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Q0UJ42

- NTE1_PHANO

UniProt

Q0UJ42 - NTE1_PHANO

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Protein
Lysophospholipase NTE1
Gene
NTE1, SNOG_08222
Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1242 – 12421 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi669 – 793125cNMP 1
Add
BLAST
Nucleotide bindingi830 – 950121cNMP 2
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:SNOG_08222
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
ProteomesiUP000001055: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848Cytoplasmic By similarity
Add
BLAST
Transmembranei49 – 6921Helical; Reviewed prediction
Add
BLAST
Topological domaini70 – 8314Lumenal By similarity
Add
BLAST
Transmembranei84 – 10421Helical; Reviewed prediction
Add
BLAST
Topological domaini105 – 15121408Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15121512Lysophospholipase NTE1
PRO_0000295327Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ0UJ42.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1209 – 1373165Patatin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1240 – 12445GXSXG

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0UJ42-1 [UniParc]FASTAAdd to Basket

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MAAPDAMTSL VKSSVALLSS AHESLPTSLA AMKTAETAPS STFGILGRVI     50
LSILSVLPTL LFWVSYTLPT WLFTLFSMSL TFTMNFTTLM LVLVFVVSTI 100
SYFVRYRYLT MYARLPPEPQ REEPQVEVFP ESQEGDSKRG LSNYLDEFLS 150
AIKVFGYLER PVFHELTRTM QTRRLAAGET ILLEEEKGFC LVVDGLVQIF 200
VKSNREESDS DEDDGELQGE SGGGSAQAHR QGYQLLTEVK NGAPMSSLFS 250
ILSLFTEDVK LRHDEDSGPS SSTPMSPQHR PSMTRNSSFN MDDSRPETPI 300
EAQEATIRRR RTSALASPTA GGRLSNVPPL SLDTDGFNDN FKHSKQRRSP 350
SRSTKPKSAH PDIVARATVD TTIAIIPATA FRRLTRIYPK ATAHIVQVIL 400
TRLQRVTLAT SHAYLSLTNE VLRTEKLMNK YTTYDLPGFL RDAPLERLKE 450
KFTKETERLG SDEGMKGIAL HNPGAGRRRR TSVSIRSSTA AQARLAAARG 500
TSIGSNVEAI SRLTSPEQGM RNDRISAGDL LTNTQMSRGT GRSGRSSFSQ 550
PYQHDVRRDA RTPLDASGFN PFASPSMRPN LHRQESIDEA TVFRESVLGC 600
MFKAIGLTSP ENPVPRPAAS VEQSPRLVSF DAKRQKAIFT SAFGFMDPYE 650
ASRDGDADSV ASASNLSTLS ASGNGNLLEE VVNDVEIVFF PKDAVLVEQG 700
ERNPGLYYVI DGFLDVSVAV EEDSSESNVL GTLPTGPAVT EDDLFGPPLQ 750
PTATNTSLRN GENSKKKRSR KSLFMTRPGG LAGYLGTVSS NRSFVDVTAK 800
TDVYVGFLPR ASIERIVERY PVVLLTMAKR LTTLLPRLIQ HIDFALEWVQ 850
VNAGQVIYNQ GEESDAIYIV LNGRLRAIKD AENGKVTVIG EYGQGDSVGE 900
LEVLTETARP GSLHAIRDTE LAKFPKTLFN SLALEHPGIT IKISKIIASR 950
MRALVDDPLH EQSKERSNKA TRTNVSSTVN LRTVAILPVT AGIPVVDFAS 1000
RLMNALNQIG VPRGVVSLNQ AAILNHLGRH AFNRMGKLKL SQYLADLEEK 1050
YGMVLYVADT PVKSPWTQTC ISQADCILLV GLAESSPNIG EYERFLLTTK 1100
TTARKELVLL HAERYCPSGL TRKWLRNWPW INGSHHHMQM SFRATAEPVH 1150
QTGRRLGNAI KQRVQVIQAE IQKYTSKRVR QTPLYSADTP FKGDFHRLAR 1200
RLCGKSVGLV LGGGGARGIS QIGIIRALEE AGIPIDIVGG TSIGSFIGAL 1250
YAWDADVVPM YGRAKKFSGR MGSMWRFALD LTYPSASYTT GHEFNRGIFK 1300
TFGNSQIEDF WLEFYCNTTN ISKSRSEIHT SGYVWRYVRA SMSLAGLLPP 1350
LCDNGSMLLD GGYIDNLTVA HMKSLGADVI FAIDVGSLDE DTPQAFGDSL 1400
SGFWATFNRW NPFSTHANPP TLSEIQSRLA YVSSIDALER AKNTPGCRYM 1450
RPPIDPYGTL DFAKFEEIYE VGYKYGKGFL AQLREQGVLP VTEETEKEKN 1500
LRRTMAPRRA SI 1512
Length:1,512
Mass (Da):166,935
Last modified:September 5, 2006 - v1
Checksum:i330CE41E31FC0E28
GO

Sequence cautioni

The sequence EAT84498.2 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH445336 Genomic DNA. Translation: EAT84498.2. Sequence problems.
RefSeqiXP_001798544.1. XM_001798492.1.

Genome annotation databases

GeneIDi5975442.
KEGGipno:SNOG_08222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH445336 Genomic DNA. Translation: EAT84498.2 . Sequence problems.
RefSeqi XP_001798544.1. XM_001798492.1.

3D structure databases

ProteinModelPortali Q0UJ42.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5975442.
KEGGi pno:SNOG_08222.

Phylogenomic databases

KOi K14676.
OMAi SPWTQTC.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
    Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
    Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Entry informationi

Entry nameiNTE1_PHANO
AccessioniPrimary (citable) accession number: Q0UJ42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: September 5, 2006
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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