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Q0V6M5 (LCPS_PHANO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional lycopene cyclase/phytoene synthase

Including the following 2 domains:

  1. Lycopene beta-cyclase
    EC=5.5.1.19
    Alternative name(s):
    Lycopene cyclase
  2. Phytoene synthase
    EC=2.5.1.32
Gene names
ORF Names:SNOG_00339
OrganismPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) [Reference proteome]
Taxonomic identifier321614 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora

Protein attributes

Sequence length585 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activity

Carotenoid psi-end group = carotenoid beta-end group.

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathway

Carotenoid biosynthesis; beta-carotene biosynthesis.

Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

In the N-terminal section; belongs to the lycopene beta-cyclase family.

In the C-terminal section; belongs to the phytoene/squalene synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 585585Bifunctional lycopene cyclase/phytoene synthase
PRO_0000409238

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane35 – 5521Helical; Potential
Transmembrane75 – 9723Helical; Potential
Transmembrane123 – 14119Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane173 – 19321Helical; Potential
Transmembrane221 – 24121Helical; Potential
Region1 – 243243Lycopene beta-cyclase
Region250 – 585336Phytoene synthase

Sequences

Sequence LengthMass (Da)Tools
Q0V6M5 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: B2689322C5E59549

FASTA58566,047
        10         20         30         40         50         60 
MGFDYAIVHV KYTIPPAVLL TLLYRPLFTK LDAFKVLFLV TVAVTATIPW DSYLIRTNIW 

        70         80         90        100        110        120 
SYPDHVVIGP TLLDIPLEEV FFFFIQTYNT TLLYLILSKP TFQPAYLRAG RPTASSPWKY 

       130        140        150        160        170        180 
QKLAGQLFLV GATVWAGLRV HENAKGTYTG LIVVWAAPII LLQWTLAYQF ILGLPWTNTV 

       190        200        210        220        230        240 
LPIAIPTLYL WLVDTLALRR GTWVISPGTK YGVHLWDGLE IEEALFFFVT NTLIVFGQLA 

       250        260        270        280        290        300 
FDNALAVLYT FPALFPKPPS MPTPLDLINA LWVSPYKYDR ARLAGLQDAV LRLKRKSRSF 

       310        320        330        340        350        360 
YLASATFPGP LRSDLLLLYS FCRVADDLVD NAATAEEAKE WISKLHQYLD LVYSDAKSST 

       370        380        390        400        410        420 
VSEDFVQAHF PSDARSALLQ LPAHKLPRQP LQDLLHGFEM DLAFNTSSPI KTETDLRLYS 

       430        440        450        460        470        480 
ERVAGTVAQM CIELIFRLYP SNMTSGEERK VVDAGNQMGM ALQYVNIARD ISVDAHIGRV 

       490        500        510        520        530        540 
YLPLDWLQES GLTYDEVLIS PEGARMESLR MRLLEKAFSI YDGARGAIET LPVEARGPIR 

       550        560        570        580 
VAVESYMEIG RTLRQKGYTV RAGRATVSKW RRVIVAWRTL NKSIA 

« Hide

References

[1]"Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH445325 Genomic DNA. Translation: EAT91834.1.
RefSeqXP_001791029.1. XM_001790977.1.

3D structure databases

ProteinModelPortalQ0V6M5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSNOT_00339; SNOT_00339; SNOG_00339.
GeneID5968524.
KEGGpno:SNOG_00339.

Phylogenomic databases

KOK17841.
OMAYMEIGRV.
OrthoDBEOG7RBZJ2.

Enzyme and pathway databases

UniPathwayUPA00799; UER00773.
UPA00802.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR03462. CarR_dom_SF. 2 hits.
PROSITEPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLCPS_PHANO
AccessionPrimary (citable) accession number: Q0V6M5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: September 5, 2006
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways