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Q0V6M5

- LCPS_PHANO

UniProt

Q0V6M5 - LCPS_PHANO

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Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

SNOG_00339

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
  2. intramolecular lyase activity Source: InterPro

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
ORF Names:SNOG_00339
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
ProteomesiUP000001055: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence AnalysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Transmembranei75 – 9723HelicalSequence AnalysisAdd
BLAST
Transmembranei123 – 14119HelicalSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Bifunctional lycopene cyclase/phytoene synthasePRO_0000409238Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ0V6M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 243243Lycopene beta-cyclaseAdd
BLAST
Regioni250 – 585336Phytoene synthaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ0V6M5.
KOiK17841.
OMAiYMEIGRV.
OrthoDBiEOG7RBZJ2.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0V6M5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGFDYAIVHV KYTIPPAVLL TLLYRPLFTK LDAFKVLFLV TVAVTATIPW
60 70 80 90 100
DSYLIRTNIW SYPDHVVIGP TLLDIPLEEV FFFFIQTYNT TLLYLILSKP
110 120 130 140 150
TFQPAYLRAG RPTASSPWKY QKLAGQLFLV GATVWAGLRV HENAKGTYTG
160 170 180 190 200
LIVVWAAPII LLQWTLAYQF ILGLPWTNTV LPIAIPTLYL WLVDTLALRR
210 220 230 240 250
GTWVISPGTK YGVHLWDGLE IEEALFFFVT NTLIVFGQLA FDNALAVLYT
260 270 280 290 300
FPALFPKPPS MPTPLDLINA LWVSPYKYDR ARLAGLQDAV LRLKRKSRSF
310 320 330 340 350
YLASATFPGP LRSDLLLLYS FCRVADDLVD NAATAEEAKE WISKLHQYLD
360 370 380 390 400
LVYSDAKSST VSEDFVQAHF PSDARSALLQ LPAHKLPRQP LQDLLHGFEM
410 420 430 440 450
DLAFNTSSPI KTETDLRLYS ERVAGTVAQM CIELIFRLYP SNMTSGEERK
460 470 480 490 500
VVDAGNQMGM ALQYVNIARD ISVDAHIGRV YLPLDWLQES GLTYDEVLIS
510 520 530 540 550
PEGARMESLR MRLLEKAFSI YDGARGAIET LPVEARGPIR VAVESYMEIG
560 570 580
RTLRQKGYTV RAGRATVSKW RRVIVAWRTL NKSIA
Length:585
Mass (Da):66,047
Last modified:September 5, 2006 - v1
Checksum:iB2689322C5E59549
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445325 Genomic DNA. Translation: EAT91834.1.
RefSeqiXP_001791029.1. XM_001790977.1.

Genome annotation databases

EnsemblFungiiSNOT_00339; SNOT_00339; SNOG_00339.
GeneIDi5968524.
KEGGipno:SNOG_00339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445325 Genomic DNA. Translation: EAT91834.1 .
RefSeqi XP_001791029.1. XM_001790977.1.

3D structure databases

ProteinModelPortali Q0V6M5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SNOT_00339 ; SNOT_00339 ; SNOG_00339 .
GeneIDi 5968524.
KEGGi pno:SNOG_00339.

Phylogenomic databases

InParanoidi Q0V6M5.
KOi K17841.
OMAi YMEIGRV.
OrthoDBi EOG7RBZJ2.

Enzyme and pathway databases

UniPathwayi UPA00799 ; UER00773 .
UPA00802 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
    Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
    Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Entry informationi

Entry nameiLCPS_PHANO
AccessioniPrimary (citable) accession number: Q0V6M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3