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Q0TXL7

- PMIP_PHANO

UniProt

Q0TXL7 - PMIP_PHANO

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi570 – 5701Zinc; catalyticPROSITE-ProRule annotation
    Active sitei571 – 5711PROSITE-ProRule annotation
    Metal bindingi574 – 5741Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi577 – 5771Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    ORF Names:SNOG_15771
    OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
    Taxonomic identifieri321614 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
    ProteomesiUP000001055: Unassembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2929MitochondrionSequence AnalysisAdd
    BLAST
    Chaini30 – 790761Mitochondrial intermediate peptidasePRO_0000338591Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ0TXL7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    KOiK01410.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0TXL7-1 [UniParc]FASTAAdd to Basket

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    MLKRLARNNS SPWICSRCLQ QSQRQRRFNS TFAATATARD HAPSALYGLS    50
    ASGKTDDDAL RKVFDNASFW ESFKRGTSNK KPSGIIGNKY LTHPDGFIDF 100
    VTVTIQRCNG VVEKVSRAET IEDFKYMVKD LDKLSDLLCR VIDLADFVRS 150
    THPNRQFQIM AVKAYHTVFQ YMNQLNTTPV LYDQLKKASD IPEVFESWTE 200
    EERIVARILM EDFARFGIGL DDATRQKLVD LSGEIAEVGS QFVEGMSPET 250
    PTLKFESKRL KGLDPNLAKA LTKWGETRIS TMHHEAQAVL RFVDDAEVRR 300
    ETYSAVRTAG SSTIARLEKM LKLRAELAQL SGYETFSHMT LENKMAKTPE 350
    AVNTFLKALY EDSRPSVLAD LHELMELKRG DAHQDNFPNR MNAWDKFYYT 400
    QKMLSTMEGA YKQRTADSLS AYFSVGTVLQ GISRLFDRLY GVRLVPQETQ 450
    PGEVWEDGVR RLDVISDTEG HIAVLYCDLF SRPGKTPNPA HFTLRCSREI 500
    LPAELEEMQH MPHRFSSPIE AATDGMSVSY NASRNSYFQL PTIALICDFS 550
    KPSSPRPTLL NIHDVRTLFH EMGHALHSIL GRTALQNVSG TRCATDIAEL 600
    PSVLMEHFAF DPSVLALYAR HWDTNAPLPL ALLENRLAID NRNGYSELES 650
    QILLAMLDQA YHSNLPLDPA FNSTSVYHNT YTRFASVPEP AGTRWQGFFG 700
    HLFGYGATYY SYLFDRAIAS RIWKGVFNEG RDGGSLDREK GELYKNEVLR 750
    WGGGRDGWVC LAGVLRDGKV GEGGEGAMRE VGKWGIDAGK 790
    Length:790
    Mass (Da):89,067
    Last modified:February 5, 2008 - v2
    Checksum:i3E8AFBC2E8963A45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH445364 Genomic DNA. Translation: EAT76866.2.
    RefSeqiXP_001805910.1. XM_001805858.1.

    Genome annotation databases

    EnsemblFungiiSNOT_15771; SNOT_15771; SNOG_15771.
    GeneIDi5982840.
    KEGGipno:SNOG_15771.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH445364 Genomic DNA. Translation: EAT76866.2 .
    RefSeqi XP_001805910.1. XM_001805858.1.

    3D structure databases

    ProteinModelPortali Q0TXL7.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SNOT_15771 ; SNOT_15771 ; SNOG_15771 .
    GeneIDi 5982840.
    KEGGi pno:SNOG_15771.

    Phylogenomic databases

    KOi K01410.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
      Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
      Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

    Entry informationi

    Entry nameiPMIP_PHANO
    AccessioniPrimary (citable) accession number: Q0TXL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 52 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3