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Q0UJ42

- NTE1_PHANO

UniProt

Q0UJ42 - NTE1_PHANO

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1242 – 12421By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi669 – 793125cNMP 1Add
    BLAST
    Nucleotide bindingi830 – 950121cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    ORF Names:SNOG_08222
    OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
    Taxonomic identifieri321614 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
    ProteomesiUP000001055: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15121512Lysophospholipase NTE1PRO_0000295327Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ0UJ42.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4848CytoplasmicBy similarityAdd
    BLAST
    Topological domaini70 – 8314LumenalBy similarityAdd
    BLAST
    Topological domaini105 – 15121408CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei49 – 6921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1209 – 1373165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1240 – 12445GXSXG

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK14676.
    OMAiSPWTQTC.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 2 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0UJ42-1 [UniParc]FASTAAdd to Basket

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    MAAPDAMTSL VKSSVALLSS AHESLPTSLA AMKTAETAPS STFGILGRVI     50
    LSILSVLPTL LFWVSYTLPT WLFTLFSMSL TFTMNFTTLM LVLVFVVSTI 100
    SYFVRYRYLT MYARLPPEPQ REEPQVEVFP ESQEGDSKRG LSNYLDEFLS 150
    AIKVFGYLER PVFHELTRTM QTRRLAAGET ILLEEEKGFC LVVDGLVQIF 200
    VKSNREESDS DEDDGELQGE SGGGSAQAHR QGYQLLTEVK NGAPMSSLFS 250
    ILSLFTEDVK LRHDEDSGPS SSTPMSPQHR PSMTRNSSFN MDDSRPETPI 300
    EAQEATIRRR RTSALASPTA GGRLSNVPPL SLDTDGFNDN FKHSKQRRSP 350
    SRSTKPKSAH PDIVARATVD TTIAIIPATA FRRLTRIYPK ATAHIVQVIL 400
    TRLQRVTLAT SHAYLSLTNE VLRTEKLMNK YTTYDLPGFL RDAPLERLKE 450
    KFTKETERLG SDEGMKGIAL HNPGAGRRRR TSVSIRSSTA AQARLAAARG 500
    TSIGSNVEAI SRLTSPEQGM RNDRISAGDL LTNTQMSRGT GRSGRSSFSQ 550
    PYQHDVRRDA RTPLDASGFN PFASPSMRPN LHRQESIDEA TVFRESVLGC 600
    MFKAIGLTSP ENPVPRPAAS VEQSPRLVSF DAKRQKAIFT SAFGFMDPYE 650
    ASRDGDADSV ASASNLSTLS ASGNGNLLEE VVNDVEIVFF PKDAVLVEQG 700
    ERNPGLYYVI DGFLDVSVAV EEDSSESNVL GTLPTGPAVT EDDLFGPPLQ 750
    PTATNTSLRN GENSKKKRSR KSLFMTRPGG LAGYLGTVSS NRSFVDVTAK 800
    TDVYVGFLPR ASIERIVERY PVVLLTMAKR LTTLLPRLIQ HIDFALEWVQ 850
    VNAGQVIYNQ GEESDAIYIV LNGRLRAIKD AENGKVTVIG EYGQGDSVGE 900
    LEVLTETARP GSLHAIRDTE LAKFPKTLFN SLALEHPGIT IKISKIIASR 950
    MRALVDDPLH EQSKERSNKA TRTNVSSTVN LRTVAILPVT AGIPVVDFAS 1000
    RLMNALNQIG VPRGVVSLNQ AAILNHLGRH AFNRMGKLKL SQYLADLEEK 1050
    YGMVLYVADT PVKSPWTQTC ISQADCILLV GLAESSPNIG EYERFLLTTK 1100
    TTARKELVLL HAERYCPSGL TRKWLRNWPW INGSHHHMQM SFRATAEPVH 1150
    QTGRRLGNAI KQRVQVIQAE IQKYTSKRVR QTPLYSADTP FKGDFHRLAR 1200
    RLCGKSVGLV LGGGGARGIS QIGIIRALEE AGIPIDIVGG TSIGSFIGAL 1250
    YAWDADVVPM YGRAKKFSGR MGSMWRFALD LTYPSASYTT GHEFNRGIFK 1300
    TFGNSQIEDF WLEFYCNTTN ISKSRSEIHT SGYVWRYVRA SMSLAGLLPP 1350
    LCDNGSMLLD GGYIDNLTVA HMKSLGADVI FAIDVGSLDE DTPQAFGDSL 1400
    SGFWATFNRW NPFSTHANPP TLSEIQSRLA YVSSIDALER AKNTPGCRYM 1450
    RPPIDPYGTL DFAKFEEIYE VGYKYGKGFL AQLREQGVLP VTEETEKEKN 1500
    LRRTMAPRRA SI 1512
    Length:1,512
    Mass (Da):166,935
    Last modified:September 5, 2006 - v1
    Checksum:i330CE41E31FC0E28
    GO

    Sequence cautioni

    The sequence EAT84498.2 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH445336 Genomic DNA. Translation: EAT84498.2. Sequence problems.
    RefSeqiXP_001798544.1. XM_001798492.1.

    Genome annotation databases

    GeneIDi5975442.
    KEGGipno:SNOG_08222.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH445336 Genomic DNA. Translation: EAT84498.2 . Sequence problems.
    RefSeqi XP_001798544.1. XM_001798492.1.

    3D structure databases

    ProteinModelPortali Q0UJ42.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5975442.
    KEGGi pno:SNOG_08222.

    Phylogenomic databases

    KOi K14676.
    OMAi SPWTQTC.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
      Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
      Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

    Entry informationi

    Entry nameiNTE1_PHANO
    AccessioniPrimary (citable) accession number: Q0UJ42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3