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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciCPER195103:G1G5R-265-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:CPF_0258
OrganismiClostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001823 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000098811 – 225Uracil-DNA glycosylaseAdd BLAST225

Proteomic databases

PRIDEiQ0TUH0

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_0258

Structurei

3D structure databases

ProteinModelPortaliQ0TUH0
SMRiQ0TUH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
HOGENOMiHOG000229528
KOiK03648
OMAiQANGLCF
OrthoDBiPOG091H03VL

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q0TUH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEFNNDWD DLLKDEFEKE YYLNLRKFLI NEYKTQKIHP SMYDIFNALK
60 70 80 90 100
FTPYKDVKVV ILGQDPYHGP NQAHGFSFSV KPGVQTPPSL RNMFKELNSD
110 120 130 140 150
LGCYIPNNGF LESWAKQGIL LLNTVLTVRE GQANSHKGKG WEIFTDRVIE
160 170 180 190 200
LLNKREEPIV FILWGRNAIS KEALITNSIH KIIKSVHPSP LSATRGFFGS
210 220
KPFSKTNDFL VSINKEPIDW QIPNI
Length:225
Mass (Da):25,874
Last modified:September 5, 2006 - v1
Checksum:i9A6ED7FE56A908C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000246 Genomic DNA Translation: ABG82389.1
RefSeqiWP_004458079.1, NC_008261.1

Genome annotation databases

EnsemblBacteriaiABG82389; ABG82389; CPF_0258
GeneIDi29572617
KEGGicpf:CPF_0258

Similar proteinsi

Entry informationi

Entry nameiUNG_CLOP1
AccessioniPrimary (citable) accession number: Q0TUH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health