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Q0TTQ4

- Q0TTQ4_CLOP1

UniProt

Q0TTQ4 - Q0TTQ4_CLOP1

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Protein
Submitted name: Sialidase
Gene
nanJ, CPF_0532
Organism
Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi225 – 2251Calcium 1Imported
Metal bindingi226 – 2261Calcium 1; via carbonyl oxygenImported
Metal bindingi281 – 2811Calcium 1; via carbonyl oxygenImported
Metal bindingi330 – 3301Calcium 2Imported
Metal bindingi331 – 3311Calcium 2; via carbonyl oxygenImported
Metal bindingi337 – 3371Calcium 2Imported

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. exo-alpha-sialidase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumImported, Metal-bindingImported

Enzyme and pathway databases

BioCyciCPER195103:GHAW-547-MONOMER.

Protein family/group databases

CAZyiCBM32. Carbohydrate-Binding Module Family 32.
CBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
SialidaseImported
Gene namesi
Name:nanJImported
Ordered Locus Names:CPF_0532Imported
OrganismiClostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)Imported
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001823: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_0532.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2V73X-ray2.20A/B181-367[»]
2VO8X-ray1.70A939-1081[»]
ProteinModelPortaliQ0TTQ4.
SMRiQ0TTQ4. Positions 44-180, 185-367, 378-821.

Miscellaneous databases

EvolutionaryTraceiQ0TTQ4.

Family & Domainsi

Sequence similaritiesi

Contains 1 fibronectin type-III domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG4409.
HOGENOMiHOG000120093.
KOiK01186.
OMAiEMTASAT.
OrthoDBiEOG61CM2G.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR008965. Carb-bd_dom.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR003961. Fibronectin_type3.
IPR008979. Galactose-bd-like.
IPR004124. Glyco_hydro_33_N.
IPR013783. Ig-like_fold.
IPR026856. Sialidase_fam.
IPR021984. Sialidase_pen_C.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF00041. fn3. 1 hit.
PF02973. Sialidase. 1 hit.
PF12135. Sialidase_penC. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49384. SSF49384. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
PROSITEiPS50022. FA58C_3. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0TTQ4-1 [UniParc]FASTAAdd to Basket

« Hide

MKSKKIIATL VASLVISNMG GYLVKANPNV NHKAVIIEDR QAIIETAIPQ     50
SEMTASATSE EGQDPASSAI DGNTNTMWHT KWNGSDALPQ SLSVNLGSSR 100
KVSSIAITPR TSGNNGFITK YEIHAINNGV EALVAEGTWE ENNLVKTVTF 150
DSPIDAEEIK ITAIQGVGGF ASIAELNVYE IKGEVDEIAN YGNLKITKEE 200
ERVNITGDLE KFSSLEEGTI VTRFNMNDTS IQSLIGLSDG NKANNYFSLY 250
VSGGKVGYEL RRQEGNGDFN VHHSADVTFN RGINTLALKI EKGIGAKIFL 300
NGSLVKTVSD PNIKFLNAIN LNSGFIGKTD RANGYNEYLF RGNIDFMNIY 350
DKPVSDNYLL RKTGETKAPL EDSLLPDDVY KTQPVELFYP GYLESRGYRI 400
PALETTKKGT VLASIDVRNN GDHDAPNNNI DVGIRRKEVN GEWEEGKVIL 450
DYPGKSAAID TSLMSATIEE NGIEKERIFL IVTHFPEGYG FPNTEGGSGY 500
REIDGKYYFI LKDAQNNEYT VREDGIVYNS EGNQTDYVMK NDKTLIQNGE 550
EVGNALLSNS PLKAVGTAHI EMIYSDDDGK TWSEPEDLNP GLKKEWMKFF 600
GTAPGKGIQI KNGEHKDRLI FPIYYTNQNN FQSSAVIYSD DFGETWKLGE 650
SPIDTASVSS ETVSSGTQLT ECQVVEMPNG QLKLFMRNTG SYTRIATSFD 700
GGATWHDEVP EDTSLREPYC QLSVINYSGK INGKDAIIFS NPDASSRVNG 750
SVKVGLINEN GTYDNGEPRY EFDWIYNKTV KPGSFAYSCL TELPDGNLGL 800
FYEGEGAGRM AYTEFDLNYL KFNASEDSPS ASVQSIEVLD EDLAYNSGEE 850
VSIKVNFNQL VSIIGDRKIT LDIGGVDVPL NMVNYEGKSS AIFKGTIPEG 900
INQGNYEIKL KENNTLELNT VYNKVSTFNG LDNTGINVQI GELKTTVGNS 950
TIKVNDEVQV GSAFEAILGI EGLNGDTEVY SAEYLFEYNA EAFILNEITS 1000
FNDSLFVKSK EVEPGKVRIL VASLGNEIEK DSDLVKVNLT PKISSELEVL 1050
GLTTALVGAG DGNTHDLELS SKEVKINEEA SGEIVVNPVQ NFEIPEINKK 1100
NVKLTWNAPI TTEGLEGYVI YKDGKKLSEV PAESTEFVVS KLNRHTIYNF 1150
KVAAKYSNGE LSAKESKTIR TAR 1173
Length:1,173
Mass (Da):128,883
Last modified:September 5, 2006 - v1
Checksum:iD5A7CC27735851FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG84247.1.
RefSeqiWP_011590241.1. NC_008261.1.
YP_694986.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG84247; ABG84247; CPF_0532.
GeneIDi4202243.
KEGGicpf:CPF_0532.
PATRICi19483368. VBICloPer106549_0511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG84247.1 .
RefSeqi WP_011590241.1. NC_008261.1.
YP_694986.1. NC_008261.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2V73 X-ray 2.20 A/B 181-367 [» ]
2VO8 X-ray 1.70 A 939-1081 [» ]
ProteinModelPortali Q0TTQ4.
SMRi Q0TTQ4. Positions 44-180, 185-367, 378-821.
ModBasei Search...

Protein-protein interaction databases

STRINGi 195103.CPF_0532.

Protein family/group databases

CAZyi CBM32. Carbohydrate-Binding Module Family 32.
CBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG84247 ; ABG84247 ; CPF_0532 .
GeneIDi 4202243.
KEGGi cpf:CPF_0532.
PATRICi 19483368. VBICloPer106549_0511.

Phylogenomic databases

eggNOGi COG4409.
HOGENOMi HOG000120093.
KOi K01186.
OMAi EMTASAT.
OrthoDBi EOG61CM2G.

Enzyme and pathway databases

BioCyci CPER195103:GHAW-547-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q0TTQ4.

Family and domain databases

Gene3Di 2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR008965. Carb-bd_dom.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR003961. Fibronectin_type3.
IPR008979. Galactose-bd-like.
IPR004124. Glyco_hydro_33_N.
IPR013783. Ig-like_fold.
IPR026856. Sialidase_fam.
IPR021984. Sialidase_pen_C.
IPR011040. Sialidases.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
Pfami PF00754. F5_F8_type_C. 1 hit.
PF00041. fn3. 1 hit.
PF02973. Sialidase. 1 hit.
PF12135. Sialidase_penC. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF49384. SSF49384. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
PROSITEi PS50022. FA58C_3. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13124 / NCTC 8237 / Type A.
  2. "Carbohydrate recognition by a large sialidase toxin from Clostridium perfringens."
    Boraston A.B., Ficko-Blean E., Healey M.
    Biochemistry 46:11352-11360(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 181-367 IN COMPLEX WITH CALCIUM.
  3. "Structural basis of Clostridium perfringens toxin complex formation."
    Adams J.J., Gregg K., Bayer E.A., Boraston A.B., Smith S.P.
    Proc. Natl. Acad. Sci. U.S.A. 105:12194-12199(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 939-1081.

Entry informationi

Entry nameiQ0TTQ4_CLOP1
AccessioniPrimary (citable) accession number: Q0TTQ4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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