Q0UVK7 (DAPB_PHANO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable dipeptidyl-aminopeptidase B
Short name=DPAP B
EC=3.4.14.5

Gene names

Name:	DAPB
ORF Names:	SNOG_04207

Organism

Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) [Reference proteome]

Taxonomic identifier

321614 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › dothideomyceta › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporineae › Phaeosphaeriaceae › Phaeosphaeria › Phaeosphaeria nodorum

Protein attributes

Sequence length	911 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.
Catalytic activity	Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Subcellular location	Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.
Sequence similarities	Belongs to the peptidase S9B family.

Ontologies

Keywords
Cellular component	Membrane Vacuole
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Aminopeptidase Hydrolase Protease Serine protease
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW vacuolar membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 911	911	Probable dipeptidyl-aminopeptidase B		PRO_0000412158
Regions
	Topological domain	1 – 97	97	Cytoplasmic Potential
	Transmembrane	98 – 118	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	119 – 911	793	Vacuolar Potential
Sites
	Active site	755	1	Charge relay system By similarity
	Active site	832	1	Charge relay system By similarity
	Active site	865	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	268	1	N-linked (GlcNAc...) Potential
	Glycosylation	564	1	N-linked (GlcNAc...) Potential
	Glycosylation	809	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0UVK7 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 2B7D140A51D8324E	FASTA	911	103,088
	10 20 30 40 50 60 MPRPRAAKEE ETELLAQHQE SPRPSSDGSE ASASSISTTS LVLEHINDGG FNGARSKVSE 70 80 90 100 110 120 KYTDDGNGDL GHARERFDIE DGKFHPLTPV DKKARRTLWI VGTICAVGWA LALVSFLMNG 130 140 150 160 170 180 NYKHSSTRPH DPDASVTKGS GKKITLDNVL GGQFYPQSQS VSWIAGPKGE DGLLLEKGVS 190 200 210 220 230 240 GKDYLVVEDI RSKGNTEAAG DKFTLMKKGN FQIGEDIFIY PSNVWPSADF KKVLVMSEQQ 250 260 270 280 290 300 KNWRHSYTGL YWIFDVETQT GEPLDPENQS ARVQYASFSP QSDAVVFTRD NNLYLRKLDS 310 320 330 340 350 360 QKVVKITHDG GSELFYGVPD WVYEEEVFQD NSATWWSEDG KYVAFLRTDE SMVPTYPVQY 370 380 390 400 410 420 FVSRPSGKQP DAGKESYPEV REIKYPKAGA PNPIVTLQFY DIEKSEMFRV DIDNDFTDKD 430 440 450 460 470 480 RLITEIVWAG KSGQVLVRET NRESDILKLI LIDVSKRTGK TIREENVAKL DGGWFEVSHK 490 500 510 520 530 540 TTFIPADSSL GRANDGYIDS VIHEGYDHIG YFTPLDSDKP ILLTKGEWEV VEAPSRVDLK 550 560 570 580 590 600 NNLVYYVSTE RGSMERHPYV VALNGTDKRE VMDHSGPAYY DSSFSTGGGY ALMSYQGPGI 610 620 630 640 650 660 PWQKIVSTPS NTEKFEKVLE ENKALEKMVQ KHELPILKYQ TIDVDGFKLN VLERRPPHFS 670 680 690 700 710 720 EKRKYPVLFY QYSGPGSQQV QRKFEVDFQS YIAANLGYIV VTVDGRGTGF LGRKLRCITR 730 740 750 760 770 780 DNIGYYEAYD QIAAAKMWAA KKYVDAEKLA IWGWSYGGFT TLKTIEMDGG RTFKYGMAVA 790 800 810 820 830 840 PVTDWRFYDS IYTERYMHTP QNNPTGYDNT SITDVHSLSQ NVRFLIMHGV ADDNVHMQNT 850 860 870 880 890 900 LTLLDKLDVA GVENYDVHVF PDSDHSIYFH NAHKIVYDKL TWWLTNAFNG EWLKIQKVRP 910 KAQADARSLG R

References

[1]

"Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum." Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P. Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH445330 Genomic DNA. Translation: EAT87967.1.
RefSeq	XP_001794630.1. XM_001794578.1.
3D structure databases
ProteinModelPortal	Q0UVK7.
ModBase	Search...
Protein family/group databases
MEROPS	S09.006.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SNOT_04207; SNOT_04207; SNOG_04207.
GeneID	5971498.
KEGG	pno:SNOG_04207.
Phylogenomic databases
KO	K01282.
OMA	CVDGRGT.
OrthoDB	EOG4Q885J.
Family and domain databases
InterPro	IPR001375. Peptidase_S9. IPR002469. Peptidase_S9B. [Graphical view]
Pfam	PF00930. DPPIV_N. 1 hit. PF00326. Peptidase_S9. 1 hit. [Graphical view]
PROSITE	PS00708. PRO_ENDOPEP_SER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_PHANO

Accession

Primary (citable) accession number: Q0UVK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	September 5, 2006
Last modified:	March 6, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program