ID   NANE_CLOP1              Reviewed;         221 AA.
AC   Q0TUP9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Putative N-acetylmannosamine-6-phosphate 2-epimerase;
DE            EC=5.1.3.9;
DE   AltName: Full=ManNAc-6-P epimerase;
GN   Name=nanE; OrderedLocusNames=CPF_0177;
OS   Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16825665; DOI=10.1101/gr.5238106;
RA   Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R.,
RA   DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C.,
RA   Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J.,
RA   Sullivan S.A., Khouri H., Dimitrov G.I., Watkins K.L., Mulligan S.,
RA   Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H.,
RA   Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I.,
RA   Melville S.B., Paulsen I.T.;
RT   "Skewed genomic variability in strains of the toxigenic bacterial
RT   pathogen, Clostridium perfringens.";
RL   Genome Res. 16:1031-1040(2006).
CC   -!- FUNCTION: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to
CC       N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (Potential).
CC   -!- CATALYTIC ACTIVITY: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-
CC       mannosamine 6-phosphate.
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminic acid
CC       degradation; D-fructose 6-phosphate from N-acetylneuraminic acid:
CC       step 3/5.
CC   -!- SIMILARITY: Belongs to the nanE family.
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DR   EMBL; CP000246; ABG84369.1; -; Genomic_DNA.
DR   RefSeq; YP_694641.1; -.
DR   GeneID; 4201411; -.
DR   GenomeReviews; CP000246_GR; CPF_0177.
DR   KEGG; cpf:CPF_0177; -.
DR   TIGR; CPF_0177; -.
DR   HOGENOM; Q0TUP9; -.
DR   OMA; Q0TUP9; YNTPELA.
DR   GO; GO:0047465; F:N-acylglucosamine-6-phosphate 2-epimerase a...; IEA:EC.
DR   GO; GO:0006051; P:N-acetylmannosamine metabolic process; IEA:HAMAP.
DR   HAMAP; MF_01235; -; 1.
DR   InterPro; IPR007260; NanE.
DR   Pfam; PF04131; NanE; 1.
DR   ProDom; PD002376; K_bP_aldolase; 1.
DR   ProDom; PD149806; TMP_synthase; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Isomerase.
FT   CHAIN         1    221       Putative N-acetylmannosamine-6-phosphate
FT                                2-epimerase.
FT                                /FTId=PRO_0000301468.
SQ   SEQUENCE   221 AA;  24153 MW;  40147518E31660B4 CRC64;
     MLDVVKGNLI VSCQALSDEP LHSSFIMGRM AIAAKQGGAA AIRAQGVNDI NEIKEVTKLP
     IIGIIKRNYD DSEIYITPTM KEVDELLKTD CEMIALDATK RKRPNGENVK DLVDAIHAKG
     RLAMADISTL EEGIEAEKLG FDCVSTTLSG YTPYSKQSNS VDFELLEELV KTVKIPVICE
     GRINTPEELK KALDLGAYSA VVGGAITRPQ QITKRFTDIL K
//