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Q0TXL7 (PMIP_PHANO) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial intermediate peptidase

Short name=MIP
EC=3.4.24.59
Alternative name(s):
Octapeptidyl aminopeptidase
Gene names
Name:OCT1
ORF Names:SNOG_15771
OrganismPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) [Reference proteome]
Taxonomic identifier321614 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora

Protein attributes

Sequence length790 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activity

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactor

Binds 1 zinc ion By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the peptidase M3 family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
Metalloprotease
Protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

metalloendopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2929Mitochondrion Potential
Chain30 – 790761Mitochondrial intermediate peptidase
PRO_0000338591

Sites

Active site5711 By similarity
Metal binding5701Zinc; catalytic By similarity
Metal binding5741Zinc; catalytic By similarity
Metal binding5771Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0TXL7 [UniParc].

Last modified February 5, 2008. Version 2.
Checksum: 3E8AFBC2E8963A45

FASTA79089,067
        10         20         30         40         50         60 
MLKRLARNNS SPWICSRCLQ QSQRQRRFNS TFAATATARD HAPSALYGLS ASGKTDDDAL 

        70         80         90        100        110        120 
RKVFDNASFW ESFKRGTSNK KPSGIIGNKY LTHPDGFIDF VTVTIQRCNG VVEKVSRAET 

       130        140        150        160        170        180 
IEDFKYMVKD LDKLSDLLCR VIDLADFVRS THPNRQFQIM AVKAYHTVFQ YMNQLNTTPV 

       190        200        210        220        230        240 
LYDQLKKASD IPEVFESWTE EERIVARILM EDFARFGIGL DDATRQKLVD LSGEIAEVGS 

       250        260        270        280        290        300 
QFVEGMSPET PTLKFESKRL KGLDPNLAKA LTKWGETRIS TMHHEAQAVL RFVDDAEVRR 

       310        320        330        340        350        360 
ETYSAVRTAG SSTIARLEKM LKLRAELAQL SGYETFSHMT LENKMAKTPE AVNTFLKALY 

       370        380        390        400        410        420 
EDSRPSVLAD LHELMELKRG DAHQDNFPNR MNAWDKFYYT QKMLSTMEGA YKQRTADSLS 

       430        440        450        460        470        480 
AYFSVGTVLQ GISRLFDRLY GVRLVPQETQ PGEVWEDGVR RLDVISDTEG HIAVLYCDLF 

       490        500        510        520        530        540 
SRPGKTPNPA HFTLRCSREI LPAELEEMQH MPHRFSSPIE AATDGMSVSY NASRNSYFQL 

       550        560        570        580        590        600 
PTIALICDFS KPSSPRPTLL NIHDVRTLFH EMGHALHSIL GRTALQNVSG TRCATDIAEL 

       610        620        630        640        650        660 
PSVLMEHFAF DPSVLALYAR HWDTNAPLPL ALLENRLAID NRNGYSELES QILLAMLDQA 

       670        680        690        700        710        720 
YHSNLPLDPA FNSTSVYHNT YTRFASVPEP AGTRWQGFFG HLFGYGATYY SYLFDRAIAS 

       730        740        750        760        770        780 
RIWKGVFNEG RDGGSLDREK GELYKNEVLR WGGGRDGWVC LAGVLRDGKV GEGGEGAMRE 

       790 
VGKWGIDAGK 

« Hide

References

[1]"Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH445364 Genomic DNA. Translation: EAT76866.2.
RefSeqXP_001805910.1. XM_001805858.1.

3D structure databases

ProteinModelPortalQ0TXL7.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSM03.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSNOT_15771; SNOT_15771; SNOG_15771.
GeneID5982840.
KEGGpno:SNOG_15771.

Phylogenomic databases

KOK01410.
OrthoDBEOG71GB4R.

Family and domain databases

Gene3D1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePMIP_PHANO
AccessionPrimary (citable) accession number: Q0TXL7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 5, 2008
Last modified: November 13, 2013
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries