Q0U6G5 (AMPP3_PHANO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase PEPP
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	PEPP
ORF Names:	SNOG_12649

Organism

Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) [Reference proteome]

Taxonomic identifier

321614 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › dothideomyceta › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporineae › Phaeosphaeriaceae › Phaeosphaeria › Phaeosphaeria nodorum

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	Probable Xaa-Pro aminopeptidase PEPP		PRO_0000411884
Sites
	Metal binding	259	1	Manganese 2 By similarity
	Metal binding	270	1	Manganese 1 By similarity
	Metal binding	270	1	Manganese 2 By similarity
	Metal binding	393	1	Manganese 1 By similarity
	Metal binding	433	1	Manganese 1 By similarity
	Metal binding	433	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0U6G5 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 78C24DF928B245D3	FASTA	463	52,024
	10 20 30 40 50 60 MAIAENYDEV LKGKYPAKDH ARKVAKWIVD KGGDKKGTIY LEAQKQKLNE DNDGEAPFRQ 70 80 90 100 110 120 RRYFFYLSGC ELPDSYLTYD FPSDKLTLFI PPVEPEEVIW SGLPMSPEEA KAKYDIDDCK 130 140 150 160 170 180 TTKEVNPHLA SSSETAQSTI YAIPGQISDE TTFLSYQNKD LEQLKTAIEY CRVTKSDYEI 190 200 210 220 230 240 ALIRKANVIS TNAHINVMKA AAKAQNECEL EAVFLKSCVE RNAKNQAYHS IVAAGENGAT 250 260 270 280 290 300 LHYVHNAAPI KSQNLMLLDA GCEVDCYASD ITRTFPIKGT FTDESLAIYK IVLDMQKQCI 310 320 330 340 350 360 NALKAGVLWD SIHELAHKIA IKGLLELGIL KGDVEQIFKA RTSVAFFPHG LGHYLGMDTH 370 380 390 400 410 420 DTGGNANYAD KDRMFRYLRV RGTLPARSVI TVEPGIYFCR FIIEPYLKDD QQKQYIDEKV 430 440 450 460 LEKYWSVGGV RIEDNILVTE DGIENLTPTP KEIDEITSLV KSG

References

[1]

"Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum." Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P. Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH445347 Genomic DNA. Translation: EAT79947.1.
RefSeq	XP_001802870.1. XM_001802818.1.
3D structure databases
ProteinModelPortal	Q0U6G5.
ModBase	Search...
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SNOT_12649; SNOT_12649; SNOG_12649.
GeneID	5979781.
KEGG	pno:SNOG_12649.
Phylogenomic databases
KO	K14213.
OMA	MFRYLRV.
OrthoDB	EOG4J40RD.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP3_PHANO

Accession

Primary (citable) accession number: Q0U6G5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	September 5, 2006
Last modified:	March 6, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program