Reviewed, UniProtKB/Swiss-Prot Q0UY20 (ATG1_PHANO)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase atg1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	ATG1
ORF Names:	SNOG_03344

Organism

Phaeosphaeria nodorum (Septoria nodorum) [Complete proteome]

Taxonomic identifier

13684 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Pleosporomycetidae › Pleosporales › Phaeosphaeriaceae › Phaeosphaeria

Protein attributes

Sequence length	972 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 972	972	Serine/threonine-protein kinase atg1		PRO_0000317796
Regions
	Domain	30 – 342	313	Protein kinase
	Nucleotide binding	36 – 44	9	ATP By similarity
Sites
	Active site	179	1	Proton acceptor By similarity
	Binding site	65	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0UY20-1 [UniParc]. Last modified February 5, 2008. Version 2. Checksum: ACFA41B40926FA4B	FASTA	972	107,631
	10 20 30 40 50 60 MATPSNPYAP RRSGASPSSS AAAEQIIGKF KRMDHIGKGS FAEVYRGIHI VPNTQQEKRQ 70 80 90 100 110 120 SVAIKSVNMN KLNKKLKDNL VSEISILRSL HHPHIVSLID CHETPSRMHI IMEFCELGDL 130 140 150 160 170 180 SAFIKKRADL VNHPQTQRMI EKYPNPAVGG LNEVIVRHFA KQMASALEFL RSKNYIHRDL 190 200 210 220 230 240 KPQNLLLNPS SVYYSQSGTL ERMPLAADAS SLLPATGIES LPMLKIADFG FARILPTTSL 250 260 270 280 290 300 AETLCGSPLY MAPEILRYEK YDAKADLWSV GTVLFEMMCA RPPFRANNHV ELLRKIEERK 310 320 330 340 350 360 DHIRFPEGIV CSRAMKNLIR ALLKRKPTER MSYDSFFSDP VIREEIPDMV DEDLPQAMQA 370 380 390 400 410 420 SEPEPPVEPP KRVQKMPVEM DRRPSDSPYS RSPRDRTGMG STPPSRPMSR PSSAQAAGTP 430 440 450 460 470 480 PRTLSMRRGS NAPIEPIEEH APLREQRRPV LTNAATAPAR QMPLSEQAMA GHRRRYSRDD 490 500 510 520 530 540 QAPVPSSLKD TERERRTEAG GMREAAERAA QDAALDDGFV FVEKRRVEID ALADEIAVGS 550 560 570 580 590 600 PQTQRDRVSQ RDTMKRRSTT QGAPTSTTGA TAPSKAIQIQ RQPSLTHQRA GSYERRRPYR 610 620 630 640 650 660 PSFESATSAL TKAMNMVSIR GLGLSPPVMK GVSPPQGYSA FPTYPAAQSS LLLVGDNDQV 670 680 690 700 710 720 TTKDEAATTV KKIEELAQLS YVIYGFAEVK YKQLVPVAPS DEGLGIGPGG VRRKPSTDVI 730 740 750 760 770 780 EDDDDDDLTP DTIVTIAEEA LVLYVKTLAL LNKSMDVAGS YWNKHRRGSL SPEAASRAAV 790 800 810 820 830 840 IAERLNRVVS WVRDRFNECC VKSEIIARKL KQAQQHLPTD HPSHPQNLSA ASGSATTVGS 850 860 870 880 890 900 AENILLTTGI TAEKLMYDRA IEMSRSAAVD ELTGHNLPSC DINYSTAAAM LEAILEDEEE 910 920 930 940 950 960 SGSRKLDTEE INGLETEDRQ SIQRLLEEIQ RRHKTLKKKI EIQKAQKRNS ITSAPAGLPS 970 SRGSPSSQGT AR

References

[1]

"Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum." Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P. Plant Cell 19:3347-3368(2007) [PubMed: 18024570] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SN15.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CH445329 Genomic DNA. Translation: EAT88549.2.
RefSeq	XP_001793912.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5970775.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_PHANO

Accession

Primary (citable) accession number: Q0UY20

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	November 25, 2008
This is version 18 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)