 5F732834DB387794	FASTA	384	42,489
	10 20 30 40 50 60 MSGSLMNLFS LCFKPFGHVC DNSEAGSGGG GGVSGGTGGE GKDGLLWFRD LGKYCGGDFS 70 80 90 100 110 120 MAVIQANQVL EDQSQVESGN FGTFVGVYDG HGGPEAARYV CDHLFNHFRE ISAETQGVVT 130 140 150 160 170 180 RETIERAFHA TEEGFASIVS ELWQEIPNLA TVGTCCLVGV IYQNTLFVAS LGDSRVVLGK 190 200 210 220 230 240 KGNCGGLSAI QLSTEHNANN EDIRWELKDL HPDDPQIVVF RHGVWRVKGI IQVSRSIGDM 250 260 270 280 290 300 YMKRPEFNKE PISQKFRIAE PMKRPLMSAT PTILSHPLHP NDSFLIFASD GLWEHLTNEK 310 320 330 340 350 360 AVEIVHNHPR AGSAKRLIKA ALHEAARKRE MRYSDLRKID KKVRRHFHDD ITVIVVFLNH 370 380 DLISRGHINS TQDTTVSIRS ALEH
	Isoform 2 [UniParc]. Checksum: 012E6C565B35AE1A	FASTA	316	34,634
	10 20 30 40 50 60 MSGSLMNLFS LCFKPFGHVC DNSEAGSGGG GGVSGGTGGE GKDGLLWFRD LGKYCGGDFS 70 80 90 100 110 120 MAVIQANQVL EDQSQVESGN FGTFVGVYDG HGGPEAARYV CDHLFNHFRE ISAETQGVVT 130 140 150 160 170 180 RETIERAFHA TEEGFASIVS ELWQEIPNLA TVGTCCLVGV IYQNTLFVAS LGDSRVVLGK 190 200 210 220 230 240 KGNCGGLSAI QLSTEHNANN EDIRWELKDL HPDDPQIVVF RHGVWRVKGI IQVSRSIGDM 250 260 270 280 290 300 YMKRPEFNKE PISQKFRIAE PMKRPLMSAT PTILSHPLHP NDSFLIFASD GLWEHLTNEK 310 AVEIVHNHPR AVTQRD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S. DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Arabidopsis ORF Clones." Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: cv. Columbia.
[4]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis." Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y. BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB026636 Genomic DNA. Translation: BAA94987.1. Different initiation. CP002686 Genomic DNA. Translation: AEE75902.1. CP002686 Genomic DNA. Translation: AEE75903.1. BT026468 mRNA. Translation: ABH04575.1. AY085196 mRNA. Translation: AAM61747.1.
IPI	IPI00540550. IPI00656542.
RefSeq	NP_001030714.1. NM_001035637.1. NP_566566.1. NM_112585.2.
UniGene	At.6353. At.67073.
3D structure databases
ProteinModelPortal	Q0V7V2.
SMR	Q0V7V2. Positions 83-358.
ModBase	Search...
Proteomic databases
PaxDb	Q0V7V2.
PRIDE	Q0V7V2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT3G17090.1; AT3G17090.1; AT3G17090.
GeneID	820966.
KEGG	ath:AT3G17090.
Organism-specific databases
TAIR	At3g17090.
Phylogenomic databases
eggNOG	COG0631.
HOGENOM	HOG000238703.
InParanoid	Q0V7V2.
OMA	VEIVHNH.
PhylomeDB	Q0V7V2.
ProtClustDB	CLSN2917156.
Gene expression databases
Genevestigator	Q0V7V2.
Family and domain databases
Gene3D	3.60.40.10. 1 hit.
InterPro	IPR001932. PP2C-like. IPR000222. PP2C_Mn2_Asp60_BS. IPR015655. Protein_Pase_2C. [Graphical view]
PANTHER	PTHR13832. PTHR13832. 1 hit.
Pfam	PF00481. PP2C. 1 hit. [Graphical view]
SMART	SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit.
PROSITE	PS01032. PP2C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P2C42_ARATH

Accession

Primary (citable) accession number: Q0V7V2
Secondary accession number(s): Q2V3V2, Q8LEW2, Q9LSN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program