ID   Q0V466_PHANO            Unreviewed;       940 AA.
AC   Q0V466;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   27-MAR-2024, entry version 127.
DE   RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-36 specific {ECO:0000256|ARBA:ARBA00018028};
DE            EC=2.1.1.359 {ECO:0000256|ARBA:ARBA00012178};
DE   AltName: Full=SET domain-containing protein 2 {ECO:0000256|ARBA:ARBA00030091};
GN   ORFNames=SNOG_01198 {ECO:0000313|EMBL:EAT90847.1};
OS   Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS   blotch fungus) (Parastagonospora nodorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC   Parastagonospora.
OX   NCBI_TaxID=321614 {ECO:0000313|EMBL:EAT90847.1, ECO:0000313|Proteomes:UP000001055};
RN   [1] {ECO:0000313|Proteomes:UP000001055}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173
RC   {ECO:0000313|Proteomes:UP000001055};
RX   PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA   Hane J.K., Lowe R.G., Solomon P.S., Tan K.C., Schoch C.L., Spatafora J.W.,
RA   Crous P.W., Kodira C., Birren B.W., Galagan J.E., Torriani S.F.,
RA   McDonald B.A., Oliver R.P.;
RT   "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT   analysis of the wheat pathogen Stagonospora nodorum.";
RL   Plant Cell 19:3347-3368(2007).
CC   -!- FUNCTION: Histone methyltransferase that trimethylates histone H3 'Lys-
CC       36' forming H3K36me3. Involved in transcription elongation as well as
CC       in transcription repression. {ECO:0000256|ARBA:ARBA00003901}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC         + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:60324, Rhea:RHEA-COMP:9785, Rhea:RHEA-
CC         COMP:15536, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.359;
CC         Evidence={ECO:0000256|ARBA:ARBA00000317};
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; CH445326; EAT90847.1; -; Genomic_DNA.
DR   RefSeq; XP_001791852.1; XM_001791800.1.
DR   AlphaFoldDB; Q0V466; -.
DR   STRING; 321614.Q0V466; -.
DR   EnsemblFungi; SNOT_01198; SNOT_01198; SNOG_01198.
DR   GeneID; 5968697; -.
DR   KEGG; pno:SNOG_01198; -.
DR   VEuPathDB; FungiDB:JI435_011980; -.
DR   eggNOG; KOG4442; Eukaryota.
DR   HOGENOM; CLU_008492_0_1_1; -.
DR   InParanoid; Q0V466; -.
DR   OMA; AQSQPCY; -.
DR   OrthoDB; 950362at2759; -.
DR   Proteomes; UP000001055; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046975; F:histone H3K36 methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0140955; F:histone H3K36 trimethyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   CDD; cd19172; SET_SETD2; 1.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 2.20.70.10; -; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   Gene3D; 1.10.1740.100; Set2, Rpb1 interacting domain; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR025788; Set2_fungi.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR044437; SETD2/Set2_SET.
DR   InterPro; IPR013257; SRI.
DR   InterPro; IPR038190; SRI_sf.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   PANTHER; PTHR22884:SF413; HISTONE-LYSINE N-METHYLTRANSFERASE CG1716-RELATED; 1.
DR   PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR   Pfam; PF17907; AWS; 1.
DR   Pfam; PF08711; Med26; 1.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF08236; SRI; 1.
DR   Pfam; PF00397; WW; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   SUPFAM; SSF51045; WW domain; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS51568; SAM_MT43_SET2_1; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   4: Predicted;
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001055};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ   SEQUENCE   940 AA;  104442 MW;  D454CA968B63FA01 CRC64;
     MESHYDHHEA VADQLPPELD HLKLNATDAE RGSPQVKAEA DRTPTPPLSA IPPRLKTSGS
     RSQSPTYKKQ EESDSPSPAN SVQEETLGGD ITLMVEPGKA PKLSRAASRT VKRAPPLYLD
     LPDSTQDAKQ TFEVLPQCTY ANKHIGTTDP ALECDCGEEW DAVEKVNNAC GEDSDCINRA
     TKMECVADGC SCGTKCQNQR FFRKQYADVT VIKTAKKGFG LRANQDMFPG DFVFEYIGEV
     IDERTFRRRM IQYDEEGIKH FYFMSLTKGE FVDATKKGNL GRFCNHSCNP NCFVDKWVVG
     DKLRMGIFVE RKVKAGEELV FNYNVDRYGA DPQPCYCGEP NCTGYIGGKT QSDNATKLSH
     ATIEALGIDD GDGWDTAVAK KPRKKKVSED DEEYVNDLKP RSLEDDGVPK VMAALRQCTE
     KWIAVKLLSR IQQTDNERVG HRIIRMHGYE TLKKTLTTFM DDFNVVQQVL DILHNLPRIT
     RNKIQDSKIE EAVEQLKTCG NEQVQESASE LLNAWSKLEV AYRIPRMKRD PNAGTPARTE
     NHFERRERGR ERSRSRSKSP SLIAPKGPAA AVPSGPRGVV NVPRGPSGFF NAPRPAPRPR
     PFNPLPPGWF QATSDNGSTY YYNTAGTTQW LRPTQAANQP PPPPPKAKTD TQLLQDIISS
     ITSNATPTGP SASSTPQPTG DEQKEKKTKS EKWRSLPQEK QEKIYEATLS HHVMNVAAHY
     RKKLEKDDIK RLSKEVAKKL VRGDYKSGRV KDPTAKLSSR HEKTVKNYVK EFMDKAVKKK
     EERDKQKAAR AADGRAGSPS AEKEIVDIEE VEWDDDMMDI HKDIAASKDA SPTDSSSELK
     RKREGEEDPG SPKKTRKSTD GLASAPPPPP PPPPASNVVE IDQEYVLLTT GIGHDSSHGI
     AINSKVGLQE NGYPSPVQLA TPSTNGSHQA EQKTAFDDCA
//