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Q0TXL7

- PMIP_PHANO

UniProt

Q0TXL7 - PMIP_PHANO

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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi570 – 5701Zinc; catalyticPROSITE-ProRule annotation
Active sitei571 – 5711PROSITE-ProRule annotation
Metal bindingi574 – 5741Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi577 – 5771Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:SNOG_15771
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
ProteomesiUP000001055: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929MitochondrionSequence AnalysisAdd
BLAST
Chaini30 – 790761Mitochondrial intermediate peptidasePRO_0000338591Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ0TXL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiQ0TXL7.
KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0TXL7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKRLARNNS SPWICSRCLQ QSQRQRRFNS TFAATATARD HAPSALYGLS
60 70 80 90 100
ASGKTDDDAL RKVFDNASFW ESFKRGTSNK KPSGIIGNKY LTHPDGFIDF
110 120 130 140 150
VTVTIQRCNG VVEKVSRAET IEDFKYMVKD LDKLSDLLCR VIDLADFVRS
160 170 180 190 200
THPNRQFQIM AVKAYHTVFQ YMNQLNTTPV LYDQLKKASD IPEVFESWTE
210 220 230 240 250
EERIVARILM EDFARFGIGL DDATRQKLVD LSGEIAEVGS QFVEGMSPET
260 270 280 290 300
PTLKFESKRL KGLDPNLAKA LTKWGETRIS TMHHEAQAVL RFVDDAEVRR
310 320 330 340 350
ETYSAVRTAG SSTIARLEKM LKLRAELAQL SGYETFSHMT LENKMAKTPE
360 370 380 390 400
AVNTFLKALY EDSRPSVLAD LHELMELKRG DAHQDNFPNR MNAWDKFYYT
410 420 430 440 450
QKMLSTMEGA YKQRTADSLS AYFSVGTVLQ GISRLFDRLY GVRLVPQETQ
460 470 480 490 500
PGEVWEDGVR RLDVISDTEG HIAVLYCDLF SRPGKTPNPA HFTLRCSREI
510 520 530 540 550
LPAELEEMQH MPHRFSSPIE AATDGMSVSY NASRNSYFQL PTIALICDFS
560 570 580 590 600
KPSSPRPTLL NIHDVRTLFH EMGHALHSIL GRTALQNVSG TRCATDIAEL
610 620 630 640 650
PSVLMEHFAF DPSVLALYAR HWDTNAPLPL ALLENRLAID NRNGYSELES
660 670 680 690 700
QILLAMLDQA YHSNLPLDPA FNSTSVYHNT YTRFASVPEP AGTRWQGFFG
710 720 730 740 750
HLFGYGATYY SYLFDRAIAS RIWKGVFNEG RDGGSLDREK GELYKNEVLR
760 770 780 790
WGGGRDGWVC LAGVLRDGKV GEGGEGAMRE VGKWGIDAGK
Length:790
Mass (Da):89,067
Last modified:February 5, 2008 - v2
Checksum:i3E8AFBC2E8963A45
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH445364 Genomic DNA. Translation: EAT76866.2.
RefSeqiXP_001805910.1. XM_001805858.1.

Genome annotation databases

EnsemblFungiiSNOT_15771; SNOT_15771; SNOG_15771.
GeneIDi5982840.
KEGGipno:SNOG_15771.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH445364 Genomic DNA. Translation: EAT76866.2 .
RefSeqi XP_001805910.1. XM_001805858.1.

3D structure databases

ProteinModelPortali Q0TXL7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SNOT_15771 ; SNOT_15771 ; SNOG_15771 .
GeneIDi 5982840.
KEGGi pno:SNOG_15771.

Phylogenomic databases

InParanoidi Q0TXL7.
KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
    Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
    Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Entry informationi

Entry nameiPMIP_PHANO
AccessioniPrimary (citable) accession number: Q0TXL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3