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Q0USX0

- KEX1_PHANO

UniProt

Q0USX0 - KEX1_PHANO

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei184 – 1841PROSITE-ProRule annotation
Active sitei386 – 3861PROSITE-ProRule annotation
Active sitei448 – 4481PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:SNOG_05144
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
ProteomesiUP000001055: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 642612Pheromone-processing carboxypeptidase KEX1PRO_0000411935Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi445 – 4451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ0USX0.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 519489LumenalSequence AnalysisAdd
BLAST
Topological domaini541 – 642102CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei520 – 54021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ0USX0.
KOiK01288.
OMAiDSSHMVP.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0USX0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLTHTSSRW RTAAVCALAA TASWLPSVQA AEKTQADYFV SSLPGAPEGP
60 70 80 90 100
LLKMHAGHIE VDAEHNSNLF FWHYENRHIA DRQRTVLWLN GGPGCSSMDG
110 120 130 140 150
AMMEIGPYRV KHGGHLEYNN GSWDEFANML FIDQPVGTGF SYVNTDSYLT
160 170 180 190 200
DLDQMAEHMM IFLEKWFKLF PEYENDDLYI AGESYAGQHI PYIARAILNR
210 220 230 240 250
NKNQNTDPKP WNLKGLLIGN GWISPADQYL AYLPFAYQNG MIQADSDSAK
260 270 280 290 300
RVEQQQSICI QKLQDGGHDK VDTSECEQIM VAILEETKDR KADRMNQCLN
310 320 330 340 350
MYDIRLRDDS SCGMNWPPDL TDVTPYLRRP DVIKALHINS DKKTGWSECN
360 370 380 390 400
GAVSGHFRAK NSVPTVKFLP ELLTEVPILL FSGDKDFICN HVGTEAMIEN
410 420 430 440 450
MSWNGGKGWE VSPGVWAPKQ DWTFEGEPAG TYQEVRNLTY VVFYNSSHMV
460 470 480 490 500
PFDYPKRTRD MLDRFMNVDI SAIGGDPADS RIDGEKGPLT SVGDHPNSTK
510 520 530 540 550
AEEDKAQQLK EAEWKAYYRS GEVVLVILII VACLWGAFLW RTRRSTSLYK
560 570 580 590 600
GVDGDEGRES LLTGMGLDNF RRGARRHDVE AADFDERELD DLDDAPKKPA
610 620 630 640
NGYSNVNSEK ERQPHNDSTF SLGADSDDEA EGSERGRRKE HS
Length:642
Mass (Da):72,415
Last modified:September 5, 2006 - v1
Checksum:iC4D96E313AEB1716
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH445331 Genomic DNA. Translation: EAT87535.1.
RefSeqiXP_001795554.1. XM_001795502.1.

Genome annotation databases

EnsemblFungiiSNOT_05144; SNOT_05144; SNOG_05144.
GeneIDi5972429.
KEGGipno:SNOG_05144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH445331 Genomic DNA. Translation: EAT87535.1 .
RefSeqi XP_001795554.1. XM_001795502.1.

3D structure databases

ProteinModelPortali Q0USX0.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SNOT_05144 ; SNOT_05144 ; SNOG_05144 .
GeneIDi 5972429.
KEGGi pno:SNOG_05144.

Phylogenomic databases

InParanoidi Q0USX0.
KOi K01288.
OMAi DSSHMVP.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
    Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
    Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Entry informationi

Entry nameiKEX1_PHANO
AccessioniPrimary (citable) accession number: Q0USX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3