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Protein

DNA ligase 4

Gene

LIG4

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining.By similarity

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.PROSITE-ProRule annotation

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei324ATPBy similarity1
Active sitei326N6-AMP-lysine intermediatePROSITE-ProRule annotation1
Binding sitei331ATPBy similarity1
Binding sitei353ATPBy similarity1
Metal bindingi394Magnesium 1Sequence analysis1
Metal bindingi496Magnesium 2Sequence analysis1
Binding sitei501ATPBy similarity1
Binding sitei512ATPBy similarity1
Binding sitei518ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processDNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 4 (EC:6.5.1.1)
Alternative name(s):
DNA ligase IV
Polydeoxyribonucleotide synthase [ATP] 4
Gene namesi
Name:LIG4
ORF Names:SNOG_10525
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
Proteomesi
  • UP000001055 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002783851 – 990DNA ligase 4Add BLAST990

Interactioni

Protein-protein interaction databases

STRINGi13684.SNOT_10525

Structurei

3D structure databases

ProteinModelPortaliQ0UCI9
SMRiQ0UCI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini728 – 821BRCT 1PROSITE-ProRule annotationAdd BLAST94
Domaini900 – 989BRCT 2PROSITE-ProRule annotationAdd BLAST90

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiQ0UCI9
KOiK10777
OMAiHMCPSTK
OrthoDBiEOG092C18KW

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
3.40.50.10190, 2 hits
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR029710 LIG4
IPR012340 NA-bd_OB-fold
PANTHERiPTHR10459:SF7 PTHR10459:SF7, 1 hit
PfamiView protein in Pfam
PF16589 BRCT_2, 1 hit
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
SSF52113 SSF52113, 2 hits
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 2 hits
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q0UCI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDTEMPDA EAVRENTLMY GHDDELDEKF PTRPMNLHKS PPFHTLFTDL
60 70 80 90 100
FDPLMETQKK GRQPPGPRRK AGPHGHSNLS PHEAKRNIIE RFIASWRKTV
110 120 130 140 150
GNDFYPAMRL IIPDKDRDRA MYGLKEKAIA KVLIKLTKIS KDSDDAKQML
160 170 180 190 200
NWKLPGQLHK ASASTAGDFA GRCYQVLSSR QLNTKLGDMS IAEVNNALDK
210 220 230 240 250
LSQLGSEDEQ VKIFQRFNRR MNAEEMTWLI RIILRQMKIG ATEKTFLDIW
260 270 280 290 300
HPDAETLFNI SSNLRRVCWE LYDPKVRLEG EDTGLSLMQC FQPQLAAFQD
310 320 330 340 350
KGGSFEKIVA RLQANSDDDS FWIEEKLDGE RMQLHMIEDP EAPGGKLFGF
360 370 380 390 400
WSRKAKDYAY LYGKHLQGDE AGALTRFITD AFGKNVRNII LDGEMITWDM
410 420 430 440 450
DVDHIVGFGT LKTAAISEKE NKTDKSTGQR PLFRVFDCVY LNDKLLTPYT
460 470 480 490 500
LRDRRRALES AVKDVKRRLE IHPYIEAHSH TEIEPALRKV VAESSEGLVL
510 520 530 540 550
KNPRSMYRLN DRNADWMKVK PEYMSEFGES LDCIVVGGYF GSGHRGGAHS
560 570 580 590 600
SFLCALLLNK DAKPGDADYE KCWSFFKVGG GFSREDYAAI RGRTEGKWKD
610 620 630 640 650
WDPRRPPPII ELGGHEQNRQ HERPDQWIHP SDSVVLECKA ASVEGSDKFR
660 670 680 690 700
FNLTLRFPRF RMLRTDKRWD QALSREEFYE IKANVEYKRE EKEKEFEIEK
710 720 730 740 750
SRRKRTRTTK KPIVVAGSET ITTPYAGPQS KIFDGLSFYI MTEQLHPTKK
760 770 780 790 800
SKVDLEALVK ANGGRVVQRD SMEPNLVIVA DKRLIKVASL EKRDTNNIVK
810 820 830 840 850
PVWIQDTIQQ NEVDNGALPY LLPFEPNRHM FYLLGDNQLD YEANADDYGD
860 870 880 890 900
SYARDIADVE EMRKILGATD PPQKRTKFDR ESFLDQLEDH GDSLSHLKTY
910 920 930 940 950
MFSSTKVAFR TSDDPVWTLR AQLAGNYIRF GGGQITEDED EEGVTHTVVP
960 970 980 990
DGQTASVSRV ADLSRVVGVG WVQKCWDEST RLDEERYQWG
Length:990
Mass (Da):113,591
Last modified:September 5, 2006 - v1
Checksum:i8B9386A5E66CAA50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445341 Genomic DNA Translation: EAT81919.1
RefSeqiXP_001800794.1, XM_001800742.1

Genome annotation databases

EnsemblFungiiSNOT_10525; SNOT_10525; SNOG_10525
GeneIDi5977701
KEGGipno:SNOG_10525

Similar proteinsi

Entry informationi

Entry nameiDNLI4_PHANO
AccessioniPrimary (citable) accession number: Q0UCI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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