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Q0UJ42 (NTE1_PHANO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase NTE1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:NTE1
ORF Names:SNOG_08222
OrganismPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) [Reference proteome]
Taxonomic identifier321614 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora

Protein attributes

Sequence length1512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence caution

The sequence EAT84498.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentEndoplasmic reticulum
Membrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlysophospholipase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15121512Lysophospholipase NTE1
PRO_0000295327

Regions

Topological domain1 – 4848Cytoplasmic By similarity
Transmembrane49 – 6921Helical; Potential
Topological domain70 – 8314Lumenal By similarity
Transmembrane84 – 10421Helical; Potential
Topological domain105 – 15121408Cytoplasmic By similarity
Domain1209 – 1373165Patatin
Nucleotide binding669 – 793125cNMP 1
Nucleotide binding830 – 950121cNMP 2
Motif1240 – 12445GXSXG

Sites

Active site12421 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0UJ42 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 330CE41E31FC0E28

FASTA1,512166,935
        10         20         30         40         50         60 
MAAPDAMTSL VKSSVALLSS AHESLPTSLA AMKTAETAPS STFGILGRVI LSILSVLPTL 

        70         80         90        100        110        120 
LFWVSYTLPT WLFTLFSMSL TFTMNFTTLM LVLVFVVSTI SYFVRYRYLT MYARLPPEPQ 

       130        140        150        160        170        180 
REEPQVEVFP ESQEGDSKRG LSNYLDEFLS AIKVFGYLER PVFHELTRTM QTRRLAAGET 

       190        200        210        220        230        240 
ILLEEEKGFC LVVDGLVQIF VKSNREESDS DEDDGELQGE SGGGSAQAHR QGYQLLTEVK 

       250        260        270        280        290        300 
NGAPMSSLFS ILSLFTEDVK LRHDEDSGPS SSTPMSPQHR PSMTRNSSFN MDDSRPETPI 

       310        320        330        340        350        360 
EAQEATIRRR RTSALASPTA GGRLSNVPPL SLDTDGFNDN FKHSKQRRSP SRSTKPKSAH 

       370        380        390        400        410        420 
PDIVARATVD TTIAIIPATA FRRLTRIYPK ATAHIVQVIL TRLQRVTLAT SHAYLSLTNE 

       430        440        450        460        470        480 
VLRTEKLMNK YTTYDLPGFL RDAPLERLKE KFTKETERLG SDEGMKGIAL HNPGAGRRRR 

       490        500        510        520        530        540 
TSVSIRSSTA AQARLAAARG TSIGSNVEAI SRLTSPEQGM RNDRISAGDL LTNTQMSRGT 

       550        560        570        580        590        600 
GRSGRSSFSQ PYQHDVRRDA RTPLDASGFN PFASPSMRPN LHRQESIDEA TVFRESVLGC 

       610        620        630        640        650        660 
MFKAIGLTSP ENPVPRPAAS VEQSPRLVSF DAKRQKAIFT SAFGFMDPYE ASRDGDADSV 

       670        680        690        700        710        720 
ASASNLSTLS ASGNGNLLEE VVNDVEIVFF PKDAVLVEQG ERNPGLYYVI DGFLDVSVAV 

       730        740        750        760        770        780 
EEDSSESNVL GTLPTGPAVT EDDLFGPPLQ PTATNTSLRN GENSKKKRSR KSLFMTRPGG 

       790        800        810        820        830        840 
LAGYLGTVSS NRSFVDVTAK TDVYVGFLPR ASIERIVERY PVVLLTMAKR LTTLLPRLIQ 

       850        860        870        880        890        900 
HIDFALEWVQ VNAGQVIYNQ GEESDAIYIV LNGRLRAIKD AENGKVTVIG EYGQGDSVGE 

       910        920        930        940        950        960 
LEVLTETARP GSLHAIRDTE LAKFPKTLFN SLALEHPGIT IKISKIIASR MRALVDDPLH 

       970        980        990       1000       1010       1020 
EQSKERSNKA TRTNVSSTVN LRTVAILPVT AGIPVVDFAS RLMNALNQIG VPRGVVSLNQ 

      1030       1040       1050       1060       1070       1080 
AAILNHLGRH AFNRMGKLKL SQYLADLEEK YGMVLYVADT PVKSPWTQTC ISQADCILLV 

      1090       1100       1110       1120       1130       1140 
GLAESSPNIG EYERFLLTTK TTARKELVLL HAERYCPSGL TRKWLRNWPW INGSHHHMQM 

      1150       1160       1170       1180       1190       1200 
SFRATAEPVH QTGRRLGNAI KQRVQVIQAE IQKYTSKRVR QTPLYSADTP FKGDFHRLAR 

      1210       1220       1230       1240       1250       1260 
RLCGKSVGLV LGGGGARGIS QIGIIRALEE AGIPIDIVGG TSIGSFIGAL YAWDADVVPM 

      1270       1280       1290       1300       1310       1320 
YGRAKKFSGR MGSMWRFALD LTYPSASYTT GHEFNRGIFK TFGNSQIEDF WLEFYCNTTN 

      1330       1340       1350       1360       1370       1380 
ISKSRSEIHT SGYVWRYVRA SMSLAGLLPP LCDNGSMLLD GGYIDNLTVA HMKSLGADVI 

      1390       1400       1410       1420       1430       1440 
FAIDVGSLDE DTPQAFGDSL SGFWATFNRW NPFSTHANPP TLSEIQSRLA YVSSIDALER 

      1450       1460       1470       1480       1490       1500 
AKNTPGCRYM RPPIDPYGTL DFAKFEEIYE VGYKYGKGFL AQLREQGVLP VTEETEKEKN 

      1510 
LRRTMAPRRA SI 

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References

[1]"Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH445336 Genomic DNA. Translation: EAT84498.2. Sequence problems.
RefSeqXP_001798544.1. XM_001798492.1.

3D structure databases

ProteinModelPortalQ0UJ42.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5975442.
KEGGpno:SNOG_08222.

Phylogenomic databases

KOK14676.
OMASPWTQTC.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_PHANO
AccessionPrimary (citable) accession number: Q0UJ42
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: September 5, 2006
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families