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Protein

Beta-galactosidase Pbg

Gene

pbg

Organism
Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei118SubstrateBy similarity1
Metal bindingi122ZincBy similarity1
Binding sitei156SubstrateBy similarity1
Active sitei157Proton donorBy similarity1
Metal bindingi162ZincBy similarity1
Metal bindingi164ZincBy similarity1
Metal bindingi167ZincBy similarity1
Active sitei318NucleophileBy similarity1
Binding sitei326SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

CAZyiGH42. Glycoside Hydrolase Family 42.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase Pbg (EC:3.2.1.23)
Short name:
Beta-galBy similarity
Gene namesi
Name:pbgImported
Ordered Locus Names:CPF_0160
OrganismiClostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001823 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004076881 – 689Beta-galactosidase PbgAdd BLAST689

Proteomic databases

PRIDEiQ0TUR6.

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_0160.

Structurei

3D structure databases

ProteinModelPortaliQ0TUR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni366 – 369Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the glycosyl hydrolase 42 family.Sequence analysis

Phylogenomic databases

eggNOGiENOG4105C4C. Bacteria.
COG1874. LUCA.
HOGENOMiHOG000117811.
KOiK12308.
OMAiRFVTHQT.
OrthoDBiPOG091H0719.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR013739. Beta_galactosidase_C.
IPR013738. Beta_galactosidase_Trimer.
IPR029062. Class_I_gatase-like.
IPR003476. Glyco_hydro_42.
IPR013529. Glyco_hydro_42_N.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02449. Glyco_hydro_42. 1 hit.
PF08533. Glyco_hydro_42C. 1 hit.
PF08532. Glyco_hydro_42M. 1 hit.
[Graphical view]
PIRSFiPIRSF001084. B-galactosidase. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52317. SSF52317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0TUR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNYGPISSK VTKMLHGADY NPEQWIDMPN IWGEDVRLMK LSHTNVVAVG
60 70 80 90 100
IFSWTMLEPE EGKFNFEWLD EIMDLMHKNG NYVILATPSG AKPIWMAHKY
110 120 130 140 150
PETLRVAQNR VRNLYGERHN HCYTSPIYRE KIAIIDRLLA ERYKDHPALI
160 170 180 190 200
LWHISNEFEG QCYCPLCEEA FRDFLREKYD NDINKLNKAW WTKFWSHTYA
210 220 230 240 250
SFDEIEAPAP HGEPALHGLN LDWMRFVTHQ TLDYYKHERS ILKEITPDIP
260 270 280 290 300
VTTNFHDYIS LFRGIDYWKF APYLDVVSWD NYPYWHGERT DDHEGSRIGF
310 320 330 340 350
VHDLNRAILN GKPFMMMESS PSSTNWQPVA KLRRPGMHVL SSLQAVAHGS
360 370 380 390 400
DTVQYFQWRK SRGSSEKFHG AVVDHCGHEN TRVFRDVTKV GEILSKLDDV
410 420 430 440 450
IGTSVEPQVA VIYDWENYWA INDAQGPRIE QKDYFETCQK HYKAFWDMSI
460 470 480 490 500
PTDVINMDCD FSKYKVVVAP MLYMVRPGVG ERLEEFVKNG GTLVTTYWSG
510 520 530 540 550
IVDENDLCFL GGFPGPLKKV TGIWAEELDA LYDEDVNYVS VEEGNSLGMK
560 570 580 590 600
GEYEARIFCD LIHSEGAEVL ATYKTDFYKG MPALTCNNFG EGQAYYIAFR
610 620 630 640 650
NNDEFLSDFY SSLAKKLTLK RAIEIDLPKG INAQVRMDEK NEFVFFMNFS
660 670 680
SEEKTIDIKD LDLTDMVTGE KVAKEMEIEP YGVRIVRRK
Length:689
Mass (Da):79,981
Last modified:September 5, 2006 - v1
Checksum:i6034BFC444243857
GO

Sequence cautioni

The sequence BAA08485 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49537 Genomic DNA. Translation: BAA08485.1. Different initiation.
CP000246 Genomic DNA. Translation: ABG83924.1.
RefSeqiWP_049752156.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG83924; ABG83924; CPF_0160.
KEGGicpf:CPF_0160.
PATRICi19482617. VBICloPer106549_0147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49537 Genomic DNA. Translation: BAA08485.1. Different initiation.
CP000246 Genomic DNA. Translation: ABG83924.1.
RefSeqiWP_049752156.1. NC_008261.1.

3D structure databases

ProteinModelPortaliQ0TUR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi195103.CPF_0160.

Protein family/group databases

CAZyiGH42. Glycoside Hydrolase Family 42.

Proteomic databases

PRIDEiQ0TUR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG83924; ABG83924; CPF_0160.
KEGGicpf:CPF_0160.
PATRICi19482617. VBICloPer106549_0147.

Phylogenomic databases

eggNOGiENOG4105C4C. Bacteria.
COG1874. LUCA.
HOGENOMiHOG000117811.
KOiK12308.
OMAiRFVTHQT.
OrthoDBiPOG091H0719.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR013739. Beta_galactosidase_C.
IPR013738. Beta_galactosidase_Trimer.
IPR029062. Class_I_gatase-like.
IPR003476. Glyco_hydro_42.
IPR013529. Glyco_hydro_42_N.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02449. Glyco_hydro_42. 1 hit.
PF08533. Glyco_hydro_42C. 1 hit.
PF08532. Glyco_hydro_42M. 1 hit.
[Graphical view]
PIRSFiPIRSF001084. B-galactosidase. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52317. SSF52317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBGAL_CLOP1
AccessioniPrimary (citable) accession number: Q0TUR6
Secondary accession number(s): Q46253, Q59312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.