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Protein

Mannitol 2-dehydrogenase

Gene

SNOG_09898

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.By similarity

Catalytic activityi

D-mannitol + NAD+ = D-fructose + NADH.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi109 – 12012NADBy similarityAdd
BLAST

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. mannitol 2-dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Mannitol 2-dehydrogenase (EC:1.1.1.67)
Short name:
M2DH
Short name:
MDH
Gene namesi
ORF Names:SNOG_09898
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
ProteomesiUP000001055 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Mannitol 2-dehydrogenasePRO_0000371547Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the mannitol dehydrogenase family.Curated

Phylogenomic databases

InParanoidiQ0UEB6.
KOiK00045.
OMAiCHNPATG.
OrthoDBiEOG7PCJRT.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0UEB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSYLPRYPL RAASARALVR ATRPSYRSAL LRYQSSEAVG RTQEIVPGAY
60 70 80 90 100
QIPPRDFSRQ HEEKLAPKNA ARAPRRIEPA TLKLNSKNLS QLQNVTVPTY
110 120 130 140 150
QREGVKQGIV HVGVGGFHRA HLAAYVDTLL EQFNSQDWSI CGVDLQPFAA
160 170 180 190 200
PMRDALGSQD NLYTMIECDT EGTSARVIGS ITDYLFAPDN CEAVIAKMAH
210 220 230 240 250
PDTHIVSMTV TESGYYMNEN THELQIDHPD IAADLAGQQP PRTVFAYLYA
260 270 280 290 300
ALARRHAAGL RPFTVMSCDN MQKNGDISRN MLLAFARQQN PEVADWIAEN
310 320 330 340 350
GAFPNSMVDR ITPRTSDENK AQLAQEFGVE DSWPVVTEVF HQWVLEDKFA
360 370 380 390 400
DGRPPFEKAG VQVVPNVHKV EEYELIKLRL LNASHSAMGY AGYLGGFTYI
410 420 430 440 450
HEVIADPTFR KYIRNMMQEE VQPLLPRIPG VSVDDYCNTL LGRFSNPTLK
460 470 480 490 500
DELPRICLGG SGKIPQFIMP SIAEQIQAGG PLRRLTLCAA AWFRYLRGIN
510 520 530 540 550
EQGQAFKLDD PMAEELQAKA LESPFSVLEV KSLFGDDLRD DKRFVAELKN
560
ALESLERDGA RATIAQYA
Length:568
Mass (Da):63,495
Last modified:September 5, 2006 - v1
Checksum:iBF3CECA2C4156C92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445339 Genomic DNA. Translation: EAT83163.1.
RefSeqiXP_001800184.1. XM_001800132.1.

Genome annotation databases

EnsemblFungiiSNOT_09898; SNOT_09898; SNOG_09898.
GeneIDi5977089.
KEGGipno:SNOG_09898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445339 Genomic DNA. Translation: EAT83163.1.
RefSeqiXP_001800184.1. XM_001800132.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSNOT_09898; SNOT_09898; SNOG_09898.
GeneIDi5977089.
KEGGipno:SNOG_09898.

Phylogenomic databases

InParanoidiQ0UEB6.
KOiK00045.
OMAiCHNPATG.
OrthoDBiEOG7PCJRT.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
    Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
    Plant Cell 19:3347-3368(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Entry informationi

Entry nameiM2DH_PHANO
AccessioniPrimary (citable) accession number: Q0UEB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: September 5, 2006
Last modified: April 1, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.