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Q0TTQ4

- Q0TTQ4_CLOP1

UniProt

Q0TTQ4 - Q0TTQ4_CLOP1

Protein
Submitted name:

Sialidase

Gene

nanJ

Organism
Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi225 – 2251Calcium 1Imported
    Metal bindingi226 – 2261Calcium 1; via carbonyl oxygenImported
    Metal bindingi281 – 2811Calcium 1; via carbonyl oxygenImported
    Metal bindingi330 – 3301Calcium 2Imported
    Metal bindingi331 – 3311Calcium 2; via carbonyl oxygenImported
    Metal bindingi337 – 3371Calcium 2Imported

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. exo-alpha-sialidase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cell adhesion Source: InterPro

    Keywords - Ligandi

    CalciumImported, Metal-bindingImported

    Enzyme and pathway databases

    BioCyciCPER195103:GHAW-547-MONOMER.

    Protein family/group databases

    CAZyiCBM32. Carbohydrate-Binding Module Family 32.
    CBM40. Carbohydrate-Binding Module Family 40.
    GH33. Glycoside Hydrolase Family 33.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    SialidaseImported
    Gene namesi
    Name:nanJImported
    Ordered Locus Names:CPF_0532Imported
    OrganismiClostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)Imported
    Taxonomic identifieri195103 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001823: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi195103.CPF_0532.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2V73X-ray2.20A/B181-367[»]
    2VO8X-ray1.70A939-1081[»]
    ProteinModelPortaliQ0TTQ4.
    SMRiQ0TTQ4. Positions 44-180, 185-367, 378-821.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ0TTQ4.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 fibronectin type-III domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4409.
    HOGENOMiHOG000120093.
    KOiK01186.
    OMAiEMTASAT.
    OrthoDBiEOG61CM2G.

    Family and domain databases

    Gene3Di2.120.10.10. 2 hits.
    2.60.120.200. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 1 hit.
    InterProiIPR008965. Carb-bd_dom.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR004124. Glyco_hydro_33_N.
    IPR013783. Ig-like_fold.
    IPR026856. Sialidase_fam.
    IPR021984. Sialidase_pen_C.
    IPR011040. Sialidases.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    PfamiPF00754. F5_F8_type_C. 1 hit.
    PF00041. fn3. 1 hit.
    PF02973. Sialidase. 1 hit.
    PF12135. Sialidase_penC. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    SSF49384. SSF49384. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 2 hits.
    PROSITEiPS50022. FA58C_3. 1 hit.
    PS50853. FN3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0TTQ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSKKIIATL VASLVISNMG GYLVKANPNV NHKAVIIEDR QAIIETAIPQ     50
    SEMTASATSE EGQDPASSAI DGNTNTMWHT KWNGSDALPQ SLSVNLGSSR 100
    KVSSIAITPR TSGNNGFITK YEIHAINNGV EALVAEGTWE ENNLVKTVTF 150
    DSPIDAEEIK ITAIQGVGGF ASIAELNVYE IKGEVDEIAN YGNLKITKEE 200
    ERVNITGDLE KFSSLEEGTI VTRFNMNDTS IQSLIGLSDG NKANNYFSLY 250
    VSGGKVGYEL RRQEGNGDFN VHHSADVTFN RGINTLALKI EKGIGAKIFL 300
    NGSLVKTVSD PNIKFLNAIN LNSGFIGKTD RANGYNEYLF RGNIDFMNIY 350
    DKPVSDNYLL RKTGETKAPL EDSLLPDDVY KTQPVELFYP GYLESRGYRI 400
    PALETTKKGT VLASIDVRNN GDHDAPNNNI DVGIRRKEVN GEWEEGKVIL 450
    DYPGKSAAID TSLMSATIEE NGIEKERIFL IVTHFPEGYG FPNTEGGSGY 500
    REIDGKYYFI LKDAQNNEYT VREDGIVYNS EGNQTDYVMK NDKTLIQNGE 550
    EVGNALLSNS PLKAVGTAHI EMIYSDDDGK TWSEPEDLNP GLKKEWMKFF 600
    GTAPGKGIQI KNGEHKDRLI FPIYYTNQNN FQSSAVIYSD DFGETWKLGE 650
    SPIDTASVSS ETVSSGTQLT ECQVVEMPNG QLKLFMRNTG SYTRIATSFD 700
    GGATWHDEVP EDTSLREPYC QLSVINYSGK INGKDAIIFS NPDASSRVNG 750
    SVKVGLINEN GTYDNGEPRY EFDWIYNKTV KPGSFAYSCL TELPDGNLGL 800
    FYEGEGAGRM AYTEFDLNYL KFNASEDSPS ASVQSIEVLD EDLAYNSGEE 850
    VSIKVNFNQL VSIIGDRKIT LDIGGVDVPL NMVNYEGKSS AIFKGTIPEG 900
    INQGNYEIKL KENNTLELNT VYNKVSTFNG LDNTGINVQI GELKTTVGNS 950
    TIKVNDEVQV GSAFEAILGI EGLNGDTEVY SAEYLFEYNA EAFILNEITS 1000
    FNDSLFVKSK EVEPGKVRIL VASLGNEIEK DSDLVKVNLT PKISSELEVL 1050
    GLTTALVGAG DGNTHDLELS SKEVKINEEA SGEIVVNPVQ NFEIPEINKK 1100
    NVKLTWNAPI TTEGLEGYVI YKDGKKLSEV PAESTEFVVS KLNRHTIYNF 1150
    KVAAKYSNGE LSAKESKTIR TAR 1173
    Length:1,173
    Mass (Da):128,883
    Last modified:September 5, 2006 - v1
    Checksum:iD5A7CC27735851FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000246 Genomic DNA. Translation: ABG84247.1.
    RefSeqiWP_011590241.1. NC_008261.1.
    YP_694986.1. NC_008261.1.

    Genome annotation databases

    EnsemblBacteriaiABG84247; ABG84247; CPF_0532.
    GeneIDi4202243.
    KEGGicpf:CPF_0532.
    PATRICi19483368. VBICloPer106549_0511.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000246 Genomic DNA. Translation: ABG84247.1 .
    RefSeqi WP_011590241.1. NC_008261.1.
    YP_694986.1. NC_008261.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2V73 X-ray 2.20 A/B 181-367 [» ]
    2VO8 X-ray 1.70 A 939-1081 [» ]
    ProteinModelPortali Q0TTQ4.
    SMRi Q0TTQ4. Positions 44-180, 185-367, 378-821.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 195103.CPF_0532.

    Protein family/group databases

    CAZyi CBM32. Carbohydrate-Binding Module Family 32.
    CBM40. Carbohydrate-Binding Module Family 40.
    GH33. Glycoside Hydrolase Family 33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG84247 ; ABG84247 ; CPF_0532 .
    GeneIDi 4202243.
    KEGGi cpf:CPF_0532.
    PATRICi 19483368. VBICloPer106549_0511.

    Phylogenomic databases

    eggNOGi COG4409.
    HOGENOMi HOG000120093.
    KOi K01186.
    OMAi EMTASAT.
    OrthoDBi EOG61CM2G.

    Enzyme and pathway databases

    BioCyci CPER195103:GHAW-547-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q0TTQ4.

    Family and domain databases

    Gene3Di 2.120.10.10. 2 hits.
    2.60.120.200. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 1 hit.
    InterProi IPR008965. Carb-bd_dom.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR004124. Glyco_hydro_33_N.
    IPR013783. Ig-like_fold.
    IPR026856. Sialidase_fam.
    IPR021984. Sialidase_pen_C.
    IPR011040. Sialidases.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    Pfami PF00754. F5_F8_type_C. 1 hit.
    PF00041. fn3. 1 hit.
    PF02973. Sialidase. 1 hit.
    PF12135. Sialidase_penC. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    SSF49384. SSF49384. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 2 hits.
    PROSITEi PS50022. FA58C_3. 1 hit.
    PS50853. FN3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13124 / NCTC 8237 / Type AImported.
    2. "Carbohydrate recognition by a large sialidase toxin from Clostridium perfringens."
      Boraston A.B., Ficko-Blean E., Healey M.
      Biochemistry 46:11352-11360(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 181-367 IN COMPLEX WITH CALCIUM.
    3. "Structural basis of Clostridium perfringens toxin complex formation."
      Adams J.J., Gregg K., Bayer E.A., Boraston A.B., Smith S.P.
      Proc. Natl. Acad. Sci. U.S.A. 105:12194-12199(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 939-1081.

    Entry informationi

    Entry nameiQ0TTQ4_CLOP1
    AccessioniPrimary (citable) accession number: Q0TTQ4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3