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Q0UIN2

- KYNU1_PHANO

UniProt

Q0UIN2 - KYNU1_PHANO

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Protein

Kynureninase 1

Gene
BNA5-1, SNOG_08382
Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei141 – 1411Pyridoxal phosphate; via amide nitrogen By similarity
Binding sitei142 – 1421Pyridoxal phosphate By similarity
Binding sitei254 – 2541Pyridoxal phosphate By similarity
Binding sitei257 – 2571Pyridoxal phosphate By similarity
Binding sitei279 – 2791Pyridoxal phosphate By similarity
Binding sitei334 – 3341Pyridoxal phosphate By similarity
Binding sitei362 – 3621Pyridoxal phosphate By similarity

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynureninase 1 (EC:3.7.1.3)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5-1
L-kynurenine hydrolase 1
Gene namesi
Name:BNA5-1
ORF Names:SNOG_08382
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
ProteomesiUP000001055: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Kynureninase 1UniRule annotationPRO_0000356982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei280 – 2801N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ0UIN2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni169 – 1724Pyridoxal phosphate binding By similarity

Sequence similaritiesi

Belongs to the kynureninase family.

Phylogenomic databases

KOiK01556.
OMAiGLMNDIV.
OrthoDBiEOG7V1G0J.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0UIN2-1 [UniParc]FASTAAdd to Basket

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MSQTTNSYDS FQDADLCSAA FAEKQDEKDK LTKLREDFYI PTKGDLINKK    50
YGFQKSGNNA KGHENGKCIY FCGNSLGLQP TRTKEYINRY LDTWASKGVF 100
GHFTDYEGGL PPWLHIDDAV KEQTSKIVGA LPSEVVIMET LTANLHLLMS 150
SFYRPTKDRW KIIIEGKAFP SDHYAALSQI AHHDLDPSAL ITIEPPSSSA 200
PYLSNEHILS VISKHAATTA LVLLPGIQFY SGQFFDIELI TRHCRALGIT 250
VGWDLAHAVG NVPLKLHDWN VDFAAWCNYK YMSGGPGVIG GAFVHERHGT 300
VGETAPTTTP DGTNGNPKTI SDESLTYRPR LSGWWGNDKS SRFTMDNKFV 350
PIPGASGYQL SNPSALDMTS VMASLDVFAL TTMDALRERS IRLTGYLEAR 400
LLRYPGGEPP YTIITPTNPA ERGAQLSVML RPGMLDSVLH HLEKEGVVVD 450
ERKPDVLRIA PAPLYNTFRD VHDFIGIFHE ACRKALVKPA EAPKHSEGVP 500
KAIQTT 506
Length:506
Mass (Da):55,984
Last modified:September 5, 2006 - v1
Checksum:i065722108D062DF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH445336 Genomic DNA. Translation: EAT84658.1.
RefSeqiXP_001798697.1. XM_001798645.1.

Genome annotation databases

EnsemblFungiiSNOT_08382; SNOT_08382; SNOG_08382.
GeneIDi5975595.
KEGGipno:SNOG_08382.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH445336 Genomic DNA. Translation: EAT84658.1 .
RefSeqi XP_001798697.1. XM_001798645.1.

3D structure databases

ProteinModelPortali Q0UIN2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SNOT_08382 ; SNOT_08382 ; SNOG_08382 .
GeneIDi 5975595.
KEGGi pno:SNOG_08382.

Phylogenomic databases

KOi K01556.
OMAi GLMNDIV.
OrthoDBi EOG7V1G0J.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
    Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
    Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Entry informationi

Entry nameiKYNU1_PHANO
AccessioniPrimary (citable) accession number: Q0UIN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: September 5, 2006
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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