Q0TTB8 (Q0TTB8_CLOP1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Deoxyuridine 5-triphosphate nucleotidohydrolase EMBL ABG83133.1
EC=3.6.1.23 EMBL ABG83133.1

Gene names

Name:	dut EMBL ABG83133.1
Ordered Locus Names:	CPF_0669

Organism

Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A) [Complete proteome] [HAMAP] EMBL ABG83133.1

Taxonomic identifier

195103 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium perfringens

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. SAAS SAAS008181
Cofactor	Magnesium By similarity. SAAS SAAS008181

Ontologies

Keywords
Biological process	Nucleotide metabolism SAAS SAAS008181
Ligand	Magnesium SAAS SAAS008181
Molecular function	Hydrolase SAAS SAAS008181 EMBL ABG83133.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0TTB8 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: B182485B96A81E25	FASTA	216	24,225
	10 20 30 40 50 60 MAGEQRVRDV YIQYDKNGET PKYETPLAAG ADLFAAEDMV IRPFEKVAIP LGLKFAIPDN 70 80 90 100 110 120 MELQIRARSG LSLRTNLKIS NSIGTIDADS VSDISVILEN NYNIANLPYE IANDISILDD 130 140 150 160 170 180 LKNNYTEVRL SDYLESKGHD ISSYEDEGKK AYKKLLKTYI YLDKNGNPYG TIYIKKGNRI 190 200 210 AQMVLAKYYK ANFIKTDDVS KLKSVNRGGG FGHTGF

References

[1]

"Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens." Myers G.S., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., Deboy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Khouri H. , Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B., Paulsen I.T. Genome Res. 16:1031-1040(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13124 / NCTC 8237 / Type A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000246 Genomic DNA. Translation: ABG83133.1.
RefSeq	YP_695122.1. NC_008261.1.
3D structure databases
ProteinModelPortal	Q0TTB8.
ModBase	Search...
Protein-protein interaction databases
STRING	195103.CPF_0669.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABG83133; ABG83133; CPF_0669.
GeneID	4202052.
KEGG	cpf:CPF_0669.
PATRIC	19483642. VBICloPer106549_0644.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0756.
HOGENOM	HOG000028966.
KO	K01520.
OMA	NIANLPY.
ProtClustDB	CLSK899219.
Enzyme and pathway databases
BioCyc	CPER195103:GHAW-687-MONOMER.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q0TTB8_CLOP1

Accession

Primary (citable) accession number: Q0TTB8

Entry history

Integrated into UniProtKB/TrEMBL:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	May 29, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)