Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei84ATPPROSITE-ProRule annotation1
Active sitei185Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi60 – 68ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
ORF Names:SNOG_16136
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
Proteomesi
  • UP000001055 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129491 – 443Serine/threonine-protein kinase SSN3Add BLAST443

Proteomic databases

PRIDEiQ0TWJ7

Interactioni

Subunit structurei

Component of the srb8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi13684.SNOT_16136

Structurei

3D structure databases

ProteinModelPortaliQ0TWJ7
SMRiQ0TWJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 384Protein kinasePROSITE-ProRule annotationAdd BLAST331

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ0TWJ7
KOiK02208
OMAiKSIYMVF
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q0TWJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKRGREMN PPSADPPSAT PVARANLPGS VAAAFHGRPC SQGTTTLKRV
60 70 80 90 100
NERYKIVGFI SSGTYGRVYK AEGKNGRTGE FAIKKFKPDK EGELQYSGIS
110 120 130 140 150
QSAIREMALC TELAHPNVVH TVEIILEEKC IFIVFEYAEH DLLQIIHHHN
160 170 180 190 200
QPQRQAIPAR TIKSILYQLL QGLVYLHRNW VMHRDLKPAN IMVTSAGKVK
210 220 230 240 250
IGDLGLARLF YKPLQSLFSG DKVVVTIWYR APELLLGSRH YTPAVDLWAV
260 270 280 290 300
GCIFAELLSL RPIFKGEEAK MDSKKTVPFQ RNQMQKIVEI MGMPSKDRWP
310 320 330 340 350
LLTAMPEYPQ LSSLIAGNAA RFARPQGGDG LDRWYNQTLI NNQYPAGPGP
360 370 380 390 400
ETPGAEGLAL LKQLLEYDPQ KRLTAEKALE HRYFTEHGKP SDNCFEDSKI
410 420 430 440
KYPVRRVSQE DNDIRTSSLP GTKRSGLPDD SLMGRPAKRL KEG
Length:443
Mass (Da):49,756
Last modified:September 5, 2006 - v1
Checksum:i5FE8CBD16BF4247B
GO

Sequence cautioni

The sequence EAT76508 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445367 Genomic DNA Translation: EAT76508.2 Sequence problems.
RefSeqiXP_001806263.1, XM_001806211.1

Genome annotation databases

GeneIDi5983193
KEGGipno:SNOG_16136

Similar proteinsi

Entry informationi

Entry nameiSSN3_PHANO
AccessioniPrimary (citable) accession number: Q0TWJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health