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Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

SNOG_00339

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi: beta-carotene biosynthesis

This protein is involved in the pathway beta-carotene biosynthesis, which is part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway beta-carotene biosynthesis and in Carotenoid biosynthesis.

Pathwayi: phytoene biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional lycopene cyclase/phytoene synthase (SNOG_00339)
This subpathway is part of the pathway phytoene biosynthesis, which is itself part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate, the pathway phytoene biosynthesis and in Carotenoid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Multifunctional enzyme, Transferase
Biological processCarotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773
UPA00802

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
ORF Names:SNOG_00339
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
Proteomesi

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei75 – 97HelicalSequence analysisAdd BLAST23
Transmembranei123 – 141HelicalSequence analysisAdd BLAST19
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004092381 – 585Bifunctional lycopene cyclase/phytoene synthaseAdd BLAST585

Proteomic databases

PRIDEiQ0V6M5

Interactioni

Protein-protein interaction databases

STRINGi13684.SNOT_00339

Structurei

3D structure databases

ProteinModelPortaliQ0V6M5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 243Lycopene beta-cyclaseAdd BLAST243
Regioni250 – 585Phytoene synthaseAdd BLAST336

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ0V6M5
KOiK17841
OMAiYMEIGRV
OrthoDBiEOG092C1GQ8

Family and domain databases

CDDicd00683 Trans_IPPS_HH, 1 hit
Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR017825 Lycopene_cyclase_dom
IPR002060 Squ/phyt_synthse
IPR019845 Squalene/phytoene_synthase_CS
IPR033904 Trans_IPPS_HH
PfamiView protein in Pfam
PF00494 SQS_PSY, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
TIGRFAMsiTIGR03462 CarR_dom_SF, 2 hits
PROSITEiView protein in PROSITE
PS01045 SQUALEN_PHYTOEN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q0V6M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFDYAIVHV KYTIPPAVLL TLLYRPLFTK LDAFKVLFLV TVAVTATIPW
60 70 80 90 100
DSYLIRTNIW SYPDHVVIGP TLLDIPLEEV FFFFIQTYNT TLLYLILSKP
110 120 130 140 150
TFQPAYLRAG RPTASSPWKY QKLAGQLFLV GATVWAGLRV HENAKGTYTG
160 170 180 190 200
LIVVWAAPII LLQWTLAYQF ILGLPWTNTV LPIAIPTLYL WLVDTLALRR
210 220 230 240 250
GTWVISPGTK YGVHLWDGLE IEEALFFFVT NTLIVFGQLA FDNALAVLYT
260 270 280 290 300
FPALFPKPPS MPTPLDLINA LWVSPYKYDR ARLAGLQDAV LRLKRKSRSF
310 320 330 340 350
YLASATFPGP LRSDLLLLYS FCRVADDLVD NAATAEEAKE WISKLHQYLD
360 370 380 390 400
LVYSDAKSST VSEDFVQAHF PSDARSALLQ LPAHKLPRQP LQDLLHGFEM
410 420 430 440 450
DLAFNTSSPI KTETDLRLYS ERVAGTVAQM CIELIFRLYP SNMTSGEERK
460 470 480 490 500
VVDAGNQMGM ALQYVNIARD ISVDAHIGRV YLPLDWLQES GLTYDEVLIS
510 520 530 540 550
PEGARMESLR MRLLEKAFSI YDGARGAIET LPVEARGPIR VAVESYMEIG
560 570 580
RTLRQKGYTV RAGRATVSKW RRVIVAWRTL NKSIA
Length:585
Mass (Da):66,047
Last modified:September 5, 2006 - v1
Checksum:iB2689322C5E59549
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445325 Genomic DNA Translation: EAT91834.1
RefSeqiXP_001791029.1, XM_001790977.1

Genome annotation databases

EnsemblFungiiSNOT_00339; SNOT_00339; SNOG_00339
GeneIDi5968524
KEGGipno:SNOG_00339

Entry informationi

Entry nameiLCPS_PHANO
AccessioniPrimary (citable) accession number: Q0V6M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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