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Q0V7V2 (P2C42_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable protein phosphatase 2C 42

Short name=AtPP2C42
EC=3.1.3.16
Gene names
Ordered Locus Names:At3g17090
ORF Names:K14A17.16, K14A17.4
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Sequence caution

The sequence BAA94987.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q0V7V2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q0V7V2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     312-316: GSAKR → VTQRD
     317-384: Missing.
Note: Derived from EST data. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Probable protein phosphatase 2C 42
PRO_0000367966

Regions

Domain84 – 308225PP2C-like
Compositional bias26 – 5732Gly-rich

Sites

Metal binding891Manganese 1 By similarity
Metal binding891Manganese 2 By similarity
Metal binding901Manganese 1; via carbonyl oxygen By similarity
Metal binding2901Manganese 2 By similarity
Metal binding3491Manganese 2 By similarity

Natural variations

Alternative sequence312 – 3165GSAKR → VTQRD in isoform 2.
VSP_036770
Alternative sequence317 – 38468Missing in isoform 2.
VSP_036771

Experimental info

Sequence conflict391G → R in AAM61747. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 5F732834DB387794

FASTA38442,489
        10         20         30         40         50         60 
MSGSLMNLFS LCFKPFGHVC DNSEAGSGGG GGVSGGTGGE GKDGLLWFRD LGKYCGGDFS 

        70         80         90        100        110        120 
MAVIQANQVL EDQSQVESGN FGTFVGVYDG HGGPEAARYV CDHLFNHFRE ISAETQGVVT 

       130        140        150        160        170        180 
RETIERAFHA TEEGFASIVS ELWQEIPNLA TVGTCCLVGV IYQNTLFVAS LGDSRVVLGK 

       190        200        210        220        230        240 
KGNCGGLSAI QLSTEHNANN EDIRWELKDL HPDDPQIVVF RHGVWRVKGI IQVSRSIGDM 

       250        260        270        280        290        300 
YMKRPEFNKE PISQKFRIAE PMKRPLMSAT PTILSHPLHP NDSFLIFASD GLWEHLTNEK 

       310        320        330        340        350        360 
AVEIVHNHPR AGSAKRLIKA ALHEAARKRE MRYSDLRKID KKVRRHFHDD ITVIVVFLNH 

       370        380 
DLISRGHINS TQDTTVSIRS ALEH 

« Hide

Isoform 2 [UniParc].

Checksum: 012E6C565B35AE1A
Show »

FASTA31634,634

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Arabidopsis ORF Clones."
Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: cv. Columbia.
[4]"Full-length cDNA from Arabidopsis thaliana."
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB026636 Genomic DNA. Translation: BAA94987.1. Different initiation.
CP002686 Genomic DNA. Translation: AEE75902.1.
CP002686 Genomic DNA. Translation: AEE75903.1.
BT026468 mRNA. Translation: ABH04575.1.
AY085196 mRNA. Translation: AAM61747.1.
RefSeqNP_001030714.1. NM_001035637.1.
NP_566566.1. NM_112585.2.
UniGeneAt.6353.
At.67073.

3D structure databases

ProteinModelPortalQ0V7V2.
SMRQ0V7V2. Positions 83-358.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ0V7V2.
PRIDEQ0V7V2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G17090.1; AT3G17090.1; AT3G17090. [Q0V7V2-1]
GeneID820966.
KEGGath:AT3G17090.

Organism-specific databases

TAIRAT3G17090.

Phylogenomic databases

eggNOGCOG0631.
HOGENOMHOG000238703.
InParanoidQ0V7V2.
KOK01102.
OMAVIVLFIN.
PhylomeDBQ0V7V2.
ProtClustDBCLSN2917156.

Enzyme and pathway databases

BioCycARA:AT3G17090-MONOMER.
ARA:GQT-2235-MONOMER.

Gene expression databases

GenevestigatorQ0V7V2.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP2C42_ARATH
AccessionPrimary (citable) accession number: Q0V7V2
Secondary accession number(s): Q2V3V2, Q8LEW2, Q9LSN8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 5, 2006
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names