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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

SNOG_03803

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionChromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, RNA-bindingPROSITE-ProRule annotation, Transferase
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
ORF Names:SNOG_03803Imported
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)Imported
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
Proteomesi
  • UP000001055 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.UniRule annotation

Protein-protein interaction databases

STRINGi13684.SNOT_03803

Structurei

3D structure databases

ProteinModelPortaliQ0UWR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 251RRMInterPro annotationAdd BLAST91
Domaini1026 – 1143SETInterPro annotationAdd BLAST118
Domaini1152 – 1168Post-SETInterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili774 – 794Sequence analysisAdd BLAST21
Coiled coili947 – 967Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

InParanoidiQ0UWR1
KOiK11422
OMAiHMKKRLK
OrthoDBiEOG092C3T9B

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR024657 COMPASS_Set1_N-SET
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR003616 Post-SET_dom
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR017111 Set1
IPR024636 SET_assoc
IPR001214 SET_dom
PANTHERiPTHR22884:SF462 PTHR22884:SF462, 1 hit
PfamiView protein in Pfam
PF11764 N-SET, 1 hit
PF00076 RRM_1, 1 hit
PF00856 SET, 1 hit
PF11767 SET_assoc, 1 hit
PIRSFiPIRSF037104 Histone_H3-K4_mtfrase_Set1_fun, 2 hits
SMARTiView protein in SMART
SM01291 N-SET, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50868 POST_SET, 1 hit
PS50102 RRM, 1 hit
PS51572 SAM_MT43_1, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

Q0UWR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSGQAISL SALTPLTTSS PSPRSAKTSY DTMNGTSSSR AAPSSAPENV
60 70 80 90 100
ANTITPVNTP PETRKSVFPA DGVMAKRILY DPYSDAKLEK KVRHSKPAQY
110 120 130 140 150
KTVLDKGDPS PPPDPRLALA GYTSGSYILK PTAKSKLRIA PYIAKPYAFD
160 170 180 190 200
NRISCGPGPA TQVVVTGFDP LTPDSQLRGF FSTYGDVESL RAEVHPDNGS
210 220 230 240 250
PLGICLIKFR DTPQARGSVA IKASTSAKRA EREGSNQRLG QQVIKVHTDR
260 270 280 290 300
EGRRCAKLVE LVVQKSRKQE ENIRAKAAAK AAKASALATP ATFDLPANVP
310 320 330 340 350
KGPSGRGARP PIPVPREPLN KKAALSHLIE KDPIKPKLKR APYLFIAHQY
360 370 380 390 400
VPVLSTTIDH LKRRLKNFRW DALRCDQTGY YVVFASTKHG EDEAVRCFRE
410 420 430 440 450
CHMKPLFTYV MNMECQQYGD PDYERSPSPE RVMADKKRKA IEDRMDQEES
460 470 480 490 500
ADLELEKTQR AEAMDPVVAA LEQLKQELQE KILGDIKTRI AAPTLLELMQ
510 520 530 540 550
PERHVEKRRR LNIAEPRKKE EDIRPPSLLV PGLDPFGAGT PKSRAAGFSG
560 570 580 590 600
RGRKALGPYD RNRPGKKPPR IVNAFADERR KASAPKPRVA RGLHRQMIEM
610 620 630 640 650
FEGPEESDDE SRSNLTRGTE EQESRPISRA PSTDVEEEEE ESSRAHRAKR
660 670 680 690 700
RRIEAGWGED SDDEMMDDSH ARSLLAHCIH KDPENMAEKE LEQVLAILPR
710 720 730 740 750
SSPIWKKADK ALKGFRRLRK IEQEADAIFG VETSPVDKLD PEVIVTQDDE
760 770 780 790 800
PSKPIETTEL PETLKSLKKK QAAAKPKKKT KKQLEEEAKS AKAEVTEISL
810 820 830 840 850
PEEDIAEVKE HALVPEVSVT EDTPEEDDTG SVMWGVSSTE PRKTVEDDFS
860 870 880 890 900
VVMDIDGWQH MLKDEEDLLH LKAALQSIEA AKIGDAQSWA WKQKSIKHLN
910 920 930 940 950
RPGGEEGVSR TETKIEGYYV PNPTGSARTE GVKKIRESEK SKYLPHRIRV
960 970 980 990 1000
QREREERQRQ AKKAEHAVIS VEGFKFTTSS QKASTANSRA NRANNRRMVN
1010 1020 1030 1040 1050
DINISKNMTG AEGDALRFNQ LKKRKKLVKF DRSAIHNWGL YAQENIVAND
1060 1070 1080 1090 1100
MIIEYVGEKV RQRVADLREV RYDQQGVGSS YLFRIDEDTV IDATKMGGIA
1110 1120 1130 1140 1150
RFINHSCTPN CTAKIIRVDN TKRIVIYALR DIGQDEELTY DYKFEREMDA
1160
TDRIPCLCGS VGCKGFLN
Length:1,168
Mass (Da):130,831
Last modified:September 5, 2006 - v1
Checksum:i7E8780CBF58846D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445329 Genomic DNA Translation: EAT89008.1
RefSeqiXP_001794349.1, XM_001794297.1

Genome annotation databases

EnsemblFungiiSNOT_03803; SNOT_03803; SNOG_03803
GeneIDi5971212
KEGGipno:SNOG_03803

Similar proteinsi

Entry informationi

Entry nameiQ0UWR1_PHANO
AccessioniPrimary (citable) accession number: Q0UWR1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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