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Q0TTD0 (SYL_CLOP1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:CPF_0657
OrganismClostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A) [Complete proteome] [HAMAP]
Taxonomic identifier195103 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length816 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 816816Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009329

Regions

Motif40 – 5112"HIGH" region HAMAP-Rule MF_00049
Motif576 – 5805"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5791ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0TTD0 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 2A5FDC10D11E5289

FASTA81692,693
        10         20         30         40         50         60 
MGNYSTAIDK KWQEKWAESG LYKFDPNKEG EKLYVLEMFS YPSGSQLHAG HWFNYGPVDS 

        70         80         90        100        110        120 
WARFKRMQGY NVFQPMGFDA FGLPAENFAI KTGIHPQDST IKNIAKMEEQ LKAMGAMFNW 

       130        140        150        160        170        180 
ENEVVTCSPE YYKWTQWLFL KLYEKGLAYR KKAPVNWCPS CQTVLANEQV VDGACERCST 

       190        200        210        220        230        240 
EVTKKDLTQW FFKITDYADE LLDKLDDLDW PEKTVSMQKH WIGRSTGSQV NFKVKDSDLN 

       250        260        270        280        290        300 
FDVFTTRVDT LCGVSYVVLA PENPLVDEIV SAEQKEAVEN YKEEAKKQSD IERQSISREK 

       310        320        330        340        350        360 
TGVFTGAYAI HPLTGKEVPI WVGDYVLATY GTGAVMAVPA HDERDFAFAE KFNLPINRVI 

       370        380        390        400        410        420 
EAKDGSETNL PFCEHGILVN SGEFDGLTTD EAKEKIVEKL ASMGLGEKKV NFRLRDWLVS 

       430        440        450        460        470        480 
RQRYWGAPIP VVYCEECGIV PVPESQLPVE LPYDVEFAPD GKSPLAKSEA FVNTTCPHCG 

       490        500        510        520        530        540 
KPAKRETDTL DTFVCSSWYY LRYPDNKNTE APFNPELINK MLPVDKYVGG PEHACMHLLY 

       550        560        570        580        590        600 
ARFITKALRD MGYLNFDEPF TSLTHQGLIL GPDGLKMSKS KGNTISPDDY IKEYGADVFR 

       610        620        630        640        650        660 
MYLMFGFAYT EGGAWSDDGI KSVNRFVERI ERIIDTAREA ISKGENNKTT MDKAEKELNY 

       670        680        690        700        710        720 
WRHNTIKSVT DDTDKLQFNT AIARMMEFIN ALSKYTQEKE MNLDFLKDVV SDYLRLLAPF 

       730        740        750        760        770        780 
APHFSEEQWS LLGNSYSIFN EAWPKFDPKA LVKDEVEIAI QVNGKIKNKI MVSSDLDEEG 

       790        800        810 
IKAAALADEK IIASTEGKTV VKVIVIKGRL VNIVVK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000246 Genomic DNA. Translation: ABG83404.1.
RefSeqYP_695110.1. NC_008261.1.

3D structure databases

ProteinModelPortalQ0TTD0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING195103.CPF_0657.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG83404; ABG83404; CPF_0657.
GeneID4203513.
KEGGcpf:CPF_0657.
PATRIC19483620. VBICloPer106549_0633.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycCPER195103:GHAW-675-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL_CLOP1
AccessionPrimary (citable) accession number: Q0TTD0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries