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Q0V7V2

- P2C42_ARATH

UniProt

Q0V7V2 - P2C42_ARATH

Protein

Probable protein phosphatase 2C 42

Gene

At3g17090

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi89 – 891Manganese 1By similarity
    Metal bindingi89 – 891Manganese 2By similarity
    Metal bindingi90 – 901Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi290 – 2901Manganese 2By similarity
    Metal bindingi349 – 3491Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT3G17090-MONOMER.
    ARA:GQT-2235-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 42 (EC:3.1.3.16)
    Short name:
    AtPP2C42
    Gene namesi
    Ordered Locus Names:At3g17090
    ORF Names:K14A17.16, K14A17.4
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G17090.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Probable protein phosphatase 2C 42PRO_0000367966Add
    BLAST

    Proteomic databases

    PaxDbiQ0V7V2.
    PRIDEiQ0V7V2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ0V7V2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0V7V2.
    SMRiQ0V7V2. Positions 83-358.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini84 – 308225PP2C-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi26 – 5732Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000238703.
    InParanoidiQ0V7V2.
    KOiK01102.
    OMAiVEIVHNH.
    PhylomeDBiQ0V7V2.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q0V7V2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGSLMNLFS LCFKPFGHVC DNSEAGSGGG GGVSGGTGGE GKDGLLWFRD    50
    LGKYCGGDFS MAVIQANQVL EDQSQVESGN FGTFVGVYDG HGGPEAARYV 100
    CDHLFNHFRE ISAETQGVVT RETIERAFHA TEEGFASIVS ELWQEIPNLA 150
    TVGTCCLVGV IYQNTLFVAS LGDSRVVLGK KGNCGGLSAI QLSTEHNANN 200
    EDIRWELKDL HPDDPQIVVF RHGVWRVKGI IQVSRSIGDM YMKRPEFNKE 250
    PISQKFRIAE PMKRPLMSAT PTILSHPLHP NDSFLIFASD GLWEHLTNEK 300
    AVEIVHNHPR AGSAKRLIKA ALHEAARKRE MRYSDLRKID KKVRRHFHDD 350
    ITVIVVFLNH DLISRGHINS TQDTTVSIRS ALEH 384
    Length:384
    Mass (Da):42,489
    Last modified:September 5, 2006 - v1
    Checksum:i5F732834DB387794
    GO
    Isoform 2 (identifier: Q0V7V2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         312-316: GSAKR → VTQRD
         317-384: Missing.

    Note: Derived from EST data. No experimental confirmation available.

    Show »
    Length:316
    Mass (Da):34,634
    Checksum:i012E6C565B35AE1A
    GO

    Sequence cautioni

    The sequence BAA94987.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391G → R in AAM61747. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei312 – 3165GSAKR → VTQRD in isoform 2. CuratedVSP_036770
    Alternative sequencei317 – 38468Missing in isoform 2. CuratedVSP_036771Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026636 Genomic DNA. Translation: BAA94987.1. Different initiation.
    CP002686 Genomic DNA. Translation: AEE75902.1.
    CP002686 Genomic DNA. Translation: AEE75903.1.
    BT026468 mRNA. Translation: ABH04575.1.
    AY085196 mRNA. Translation: AAM61747.1.
    RefSeqiNP_001030714.1. NM_001035637.1. [Q0V7V2-2]
    NP_566566.1. NM_112585.2. [Q0V7V2-1]
    UniGeneiAt.6353.
    At.67073.

    Genome annotation databases

    EnsemblPlantsiAT3G17090.1; AT3G17090.1; AT3G17090. [Q0V7V2-1]
    GeneIDi820966.
    KEGGiath:AT3G17090.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026636 Genomic DNA. Translation: BAA94987.1 . Different initiation.
    CP002686 Genomic DNA. Translation: AEE75902.1 .
    CP002686 Genomic DNA. Translation: AEE75903.1 .
    BT026468 mRNA. Translation: ABH04575.1 .
    AY085196 mRNA. Translation: AAM61747.1 .
    RefSeqi NP_001030714.1. NM_001035637.1. [Q0V7V2-2 ]
    NP_566566.1. NM_112585.2. [Q0V7V2-1 ]
    UniGenei At.6353.
    At.67073.

    3D structure databases

    ProteinModelPortali Q0V7V2.
    SMRi Q0V7V2. Positions 83-358.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q0V7V2.
    PRIDEi Q0V7V2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G17090.1 ; AT3G17090.1 ; AT3G17090 . [Q0V7V2-1 ]
    GeneIDi 820966.
    KEGGi ath:AT3G17090.

    Organism-specific databases

    TAIRi AT3G17090.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000238703.
    InParanoidi Q0V7V2.
    KOi K01102.
    OMAi VEIVHNH.
    PhylomeDBi Q0V7V2.

    Enzyme and pathway databases

    BioCyci ARA:AT3G17090-MONOMER.
    ARA:GQT-2235-MONOMER.

    Gene expression databases

    Genevestigatori Q0V7V2.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
      DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Arabidopsis ORF Clones."
      Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    4. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C42_ARATH
    AccessioniPrimary (citable) accession number: Q0V7V2
    Secondary accession number(s): Q2V3V2, Q8LEW2, Q9LSN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3