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Q0UEB6

- M2DH_PHANO

UniProt

Q0UEB6 - M2DH_PHANO

Protein

Mannitol 2-dehydrogenase

Gene

SNOG_09898

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.By similarity

    Catalytic activityi

    D-mannitol + NAD+ = D-fructose + NADH.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi109 – 12012NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. mannitol 2-dehydrogenase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannitol 2-dehydrogenase (EC:1.1.1.67)
    Short name:
    M2DH
    Short name:
    MDH
    Gene namesi
    ORF Names:SNOG_09898
    OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
    Taxonomic identifieri321614 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
    ProteomesiUP000001055: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 568568Mannitol 2-dehydrogenasePRO_0000371547Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ0UEB6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mannitol dehydrogenase family.Curated

    Phylogenomic databases

    KOiK00045.
    OMAiWLHFVRR.
    OrthoDBiEOG7PCJRT.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view]
    PRINTSiPR00084. MTLDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0UEB6-1 [UniParc]FASTAAdd to Basket

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    MFSYLPRYPL RAASARALVR ATRPSYRSAL LRYQSSEAVG RTQEIVPGAY    50
    QIPPRDFSRQ HEEKLAPKNA ARAPRRIEPA TLKLNSKNLS QLQNVTVPTY 100
    QREGVKQGIV HVGVGGFHRA HLAAYVDTLL EQFNSQDWSI CGVDLQPFAA 150
    PMRDALGSQD NLYTMIECDT EGTSARVIGS ITDYLFAPDN CEAVIAKMAH 200
    PDTHIVSMTV TESGYYMNEN THELQIDHPD IAADLAGQQP PRTVFAYLYA 250
    ALARRHAAGL RPFTVMSCDN MQKNGDISRN MLLAFARQQN PEVADWIAEN 300
    GAFPNSMVDR ITPRTSDENK AQLAQEFGVE DSWPVVTEVF HQWVLEDKFA 350
    DGRPPFEKAG VQVVPNVHKV EEYELIKLRL LNASHSAMGY AGYLGGFTYI 400
    HEVIADPTFR KYIRNMMQEE VQPLLPRIPG VSVDDYCNTL LGRFSNPTLK 450
    DELPRICLGG SGKIPQFIMP SIAEQIQAGG PLRRLTLCAA AWFRYLRGIN 500
    EQGQAFKLDD PMAEELQAKA LESPFSVLEV KSLFGDDLRD DKRFVAELKN 550
    ALESLERDGA RATIAQYA 568
    Length:568
    Mass (Da):63,495
    Last modified:September 5, 2006 - v1
    Checksum:iBF3CECA2C4156C92
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH445339 Genomic DNA. Translation: EAT83163.1.
    RefSeqiXP_001800184.1. XM_001800132.1.

    Genome annotation databases

    EnsemblFungiiSNOT_09898; SNOT_09898; SNOG_09898.
    GeneIDi5977089.
    KEGGipno:SNOG_09898.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH445339 Genomic DNA. Translation: EAT83163.1 .
    RefSeqi XP_001800184.1. XM_001800132.1.

    3D structure databases

    ProteinModelPortali Q0UEB6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SNOT_09898 ; SNOT_09898 ; SNOG_09898 .
    GeneIDi 5977089.
    KEGGi pno:SNOG_09898.

    Phylogenomic databases

    KOi K00045.
    OMAi WLHFVRR.
    OrthoDBi EOG7PCJRT.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00084. MTLDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
      Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
      Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

    Entry informationi

    Entry nameiM2DH_PHANO
    AccessioniPrimary (citable) accession number: Q0UEB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3