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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi570Zinc; catalyticPROSITE-ProRule annotation1
Active sitei571PROSITE-ProRule annotation1
Metal bindingi574Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi577Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:SNOG_15771
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
Proteomesi
  • UP000001055 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000033859130 – 790Mitochondrial intermediate peptidaseAdd BLAST761

Structurei

3D structure databases

ProteinModelPortaliQ0TXL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiQ0TXL7.
KOiK01410.
OrthoDBiEOG092C0JU2.

Family and domain databases

CDDicd06457. M3A_MIP. 1 hit.
Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR033851. M3A_MIP.
IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PANTHERiPTHR11804:SF5. PTHR11804:SF5. 2 hits.
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0TXL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKRLARNNS SPWICSRCLQ QSQRQRRFNS TFAATATARD HAPSALYGLS
60 70 80 90 100
ASGKTDDDAL RKVFDNASFW ESFKRGTSNK KPSGIIGNKY LTHPDGFIDF
110 120 130 140 150
VTVTIQRCNG VVEKVSRAET IEDFKYMVKD LDKLSDLLCR VIDLADFVRS
160 170 180 190 200
THPNRQFQIM AVKAYHTVFQ YMNQLNTTPV LYDQLKKASD IPEVFESWTE
210 220 230 240 250
EERIVARILM EDFARFGIGL DDATRQKLVD LSGEIAEVGS QFVEGMSPET
260 270 280 290 300
PTLKFESKRL KGLDPNLAKA LTKWGETRIS TMHHEAQAVL RFVDDAEVRR
310 320 330 340 350
ETYSAVRTAG SSTIARLEKM LKLRAELAQL SGYETFSHMT LENKMAKTPE
360 370 380 390 400
AVNTFLKALY EDSRPSVLAD LHELMELKRG DAHQDNFPNR MNAWDKFYYT
410 420 430 440 450
QKMLSTMEGA YKQRTADSLS AYFSVGTVLQ GISRLFDRLY GVRLVPQETQ
460 470 480 490 500
PGEVWEDGVR RLDVISDTEG HIAVLYCDLF SRPGKTPNPA HFTLRCSREI
510 520 530 540 550
LPAELEEMQH MPHRFSSPIE AATDGMSVSY NASRNSYFQL PTIALICDFS
560 570 580 590 600
KPSSPRPTLL NIHDVRTLFH EMGHALHSIL GRTALQNVSG TRCATDIAEL
610 620 630 640 650
PSVLMEHFAF DPSVLALYAR HWDTNAPLPL ALLENRLAID NRNGYSELES
660 670 680 690 700
QILLAMLDQA YHSNLPLDPA FNSTSVYHNT YTRFASVPEP AGTRWQGFFG
710 720 730 740 750
HLFGYGATYY SYLFDRAIAS RIWKGVFNEG RDGGSLDREK GELYKNEVLR
760 770 780 790
WGGGRDGWVC LAGVLRDGKV GEGGEGAMRE VGKWGIDAGK
Length:790
Mass (Da):89,067
Last modified:February 5, 2008 - v2
Checksum:i3E8AFBC2E8963A45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445364 Genomic DNA. Translation: EAT76866.2.
RefSeqiXP_001805910.1. XM_001805858.1.

Genome annotation databases

EnsemblFungiiSNOT_15771; SNOT_15771; SNOG_15771.
GeneIDi5982840.
KEGGipno:SNOG_15771.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445364 Genomic DNA. Translation: EAT76866.2.
RefSeqiXP_001805910.1. XM_001805858.1.

3D structure databases

ProteinModelPortaliQ0TXL7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM03.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSNOT_15771; SNOT_15771; SNOG_15771.
GeneIDi5982840.
KEGGipno:SNOG_15771.

Phylogenomic databases

InParanoidiQ0TXL7.
KOiK01410.
OrthoDBiEOG092C0JU2.

Family and domain databases

CDDicd06457. M3A_MIP. 1 hit.
Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR033851. M3A_MIP.
IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PANTHERiPTHR11804:SF5. PTHR11804:SF5. 2 hits.
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPMIP_PHANO
AccessioniPrimary (citable) accession number: Q0TXL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 5, 2008
Last modified: November 30, 2016
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.