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Q0TWJ7 (SSN3_PHANO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase SSN3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:SSN3
Synonyms:CDK8
ORF Names:SNOG_16136
OrganismPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) [Reference proteome]
Taxonomic identifier321614 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the srb8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence EAT76508.2 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Serine/threonine-protein kinase SSN3
PRO_0000312949

Regions

Domain54 – 384331Protein kinase
Nucleotide binding60 – 689ATP By similarity

Sites

Active site1851Proton acceptor By similarity
Binding site841ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0TWJ7 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 5FE8CBD16BF4247B

FASTA44349,756
        10         20         30         40         50         60 
MERKRGREMN PPSADPPSAT PVARANLPGS VAAAFHGRPC SQGTTTLKRV NERYKIVGFI 

        70         80         90        100        110        120 
SSGTYGRVYK AEGKNGRTGE FAIKKFKPDK EGELQYSGIS QSAIREMALC TELAHPNVVH 

       130        140        150        160        170        180 
TVEIILEEKC IFIVFEYAEH DLLQIIHHHN QPQRQAIPAR TIKSILYQLL QGLVYLHRNW 

       190        200        210        220        230        240 
VMHRDLKPAN IMVTSAGKVK IGDLGLARLF YKPLQSLFSG DKVVVTIWYR APELLLGSRH 

       250        260        270        280        290        300 
YTPAVDLWAV GCIFAELLSL RPIFKGEEAK MDSKKTVPFQ RNQMQKIVEI MGMPSKDRWP 

       310        320        330        340        350        360 
LLTAMPEYPQ LSSLIAGNAA RFARPQGGDG LDRWYNQTLI NNQYPAGPGP ETPGAEGLAL 

       370        380        390        400        410        420 
LKQLLEYDPQ KRLTAEKALE HRYFTEHGKP SDNCFEDSKI KYPVRRVSQE DNDIRTSSLP 

       430        440 
GTKRSGLPDD SLMGRPAKRL KEG 

« Hide

References

[1]"Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum."
Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L., Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E., Torriani S.F.F., McDonald B.A., Oliver R.P.
Plant Cell 19:3347-3368(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SN15 / ATCC MYA-4574 / FGSC 10173.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH445367 Genomic DNA. Translation: EAT76508.2. Sequence problems.
RefSeqXP_001806263.1. XM_001806211.1.

3D structure databases

ProteinModelPortalQ0TWJ7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5983193.
KEGGpno:SNOG_16136.

Phylogenomic databases

KOK02208.
OMAVSQDDND.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_PHANO
AccessionPrimary (citable) accession number: Q0TWJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families