Q0UFY4 (AMPP1_PHANO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	AMPP
ORF Names:	SNOG_09330

Organism

Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) [Reference proteome]

Taxonomic identifier

321614 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › dothideomyceta › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporineae › Phaeosphaeriaceae › Phaeosphaeria › Phaeosphaeria nodorum

Protein attributes

Sequence length	650 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 650	650	Probable Xaa-Pro aminopeptidase P		PRO_0000411805
Sites
	Metal binding	447	1	Manganese 2 By similarity
	Metal binding	458	1	Manganese 1 By similarity
	Metal binding	458	1	Manganese 2 By similarity
	Metal binding	556	1	Manganese 1 By similarity
	Metal binding	570	1	Manganese 1 By similarity
	Metal binding	570	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0UFY4 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: E1C17EFDC9A294D1	FASTA	650	72,750
	10 20 30 40 50 60 MPRDALSFEL QLSAGLEATE HKLDMLTRLL RRTHVAVKHP LLASRAFHTS PALRAIDMAK 70 80 90 100 110 120 VDTTERLAEL RKLMKERKVD VYTYISGFTG SAGYAVVTHD KAALATDGRY FNQAEKQLDS 130 140 150 160 170 180 NWELLKQGIQ DVPTIQEWTA DQVEGGKVVG VDPSVVTGAD ARKLAEKIKK KGGEYKAVDD 190 200 210 220 230 240 NLVDLVWAAE RPARPSEKVI VQPMEYSGKS FDEKVEDLRK ELEKKKSLGF VVSMLDEVAW 250 260 270 280 290 300 LFNLRGNDIP YNPVFFSYAV ITPTVVTLYV DESKLPKEVK DHLGDKVAIR PYEAIFGDIT 310 320 330 340 350 360 ALSKDAFEAA DADATKKFLT SNRASWALNK ALGGDDKVEE IRSPIGDAKA VKNEVELEGM 370 380 390 400 410 420 RQCHIRDGAA ISEYFAWLED QLLNKKATLD EVDGADKLEA IRKKHDKFMG LSFDTISSTG 430 440 450 460 470 480 PNGAVIHYKP EKGACSIIDP NAIYLCDSGA QYHDGTTDTT RTLHFTKPTD MEKKAYTLVL 490 500 510 520 530 540 KGNIALERVK FPKGTTGFAL DSIARQFLWA EGLDYRHGTG HGVGSFLNVH EGPIGIGTRV 550 560 570 580 590 600 QYSEVSLAVG NVISDEPGYY EDGKFGIRIE NMIMVKEVET NHKFGDKPYL GFEHVTLTPH 610 620 630 640 650 CRNLVDMTLL TEDEKKFIND YHKEVFEKTS KFFENDKLTM DWLKRETAPY

References

[1]

"Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum." Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P. Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH445338 Genomic DNA. Translation: EAT83522.1.
RefSeq	XP_001799625.1. XM_001799573.1.
3D structure databases
ProteinModelPortal	Q0UFY4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SNOT_09330; SNOT_09330; SNOG_09330.
GeneID	5976526.
KEGG	pno:SNOG_09330.
Phylogenomic databases
KO	K01262.
OMA	SRYWEQA.
OrthoDB	EOG45F0XX.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_PHANO

Accession

Primary (citable) accession number: Q0UFY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	September 5, 2006
Last modified:	March 6, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program