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Protein

Serine/threonine-protein kinase H1

Gene

PSKH1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activity depends on Ca2+ concentration.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127ATPPROSITE-ProRule annotation1
Active sitei218Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 112ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase H1 (EC:2.7.11.1)
Alternative name(s):
Protein serine kinase H1
Short name:
PSK-H1
Gene namesi
Name:PSKH1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:33437 PSKH1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002929522 – 424Serine/threonine-protein kinase H1Add BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi3S-palmitoyl cysteineBy similarity1
Modified residuei380Phosphoserine; by autocatalysisSequence analysis1
Modified residuei381Phosphoserine; by autocatalysisSequence analysis1

Post-translational modificationi

Autophosphorylated on serine residues.By similarity
Myristoylated. Required for membrane association. Prerequisite for palmitoylation to occur (By similarity).By similarity
Palmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ0V7M1
PRIDEiQ0V7M1

Expressioni

Gene expression databases

BgeeiENSBTAG00000018037

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024011

Structurei

3D structure databases

ProteinModelPortaliQ0V7M1
SMRiQ0V7M1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 355Protein kinasePROSITE-ProRule annotationAdd BLAST258

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118944
HOGENOMiHOG000233016
HOVERGENiHBG108055
InParanoidiQ0V7M1
KOiK08808
OMAiKHPWVVS
OrthoDBiEOG091G0HK9
TreeFamiTF314166

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0V7M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCGTSKVLP EPPKDVQLDL VKKVEPFSGT KSDVYKHFIT EVDSVGPLKG
60 70 80 90 100
GFPAASQGAN PSPGTPRTSH TEPPSEPPRR ARVAKYRAKF DPRVTAKYDI
110 120 130 140 150
KALIGRGSFS RVVRVEHRAT RQPYAIKMIE TKYREGREVC ESELRVLRRV
160 170 180 190 200
RHANIIQLVE VFETQERVYM VMELATGGEL FDRIIAKGSF TERDATRVLQ
210 220 230 240 250
MVLDGVRYLH ALGITHRDLK PENLLYYHPG TDSKIIITDF GLASARKKGD
260 270 280 290 300
DCLMKTTCGT PEYIAPEVLV RKPYTNSVDM WALGVIAYIL LSGTMPFEDD
310 320 330 340 350
NRTRLYRQIL RGKYSYSGEP WPSVSNLAKD FIDRLLTVDP GARMTALQAL
360 370 380 390 400
RHPWVVSMAA SSSMKNLHRS ISQNLLKRAS SRCQSTKSAQ STRSSRSTRS
410 420
NKSRRVRERE LRELNLRYQQ QYNG
Length:424
Mass (Da):48,009
Last modified:September 5, 2006 - v1
Checksum:i83C6943A3BBDCD2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT026549 mRNA Translation: ABH06336.1
RefSeqiNP_001068881.1, NM_001075413.1
UniGeneiBt.2979

Genome annotation databases

EnsembliENSBTAT00000024011; ENSBTAP00000024011; ENSBTAG00000018037
GeneIDi509656
KEGGibta:509656

Similar proteinsi

Entry informationi

Entry nameiKPSH1_BOVIN
AccessioniPrimary (citable) accession number: Q0V7M1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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