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Q0UEB6 (M2DH_PHANO) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannitol 2-dehydrogenase

Short name=M2DH
Short name=MDH
EC=1.1.1.67
Gene names
ORF Names:SNOG_09898
OrganismPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) [Reference proteome]
Taxonomic identifier321614 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora

Protein attributes

Sequence length568 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway By similarity.

Catalytic activity

D-mannitol + NAD+ = D-fructose + NADH.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol 2-dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 568568Mannitol 2-dehydrogenase
PRO_0000371547

Regions

Nucleotide binding109 – 12012NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0UEB6 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: BF3CECA2C4156C92

FASTA56863,495
        10         20         30         40         50         60 
MFSYLPRYPL RAASARALVR ATRPSYRSAL LRYQSSEAVG RTQEIVPGAY QIPPRDFSRQ 

        70         80         90        100        110        120 
HEEKLAPKNA ARAPRRIEPA TLKLNSKNLS QLQNVTVPTY QREGVKQGIV HVGVGGFHRA 

       130        140        150        160        170        180 
HLAAYVDTLL EQFNSQDWSI CGVDLQPFAA PMRDALGSQD NLYTMIECDT EGTSARVIGS 

       190        200        210        220        230        240 
ITDYLFAPDN CEAVIAKMAH PDTHIVSMTV TESGYYMNEN THELQIDHPD IAADLAGQQP 

       250        260        270        280        290        300 
PRTVFAYLYA ALARRHAAGL RPFTVMSCDN MQKNGDISRN MLLAFARQQN PEVADWIAEN 

       310        320        330        340        350        360 
GAFPNSMVDR ITPRTSDENK AQLAQEFGVE DSWPVVTEVF HQWVLEDKFA DGRPPFEKAG 

       370        380        390        400        410        420 
VQVVPNVHKV EEYELIKLRL LNASHSAMGY AGYLGGFTYI HEVIADPTFR KYIRNMMQEE 

       430        440        450        460        470        480 
VQPLLPRIPG VSVDDYCNTL LGRFSNPTLK DELPRICLGG SGKIPQFIMP SIAEQIQAGG 

       490        500        510        520        530        540 
PLRRLTLCAA AWFRYLRGIN EQGQAFKLDD PMAEELQAKA LESPFSVLEV KSLFGDDLRD 

       550        560 
DKRFVAELKN ALESLERDGA RATIAQYA 

« Hide

References

[1]"Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH445339 Genomic DNA. Translation: EAT83163.1.
RefSeqXP_001800184.1. XM_001800132.1.

3D structure databases

ProteinModelPortalQ0UEB6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSNOT_09898; SNOT_09898; SNOG_09898.
GeneID5977089.
KEGGpno:SNOG_09898.

Phylogenomic databases

KOK00045.
OMAFEKVGVQ.
OrthoDBEOG7PCJRT.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
ProtoNetSearch...

Entry information

Entry nameM2DH_PHANO
AccessionPrimary (citable) accession number: Q0UEB6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: September 5, 2006
Last modified: November 13, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families