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Q0UJ42

- NTE1_PHANO

UniProt

Q0UJ42 - NTE1_PHANO

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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1242 – 12421By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi669 – 793125cNMP 1Add
BLAST
Nucleotide bindingi830 – 950121cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:SNOG_08222
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
ProteomesiUP000001055: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15121512Lysophospholipase NTE1PRO_0000295327Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ0UJ42.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848CytoplasmicBy similarityAdd
BLAST
Topological domaini70 – 8314LumenalBy similarityAdd
BLAST
Topological domaini105 – 15121408CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei49 – 6921HelicalSequence AnalysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1209 – 1373165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1240 – 12445GXSXG

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ0UJ42.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0UJ42-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPDAMTSL VKSSVALLSS AHESLPTSLA AMKTAETAPS STFGILGRVI
60 70 80 90 100
LSILSVLPTL LFWVSYTLPT WLFTLFSMSL TFTMNFTTLM LVLVFVVSTI
110 120 130 140 150
SYFVRYRYLT MYARLPPEPQ REEPQVEVFP ESQEGDSKRG LSNYLDEFLS
160 170 180 190 200
AIKVFGYLER PVFHELTRTM QTRRLAAGET ILLEEEKGFC LVVDGLVQIF
210 220 230 240 250
VKSNREESDS DEDDGELQGE SGGGSAQAHR QGYQLLTEVK NGAPMSSLFS
260 270 280 290 300
ILSLFTEDVK LRHDEDSGPS SSTPMSPQHR PSMTRNSSFN MDDSRPETPI
310 320 330 340 350
EAQEATIRRR RTSALASPTA GGRLSNVPPL SLDTDGFNDN FKHSKQRRSP
360 370 380 390 400
SRSTKPKSAH PDIVARATVD TTIAIIPATA FRRLTRIYPK ATAHIVQVIL
410 420 430 440 450
TRLQRVTLAT SHAYLSLTNE VLRTEKLMNK YTTYDLPGFL RDAPLERLKE
460 470 480 490 500
KFTKETERLG SDEGMKGIAL HNPGAGRRRR TSVSIRSSTA AQARLAAARG
510 520 530 540 550
TSIGSNVEAI SRLTSPEQGM RNDRISAGDL LTNTQMSRGT GRSGRSSFSQ
560 570 580 590 600
PYQHDVRRDA RTPLDASGFN PFASPSMRPN LHRQESIDEA TVFRESVLGC
610 620 630 640 650
MFKAIGLTSP ENPVPRPAAS VEQSPRLVSF DAKRQKAIFT SAFGFMDPYE
660 670 680 690 700
ASRDGDADSV ASASNLSTLS ASGNGNLLEE VVNDVEIVFF PKDAVLVEQG
710 720 730 740 750
ERNPGLYYVI DGFLDVSVAV EEDSSESNVL GTLPTGPAVT EDDLFGPPLQ
760 770 780 790 800
PTATNTSLRN GENSKKKRSR KSLFMTRPGG LAGYLGTVSS NRSFVDVTAK
810 820 830 840 850
TDVYVGFLPR ASIERIVERY PVVLLTMAKR LTTLLPRLIQ HIDFALEWVQ
860 870 880 890 900
VNAGQVIYNQ GEESDAIYIV LNGRLRAIKD AENGKVTVIG EYGQGDSVGE
910 920 930 940 950
LEVLTETARP GSLHAIRDTE LAKFPKTLFN SLALEHPGIT IKISKIIASR
960 970 980 990 1000
MRALVDDPLH EQSKERSNKA TRTNVSSTVN LRTVAILPVT AGIPVVDFAS
1010 1020 1030 1040 1050
RLMNALNQIG VPRGVVSLNQ AAILNHLGRH AFNRMGKLKL SQYLADLEEK
1060 1070 1080 1090 1100
YGMVLYVADT PVKSPWTQTC ISQADCILLV GLAESSPNIG EYERFLLTTK
1110 1120 1130 1140 1150
TTARKELVLL HAERYCPSGL TRKWLRNWPW INGSHHHMQM SFRATAEPVH
1160 1170 1180 1190 1200
QTGRRLGNAI KQRVQVIQAE IQKYTSKRVR QTPLYSADTP FKGDFHRLAR
1210 1220 1230 1240 1250
RLCGKSVGLV LGGGGARGIS QIGIIRALEE AGIPIDIVGG TSIGSFIGAL
1260 1270 1280 1290 1300
YAWDADVVPM YGRAKKFSGR MGSMWRFALD LTYPSASYTT GHEFNRGIFK
1310 1320 1330 1340 1350
TFGNSQIEDF WLEFYCNTTN ISKSRSEIHT SGYVWRYVRA SMSLAGLLPP
1360 1370 1380 1390 1400
LCDNGSMLLD GGYIDNLTVA HMKSLGADVI FAIDVGSLDE DTPQAFGDSL
1410 1420 1430 1440 1450
SGFWATFNRW NPFSTHANPP TLSEIQSRLA YVSSIDALER AKNTPGCRYM
1460 1470 1480 1490 1500
RPPIDPYGTL DFAKFEEIYE VGYKYGKGFL AQLREQGVLP VTEETEKEKN
1510
LRRTMAPRRA SI
Length:1,512
Mass (Da):166,935
Last modified:September 5, 2006 - v1
Checksum:i330CE41E31FC0E28
GO

Sequence cautioni

The sequence EAT84498.2 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH445336 Genomic DNA. Translation: EAT84498.2. Sequence problems.
RefSeqiXP_001798544.1. XM_001798492.1.

Genome annotation databases

GeneIDi5975442.
KEGGipno:SNOG_08222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH445336 Genomic DNA. Translation: EAT84498.2 . Sequence problems.
RefSeqi XP_001798544.1. XM_001798492.1.

3D structure databases

ProteinModelPortali Q0UJ42.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5975442.
KEGGi pno:SNOG_08222.

Phylogenomic databases

InParanoidi Q0UJ42.
KOi K14676.
OMAi SPWTQTC.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
    Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
    Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Entry informationi

Entry nameiNTE1_PHANO
AccessioniPrimary (citable) accession number: Q0UJ42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3