Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).UniRule annotation

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 1 Fe cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54IronUniRule annotation1
Metal bindingi58IronUniRule annotation1
Metal bindingi121IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAutoinducer synthesis, Quorum sensing
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciCPER195103:G1G5R-175-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyaseUniRule annotation (EC:4.4.1.21UniRule annotation)
Alternative name(s):
AI-2 synthesis proteinUniRule annotation
Autoinducer-2 production protein LuxSUniRule annotation
Gene namesi
Name:luxSUniRule annotation
Ordered Locus Names:CPF_0171
OrganismiClostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001823 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002979911 – 151S-ribosylhomocysteine lyaseAdd BLAST151

Proteomic databases

PRIDEiQ0TUQ5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi195103.CPF_0171

Structurei

3D structure databases

ProteinModelPortaliQ0TUQ5
SMRiQ0TUQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106762 Bacteria
COG1854 LUCA
HOGENOMiHOG000040372
KOiK07173
OMAiAIHTLEH
OrthoDBiPOG091H0623

Family and domain databases

Gene3Di3.30.1360.80, 1 hit
HAMAPiMF_00091 LuxS, 1 hit
InterProiView protein in InterPro
IPR037005 LuxS_sf
IPR011249 Metalloenz_LuxS/M16
IPR003815 S-ribosylhomocysteinase
PANTHERiPTHR35799 PTHR35799, 1 hit
PfamiView protein in Pfam
PF02664 LuxS, 1 hit
PIRSFiPIRSF006160 AI2, 1 hit
PRINTSiPR01487 LUXSPROTEIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013172 S-ribosylhomocysteinase, 1 hit
SUPFAMiSSF63411 SSF63411, 1 hit

Sequencei

Sequence statusi: Complete.

Q0TUQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKVESFELD HTKVKAPYVR KAGIKIGPKG DIVSKFDLRF VQPNKELLSD
60 70 80 90 100
KGMHTLEHFL AGFMREKLDD VIDISPMGCK TGFYLTSFGD INVKDIIEAL
110 120 130 140 150
EYSLSKVLEQ EEIPAANELQ CGSAKLHSLE LAKSHAKQVL ENGISDKFYV

E
Length:151
Mass (Da):16,931
Last modified:September 5, 2006 - v1
Checksum:iF956488CE1F75F6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000246 Genomic DNA Translation: ABG83205.1
RefSeqiWP_011590095.1, NC_008261.1

Genome annotation databases

EnsemblBacteriaiABG83205; ABG83205; CPF_0171
GeneIDi29572707
KEGGicpf:CPF_0171

Similar proteinsi

Entry informationi

Entry nameiLUXS_CLOP1
AccessioniPrimary (citable) accession number: Q0TUQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health