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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1242NucleophilePROSITE-ProRule annotation1
Active sitei1360Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi669 – 793cNMP 1Add BLAST125
Nucleotide bindingi830 – 950cNMP 2Add BLAST121

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:SNOG_08222
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
Proteomesi
  • UP000001055 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48CytoplasmicBy similarityAdd BLAST48
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 83LumenalBy similarityAdd BLAST14
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 1512CytoplasmicBy similarityAdd BLAST1408

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002953271 – 1512Lysophospholipase NTE1Add BLAST1512

Structurei

3D structure databases

ProteinModelPortaliQ0UJ42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1209 – 1373PNPLAPROSITE-ProRule annotationAdd BLAST165

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1213 – 1218GXGXXGPROSITE-ProRule annotation6
Motifi1240 – 1244GXSXGPROSITE-ProRule annotation5
Motifi1360 – 1362DGA/GPROSITE-ProRule annotation3

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 PNPLA (patatin-like phospholipase) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ0UJ42.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG092C0BAH.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS51635. PNPLA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0UJ42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPDAMTSL VKSSVALLSS AHESLPTSLA AMKTAETAPS STFGILGRVI
60 70 80 90 100
LSILSVLPTL LFWVSYTLPT WLFTLFSMSL TFTMNFTTLM LVLVFVVSTI
110 120 130 140 150
SYFVRYRYLT MYARLPPEPQ REEPQVEVFP ESQEGDSKRG LSNYLDEFLS
160 170 180 190 200
AIKVFGYLER PVFHELTRTM QTRRLAAGET ILLEEEKGFC LVVDGLVQIF
210 220 230 240 250
VKSNREESDS DEDDGELQGE SGGGSAQAHR QGYQLLTEVK NGAPMSSLFS
260 270 280 290 300
ILSLFTEDVK LRHDEDSGPS SSTPMSPQHR PSMTRNSSFN MDDSRPETPI
310 320 330 340 350
EAQEATIRRR RTSALASPTA GGRLSNVPPL SLDTDGFNDN FKHSKQRRSP
360 370 380 390 400
SRSTKPKSAH PDIVARATVD TTIAIIPATA FRRLTRIYPK ATAHIVQVIL
410 420 430 440 450
TRLQRVTLAT SHAYLSLTNE VLRTEKLMNK YTTYDLPGFL RDAPLERLKE
460 470 480 490 500
KFTKETERLG SDEGMKGIAL HNPGAGRRRR TSVSIRSSTA AQARLAAARG
510 520 530 540 550
TSIGSNVEAI SRLTSPEQGM RNDRISAGDL LTNTQMSRGT GRSGRSSFSQ
560 570 580 590 600
PYQHDVRRDA RTPLDASGFN PFASPSMRPN LHRQESIDEA TVFRESVLGC
610 620 630 640 650
MFKAIGLTSP ENPVPRPAAS VEQSPRLVSF DAKRQKAIFT SAFGFMDPYE
660 670 680 690 700
ASRDGDADSV ASASNLSTLS ASGNGNLLEE VVNDVEIVFF PKDAVLVEQG
710 720 730 740 750
ERNPGLYYVI DGFLDVSVAV EEDSSESNVL GTLPTGPAVT EDDLFGPPLQ
760 770 780 790 800
PTATNTSLRN GENSKKKRSR KSLFMTRPGG LAGYLGTVSS NRSFVDVTAK
810 820 830 840 850
TDVYVGFLPR ASIERIVERY PVVLLTMAKR LTTLLPRLIQ HIDFALEWVQ
860 870 880 890 900
VNAGQVIYNQ GEESDAIYIV LNGRLRAIKD AENGKVTVIG EYGQGDSVGE
910 920 930 940 950
LEVLTETARP GSLHAIRDTE LAKFPKTLFN SLALEHPGIT IKISKIIASR
960 970 980 990 1000
MRALVDDPLH EQSKERSNKA TRTNVSSTVN LRTVAILPVT AGIPVVDFAS
1010 1020 1030 1040 1050
RLMNALNQIG VPRGVVSLNQ AAILNHLGRH AFNRMGKLKL SQYLADLEEK
1060 1070 1080 1090 1100
YGMVLYVADT PVKSPWTQTC ISQADCILLV GLAESSPNIG EYERFLLTTK
1110 1120 1130 1140 1150
TTARKELVLL HAERYCPSGL TRKWLRNWPW INGSHHHMQM SFRATAEPVH
1160 1170 1180 1190 1200
QTGRRLGNAI KQRVQVIQAE IQKYTSKRVR QTPLYSADTP FKGDFHRLAR
1210 1220 1230 1240 1250
RLCGKSVGLV LGGGGARGIS QIGIIRALEE AGIPIDIVGG TSIGSFIGAL
1260 1270 1280 1290 1300
YAWDADVVPM YGRAKKFSGR MGSMWRFALD LTYPSASYTT GHEFNRGIFK
1310 1320 1330 1340 1350
TFGNSQIEDF WLEFYCNTTN ISKSRSEIHT SGYVWRYVRA SMSLAGLLPP
1360 1370 1380 1390 1400
LCDNGSMLLD GGYIDNLTVA HMKSLGADVI FAIDVGSLDE DTPQAFGDSL
1410 1420 1430 1440 1450
SGFWATFNRW NPFSTHANPP TLSEIQSRLA YVSSIDALER AKNTPGCRYM
1460 1470 1480 1490 1500
RPPIDPYGTL DFAKFEEIYE VGYKYGKGFL AQLREQGVLP VTEETEKEKN
1510
LRRTMAPRRA SI
Length:1,512
Mass (Da):166,935
Last modified:September 5, 2006 - v1
Checksum:i330CE41E31FC0E28
GO

Sequence cautioni

The sequence EAT84498 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445336 Genomic DNA. Translation: EAT84498.2. Sequence problems.
RefSeqiXP_001798544.1. XM_001798492.1.

Genome annotation databases

GeneIDi5975442.
KEGGipno:SNOG_08222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445336 Genomic DNA. Translation: EAT84498.2. Sequence problems.
RefSeqiXP_001798544.1. XM_001798492.1.

3D structure databases

ProteinModelPortaliQ0UJ42.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5975442.
KEGGipno:SNOG_08222.

Phylogenomic databases

InParanoidiQ0UJ42.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG092C0BAH.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS51635. PNPLA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTE1_PHANO
AccessioniPrimary (citable) accession number: Q0UJ42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: September 5, 2006
Last modified: November 30, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.