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Q0TTB2

- PUR5_CLOP1

UniProt

Q0TTB2 - PUR5_CLOP1

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, CPF_0675
Organism
Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPER195103:GHAW-693-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:CPF_0675
OrganismiClostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001823: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_0000258347Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_0675.

Structurei

3D structure databases

ProteinModelPortaliQ0TTB2.
SMRiQ0TTB2. Positions 16-332.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0TTB2-1 [UniParc]FASTAAdd to Basket

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MLTYKEAGVN IEEGYRSVKL IKEYAKKTMS EYVLNGLGSF AGMVELPEGY    50
KKPVLVSGTD GVGTKLDIAC KKRKFDTVGI DCVAMCVNDI LCHGAKPLFF 100
LDYIACGKLE AEVSSDLVKG VAEGCIESQC SLIGGETAEM PGMYKEGDYD 150
IAGFAVGIVD KDKIINGKDI KSGDKLIGIA SSGVHSNGYS LIRKVFKNLD 200
EDFNGKAIWE ELLTPTKIYV KPVLSLLEKF NIKGMAHVTG GGFYENLPRM 250
LSKEGLSIVI NKNSYEIPEI FKKLMELGVK EEEMYNTFNM GIGFVLCVEE 300
DEVEEVLKEL SKQGEKAFEI GYINAGGEGV CIK 333
Length:333
Mass (Da):36,440
Last modified:September 5, 2006 - v1
Checksum:i78B8A6FCA8B44275
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG84389.1.
RefSeqiYP_695128.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG84389; ABG84389; CPF_0675.
GeneIDi4201607.
KEGGicpf:CPF_0675.
PATRICi19483654. VBICloPer106549_0650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG84389.1 .
RefSeqi YP_695128.1. NC_008261.1.

3D structure databases

ProteinModelPortali Q0TTB2.
SMRi Q0TTB2. Positions 16-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195103.CPF_0675.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG84389 ; ABG84389 ; CPF_0675 .
GeneIDi 4201607.
KEGGi cpf:CPF_0675.
PATRICi 19483654. VBICloPer106549_0650.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci CPER195103:GHAW-693-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13124 / NCTC 8237 / Type A.

Entry informationi

Entry nameiPUR5_CLOP1
AccessioniPrimary (citable) accession number: Q0TTB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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