Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q0TTQ4

- Q0TTQ4_CLOP1

UniProt

Q0TTQ4 - Q0TTQ4_CLOP1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Sialidase

Gene

nanJ

Organism
Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi225 – 2251Calcium 1Imported
Metal bindingi226 – 2261Calcium 1; via carbonyl oxygenImported
Metal bindingi281 – 2811Calcium 1; via carbonyl oxygenImported
Metal bindingi330 – 3301Calcium 2Imported
Metal bindingi331 – 3311Calcium 2; via carbonyl oxygenImported
Metal bindingi337 – 3371Calcium 2Imported

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. exo-alpha-sialidase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumImported, Metal-bindingImported

Enzyme and pathway databases

BioCyciCPER195103:GHAW-547-MONOMER.

Protein family/group databases

CAZyiCBM32. Carbohydrate-Binding Module Family 32.
CBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
SialidaseImported
Gene namesi
Name:nanJImported
Ordered Locus Names:CPF_0532Imported
OrganismiClostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)Imported
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001823: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_0532.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2V73X-ray2.20A/B181-367[»]
2VO8X-ray1.70A939-1081[»]
ProteinModelPortaliQ0TTQ4.
SMRiQ0TTQ4. Positions 44-180, 185-367, 378-821.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ0TTQ4.

Family & Domainsi

Sequence similaritiesi

Contains 1 fibronectin type-III domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG4409.
HOGENOMiHOG000120093.
KOiK01186.
OMAiEMTASAT.
OrthoDBiEOG61CM2G.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR008965. Carb-bd_dom.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR013320. ConA-like_dom.
IPR003961. Fibronectin_type3.
IPR008979. Galactose-bd-like.
IPR004124. Glyco_hydro_33_N.
IPR013783. Ig-like_fold.
IPR026856. Sialidase_fam.
IPR021984. Sialidase_pen_C.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF00041. fn3. 1 hit.
PF02973. Sialidase. 1 hit.
PF12135. Sialidase_penC. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49384. SSF49384. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
PROSITEiPS50022. FA58C_3. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0TTQ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSKKIIATL VASLVISNMG GYLVKANPNV NHKAVIIEDR QAIIETAIPQ
60 70 80 90 100
SEMTASATSE EGQDPASSAI DGNTNTMWHT KWNGSDALPQ SLSVNLGSSR
110 120 130 140 150
KVSSIAITPR TSGNNGFITK YEIHAINNGV EALVAEGTWE ENNLVKTVTF
160 170 180 190 200
DSPIDAEEIK ITAIQGVGGF ASIAELNVYE IKGEVDEIAN YGNLKITKEE
210 220 230 240 250
ERVNITGDLE KFSSLEEGTI VTRFNMNDTS IQSLIGLSDG NKANNYFSLY
260 270 280 290 300
VSGGKVGYEL RRQEGNGDFN VHHSADVTFN RGINTLALKI EKGIGAKIFL
310 320 330 340 350
NGSLVKTVSD PNIKFLNAIN LNSGFIGKTD RANGYNEYLF RGNIDFMNIY
360 370 380 390 400
DKPVSDNYLL RKTGETKAPL EDSLLPDDVY KTQPVELFYP GYLESRGYRI
410 420 430 440 450
PALETTKKGT VLASIDVRNN GDHDAPNNNI DVGIRRKEVN GEWEEGKVIL
460 470 480 490 500
DYPGKSAAID TSLMSATIEE NGIEKERIFL IVTHFPEGYG FPNTEGGSGY
510 520 530 540 550
REIDGKYYFI LKDAQNNEYT VREDGIVYNS EGNQTDYVMK NDKTLIQNGE
560 570 580 590 600
EVGNALLSNS PLKAVGTAHI EMIYSDDDGK TWSEPEDLNP GLKKEWMKFF
610 620 630 640 650
GTAPGKGIQI KNGEHKDRLI FPIYYTNQNN FQSSAVIYSD DFGETWKLGE
660 670 680 690 700
SPIDTASVSS ETVSSGTQLT ECQVVEMPNG QLKLFMRNTG SYTRIATSFD
710 720 730 740 750
GGATWHDEVP EDTSLREPYC QLSVINYSGK INGKDAIIFS NPDASSRVNG
760 770 780 790 800
SVKVGLINEN GTYDNGEPRY EFDWIYNKTV KPGSFAYSCL TELPDGNLGL
810 820 830 840 850
FYEGEGAGRM AYTEFDLNYL KFNASEDSPS ASVQSIEVLD EDLAYNSGEE
860 870 880 890 900
VSIKVNFNQL VSIIGDRKIT LDIGGVDVPL NMVNYEGKSS AIFKGTIPEG
910 920 930 940 950
INQGNYEIKL KENNTLELNT VYNKVSTFNG LDNTGINVQI GELKTTVGNS
960 970 980 990 1000
TIKVNDEVQV GSAFEAILGI EGLNGDTEVY SAEYLFEYNA EAFILNEITS
1010 1020 1030 1040 1050
FNDSLFVKSK EVEPGKVRIL VASLGNEIEK DSDLVKVNLT PKISSELEVL
1060 1070 1080 1090 1100
GLTTALVGAG DGNTHDLELS SKEVKINEEA SGEIVVNPVQ NFEIPEINKK
1110 1120 1130 1140 1150
NVKLTWNAPI TTEGLEGYVI YKDGKKLSEV PAESTEFVVS KLNRHTIYNF
1160 1170
KVAAKYSNGE LSAKESKTIR TAR
Length:1,173
Mass (Da):128,883
Last modified:September 5, 2006 - v1
Checksum:iD5A7CC27735851FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG84247.1.
RefSeqiYP_694986.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG84247; ABG84247; CPF_0532.
GeneIDi4202243.
KEGGicpf:CPF_0532.
PATRICi19483368. VBICloPer106549_0511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG84247.1 .
RefSeqi YP_694986.1. NC_008261.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2V73 X-ray 2.20 A/B 181-367 [» ]
2VO8 X-ray 1.70 A 939-1081 [» ]
ProteinModelPortali Q0TTQ4.
SMRi Q0TTQ4. Positions 44-180, 185-367, 378-821.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195103.CPF_0532.

Protein family/group databases

CAZyi CBM32. Carbohydrate-Binding Module Family 32.
CBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG84247 ; ABG84247 ; CPF_0532 .
GeneIDi 4202243.
KEGGi cpf:CPF_0532.
PATRICi 19483368. VBICloPer106549_0511.

Phylogenomic databases

eggNOGi COG4409.
HOGENOMi HOG000120093.
KOi K01186.
OMAi EMTASAT.
OrthoDBi EOG61CM2G.

Enzyme and pathway databases

BioCyci CPER195103:GHAW-547-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q0TTQ4.

Family and domain databases

Gene3Di 2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR008965. Carb-bd_dom.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR013320. ConA-like_dom.
IPR003961. Fibronectin_type3.
IPR008979. Galactose-bd-like.
IPR004124. Glyco_hydro_33_N.
IPR013783. Ig-like_fold.
IPR026856. Sialidase_fam.
IPR021984. Sialidase_pen_C.
IPR011040. Sialidases.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
Pfami PF00754. F5_F8_type_C. 1 hit.
PF00041. fn3. 1 hit.
PF02973. Sialidase. 1 hit.
PF12135. Sialidase_penC. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF49384. SSF49384. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
PROSITEi PS50022. FA58C_3. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13124 / NCTC 8237 / Type AImported.
  2. "Carbohydrate recognition by a large sialidase toxin from Clostridium perfringens."
    Boraston A.B., Ficko-Blean E., Healey M.
    Biochemistry 46:11352-11360(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 181-367 IN COMPLEX WITH CALCIUM.
  3. "Structural basis of Clostridium perfringens toxin complex formation."
    Adams J.J., Gregg K., Bayer E.A., Boraston A.B., Smith S.P.
    Proc. Natl. Acad. Sci. U.S.A. 105:12194-12199(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 939-1081.

Entry informationi

Entry nameiQ0TTQ4_CLOP1
AccessioniPrimary (citable) accession number: Q0TTQ4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3