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Q0TTD0

- SYL_CLOP1

UniProt

Q0TTD0 - SYL_CLOP1

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPER195103:GHAW-675-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CPF_0657
OrganismiClostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001823: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 816816Leucine--tRNA ligasePRO_1000009329Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_0657.

Structurei

3D structure databases

ProteinModelPortaliQ0TTD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi576 – 5805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0TTD0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNYSTAIDK KWQEKWAESG LYKFDPNKEG EKLYVLEMFS YPSGSQLHAG
60 70 80 90 100
HWFNYGPVDS WARFKRMQGY NVFQPMGFDA FGLPAENFAI KTGIHPQDST
110 120 130 140 150
IKNIAKMEEQ LKAMGAMFNW ENEVVTCSPE YYKWTQWLFL KLYEKGLAYR
160 170 180 190 200
KKAPVNWCPS CQTVLANEQV VDGACERCST EVTKKDLTQW FFKITDYADE
210 220 230 240 250
LLDKLDDLDW PEKTVSMQKH WIGRSTGSQV NFKVKDSDLN FDVFTTRVDT
260 270 280 290 300
LCGVSYVVLA PENPLVDEIV SAEQKEAVEN YKEEAKKQSD IERQSISREK
310 320 330 340 350
TGVFTGAYAI HPLTGKEVPI WVGDYVLATY GTGAVMAVPA HDERDFAFAE
360 370 380 390 400
KFNLPINRVI EAKDGSETNL PFCEHGILVN SGEFDGLTTD EAKEKIVEKL
410 420 430 440 450
ASMGLGEKKV NFRLRDWLVS RQRYWGAPIP VVYCEECGIV PVPESQLPVE
460 470 480 490 500
LPYDVEFAPD GKSPLAKSEA FVNTTCPHCG KPAKRETDTL DTFVCSSWYY
510 520 530 540 550
LRYPDNKNTE APFNPELINK MLPVDKYVGG PEHACMHLLY ARFITKALRD
560 570 580 590 600
MGYLNFDEPF TSLTHQGLIL GPDGLKMSKS KGNTISPDDY IKEYGADVFR
610 620 630 640 650
MYLMFGFAYT EGGAWSDDGI KSVNRFVERI ERIIDTAREA ISKGENNKTT
660 670 680 690 700
MDKAEKELNY WRHNTIKSVT DDTDKLQFNT AIARMMEFIN ALSKYTQEKE
710 720 730 740 750
MNLDFLKDVV SDYLRLLAPF APHFSEEQWS LLGNSYSIFN EAWPKFDPKA
760 770 780 790 800
LVKDEVEIAI QVNGKIKNKI MVSSDLDEEG IKAAALADEK IIASTEGKTV
810
VKVIVIKGRL VNIVVK
Length:816
Mass (Da):92,693
Last modified:September 5, 2006 - v1
Checksum:i2A5FDC10D11E5289
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG83404.1.
RefSeqiWP_003457020.1. NC_008261.1.
YP_695110.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG83404; ABG83404; CPF_0657.
GeneIDi4203513.
KEGGicpf:CPF_0657.
PATRICi19483620. VBICloPer106549_0633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG83404.1 .
RefSeqi WP_003457020.1. NC_008261.1.
YP_695110.1. NC_008261.1.

3D structure databases

ProteinModelPortali Q0TTD0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195103.CPF_0657.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG83404 ; ABG83404 ; CPF_0657 .
GeneIDi 4203513.
KEGGi cpf:CPF_0657.
PATRICi 19483620. VBICloPer106549_0633.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CPER195103:GHAW-675-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13124 / NCTC 8237 / Type A.

Entry informationi

Entry nameiSYL_CLOP1
AccessioniPrimary (citable) accession number: Q0TTD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3