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Protein

Probable protein phosphatase 2C 42

Gene

At3g17090

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi89 – 891Manganese 1By similarity
Metal bindingi89 – 891Manganese 2By similarity
Metal bindingi90 – 901Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi290 – 2901Manganese 2By similarity
Metal bindingi349 – 3491Manganese 2By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT3G17090-MONOMER.
ARA:GQT-2235-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 42 (EC:3.1.3.16)
Short name:
AtPP2C42
Gene namesi
Ordered Locus Names:At3g17090
ORF Names:K14A17.16, K14A17.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G17090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Probable protein phosphatase 2C 42PRO_0000367966Add
BLAST

Proteomic databases

PaxDbiQ0V7V2.
PRIDEiQ0V7V2.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G17090.1.

Structurei

3D structure databases

ProteinModelPortaliQ0V7V2.
SMRiQ0V7V2. Positions 83-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 358301PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 5732Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000238703.
InParanoidiQ0V7V2.
KOiK01102.
OMAiSEHNANQ.
PhylomeDBiQ0V7V2.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0V7V2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGSLMNLFS LCFKPFGHVC DNSEAGSGGG GGVSGGTGGE GKDGLLWFRD
60 70 80 90 100
LGKYCGGDFS MAVIQANQVL EDQSQVESGN FGTFVGVYDG HGGPEAARYV
110 120 130 140 150
CDHLFNHFRE ISAETQGVVT RETIERAFHA TEEGFASIVS ELWQEIPNLA
160 170 180 190 200
TVGTCCLVGV IYQNTLFVAS LGDSRVVLGK KGNCGGLSAI QLSTEHNANN
210 220 230 240 250
EDIRWELKDL HPDDPQIVVF RHGVWRVKGI IQVSRSIGDM YMKRPEFNKE
260 270 280 290 300
PISQKFRIAE PMKRPLMSAT PTILSHPLHP NDSFLIFASD GLWEHLTNEK
310 320 330 340 350
AVEIVHNHPR AGSAKRLIKA ALHEAARKRE MRYSDLRKID KKVRRHFHDD
360 370 380
ITVIVVFLNH DLISRGHINS TQDTTVSIRS ALEH
Length:384
Mass (Da):42,489
Last modified:September 5, 2006 - v1
Checksum:i5F732834DB387794
GO
Isoform 2 (identifier: Q0V7V2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-316: GSAKR → VTQRD
     317-384: Missing.

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:316
Mass (Da):34,634
Checksum:i012E6C565B35AE1A
GO

Sequence cautioni

The sequence BAA94987.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391G → R in AAM61747 (Ref. 4) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei312 – 3165GSAKR → VTQRD in isoform 2. CuratedVSP_036770
Alternative sequencei317 – 38468Missing in isoform 2. CuratedVSP_036771Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026636 Genomic DNA. Translation: BAA94987.1. Different initiation.
CP002686 Genomic DNA. Translation: AEE75902.1.
CP002686 Genomic DNA. Translation: AEE75903.1.
BT026468 mRNA. Translation: ABH04575.1.
AY085196 mRNA. Translation: AAM61747.1.
RefSeqiNP_001030714.1. NM_001035637.1. [Q0V7V2-2]
NP_566566.1. NM_112585.2. [Q0V7V2-1]
UniGeneiAt.6353.
At.67073.

Genome annotation databases

EnsemblPlantsiAT3G17090.1; AT3G17090.1; AT3G17090. [Q0V7V2-1]
GeneIDi820966.
KEGGiath:AT3G17090.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026636 Genomic DNA. Translation: BAA94987.1. Different initiation.
CP002686 Genomic DNA. Translation: AEE75902.1.
CP002686 Genomic DNA. Translation: AEE75903.1.
BT026468 mRNA. Translation: ABH04575.1.
AY085196 mRNA. Translation: AAM61747.1.
RefSeqiNP_001030714.1. NM_001035637.1. [Q0V7V2-2]
NP_566566.1. NM_112585.2. [Q0V7V2-1]
UniGeneiAt.6353.
At.67073.

3D structure databases

ProteinModelPortaliQ0V7V2.
SMRiQ0V7V2. Positions 83-358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G17090.1.

Proteomic databases

PaxDbiQ0V7V2.
PRIDEiQ0V7V2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G17090.1; AT3G17090.1; AT3G17090. [Q0V7V2-1]
GeneIDi820966.
KEGGiath:AT3G17090.

Organism-specific databases

TAIRiAT3G17090.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000238703.
InParanoidiQ0V7V2.
KOiK01102.
OMAiSEHNANQ.
PhylomeDBiQ0V7V2.

Enzyme and pathway databases

BioCyciARA:AT3G17090-MONOMER.
ARA:GQT-2235-MONOMER.

Miscellaneous databases

PROiQ0V7V2.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF Clones."
    Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C42_ARATH
AccessioniPrimary (citable) accession number: Q0V7V2
Secondary accession number(s): Q2V3V2, Q8LEW2, Q9LSN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 5, 2006
Last modified: July 22, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.