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Q0USX0 (KEX1_PHANO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:SNOG_05144
OrganismPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) [Reference proteome]
Taxonomic identifier321614 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora

Protein attributes

Sequence length642 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 642612Pheromone-processing carboxypeptidase KEX1
PRO_0000411935

Regions

Topological domain31 – 519489Lumenal Potential
Transmembrane520 – 54021Helical; Potential
Topological domain541 – 642102Cytoplasmic Potential

Sites

Active site1841 By similarity
Active site3861 By similarity
Active site4481 By similarity

Amino acid modifications

Glycosylation1201N-linked (GlcNAc...) Potential
Glycosylation4001N-linked (GlcNAc...) Potential
Glycosylation4371N-linked (GlcNAc...) Potential
Glycosylation4451N-linked (GlcNAc...) Potential
Glycosylation4971N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q0USX0 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: C4D96E313AEB1716

FASTA64272,415
        10         20         30         40         50         60 
MLLTHTSSRW RTAAVCALAA TASWLPSVQA AEKTQADYFV SSLPGAPEGP LLKMHAGHIE 

        70         80         90        100        110        120 
VDAEHNSNLF FWHYENRHIA DRQRTVLWLN GGPGCSSMDG AMMEIGPYRV KHGGHLEYNN 

       130        140        150        160        170        180 
GSWDEFANML FIDQPVGTGF SYVNTDSYLT DLDQMAEHMM IFLEKWFKLF PEYENDDLYI 

       190        200        210        220        230        240 
AGESYAGQHI PYIARAILNR NKNQNTDPKP WNLKGLLIGN GWISPADQYL AYLPFAYQNG 

       250        260        270        280        290        300 
MIQADSDSAK RVEQQQSICI QKLQDGGHDK VDTSECEQIM VAILEETKDR KADRMNQCLN 

       310        320        330        340        350        360 
MYDIRLRDDS SCGMNWPPDL TDVTPYLRRP DVIKALHINS DKKTGWSECN GAVSGHFRAK 

       370        380        390        400        410        420 
NSVPTVKFLP ELLTEVPILL FSGDKDFICN HVGTEAMIEN MSWNGGKGWE VSPGVWAPKQ 

       430        440        450        460        470        480 
DWTFEGEPAG TYQEVRNLTY VVFYNSSHMV PFDYPKRTRD MLDRFMNVDI SAIGGDPADS 

       490        500        510        520        530        540 
RIDGEKGPLT SVGDHPNSTK AEEDKAQQLK EAEWKAYYRS GEVVLVILII VACLWGAFLW 

       550        560        570        580        590        600 
RTRRSTSLYK GVDGDEGRES LLTGMGLDNF RRGARRHDVE AADFDERELD DLDDAPKKPA 

       610        620        630        640 
NGYSNVNSEK ERQPHNDSTF SLGADSDDEA EGSERGRRKE HS 

« Hide

References

[1]"Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH445331 Genomic DNA. Translation: EAT87535.1.
RefSeqXP_001795554.1. XM_001795502.1.

3D structure databases

ProteinModelPortalQ0USX0.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSNOT_05144; SNOT_05144; SNOG_05144.
GeneID5972429.
KEGGpno:SNOG_05144.

Phylogenomic databases

KOK01288.
OMADSSHMVP.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_PHANO
AccessionPrimary (citable) accession number: Q0USX0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: September 5, 2006
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries