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Protein

Catalase-peroxidase

Gene

katG

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei89Transition state stabilizerUniRule annotation1
Active sitei93Proton acceptorUniRule annotation1
Metal bindingi281Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3449. PnoCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
ORF Names:SNOG_13840
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
Proteomesi
  • UP000001055 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003541091 – 751Catalase-peroxidaseAdd BLAST751

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki92 ↔ 240Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-266)UniRule annotation
Cross-linki240 ↔ 266Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-92)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ0U324.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ0U324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

InParanoidiQ0U324.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiEOG092C0YTX.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0U324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKGECPMRT ANVAGGGTKI KDWWPNELPV SVLRQHDPRQ NPLTSDFNYA
60 70 80 90 100
EEFKKLDYNA LKKDLTALMT DSQDWWPADF GHYGGLFVRM AWHSAGTYRV
110 120 130 140 150
TDGRGGGGDG QQRFAPLNAW PDNVSLDKAR RLLWPIKQKY GNKISWADLM
160 170 180 190 200
LLTGNVALES MGCETFGFAG GRPDTFQSDE SIYWGGEDTW LGNDVRYSNG
210 220 230 240 250
NKGVSGEGVV DGDQHKMDHK DIHSRDLEQP VAAAHMGLIY VNPEGPDGVP
260 270 280 290 300
DPIAAARDIR TTFHRMAMND EETAALIIGG HSFGKTHGAA PSENTGPDPN
310 320 330 340 350
SEDLSTQGFG WINKHGSGKG PDTITSGLEV TWTGTPTKWS NKYLEYLYKY
360 370 380 390 400
EWELEKSPAG ANQWVAKTED HIIPDAYDAN KKHKPRMLTT DMSMRMDPGF
410 420 430 440 450
EKITRRWLDH PQELHDAFIR AWFKLLHRDM GPRSRWVGPE IPKEVLLWED
460 470 480 490 500
PVPEVDHALV EESDISALKK QILEAGIEPS KLIRTAWASA ASYRGSDKRG
510 520 530 540 550
GANGARIRLA PQKDWEVNNP KELAEVLKAL EGVQSKFNGS ASGGKKISLA
560 570 580 590 600
DLIVLAGTAA VEKAAGVSVP FTPGRTDATE EQTDAKSFEH LEPATDPFRN
610 620 630 640 650
YGKSSDRART EQLDLDKASL LRLTAPELTV LVGGMRALNA NWDSSSHGIF
660 670 680 690 700
TKRPGQLTND FFVNLLDINT EWKAADSSKL PELYEGFDRK SGQKKWTGTR
710 720 730 740 750
HDLVYGSHPE LRAIAEVYAQ PDNSDKFVKD FVKAWDKVMS NDRFDLKAKS

S
Length:751
Mass (Da):83,498
Last modified:September 5, 2006 - v1
Checksum:iFC5E1BFA5C89B85B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445352 Genomic DNA. Translation: EAT78864.1.
RefSeqiXP_001804042.1. XM_001803990.1.

Genome annotation databases

EnsemblFungiiSNOT_13840; SNOT_13840; SNOG_13840.
GeneIDi5980964.
KEGGipno:SNOG_13840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445352 Genomic DNA. Translation: EAT78864.1.
RefSeqiXP_001804042.1. XM_001803990.1.

3D structure databases

ProteinModelPortaliQ0U324.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei3449. PnoCP01.

Proteomic databases

PRIDEiQ0U324.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSNOT_13840; SNOT_13840; SNOG_13840.
GeneIDi5980964.
KEGGipno:SNOG_13840.

Phylogenomic databases

InParanoidiQ0U324.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiEOG092C0YTX.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_PHANO
AccessioniPrimary (citable) accession number: Q0U324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: September 5, 2006
Last modified: October 5, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.