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Protein
Submitted name:

Sialidase

Gene

nanI

Organism
Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi296 – 2961CalciumCombined sources
Metal bindingi298 – 2981CalciumCombined sources
Metal bindingi319 – 3191CalciumCombined sources
Metal bindingi320 – 3201Calcium; via carbonyl oxygenCombined sources

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BioCyciCPER195103:GHAW-739-MONOMER.

Protein family/group databases

CAZyiCBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
SialidaseImported
Gene namesi
Name:nanIImported
Ordered Locus Names:CPF_0721Imported
OrganismiClostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)Imported
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001823: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_0721.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4L2EX-ray1.90A243-691[»]
ProteinModelPortaliQ0TT67.
SMRiQ0TT67. Positions 42-236, 243-690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG4409.
HOGENOMiHOG000120086.
KOiK01186.
OMAiGGPKREN.
OrthoDBiEOG61CM2G.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF02973. Sialidase. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.

Sequencei

Sequence statusi: Complete.

Q0TT67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYKGITLIL TAAMVISGGN YVLVKGSTLD SGKNNSGYEI KVNNSENLSS
60 70 80 90 100
LGEYKDINLE SSNASNITYD LEKYKNLDEG TIVVRFNSKD SKIQSLLGIS
110 120 130 140 150
NSKTKNGYFN FYVTNSRVGF ELRNQKNEGN TQNGTENLVH MYKDVALNDG
160 170 180 190 200
DNTVALKIEK NKGYKLFLNG KMIKEVKDTN TKFLNNIENL DSAFIGKTNR
210 220 230 240 250
YGQSNEYNFK GNIGFMNIYN EPLGDDYLLS KTGETKAKEE VLVEGAVKTE
260 270 280 290 300
PVDLFHPGFL NSSNYRIPAL FKTKEGTLIA SIDARRQGGA DAPNNDIDTA
310 320 330 340 350
VRRSEDGGKT WDEGQIIMDY PDKSSVIDTT LIQDDETGRI FLLVTHFPSK
360 370 380 390 400
YGFWNAGLGS GFKNIDGKEY LCLYDSSGKE FTVRENVVYD KDGNKTEYTT
410 420 430 440 450
NALGDLFRNG TKIDNINSST APLKAKGTSY INLVYSDDDG KTWSEPQNIN
460 470 480 490 500
FQVKKDWMKF LGIAPGRGIQ IKNGEHKGRI VVPVYYTNEK GKQSSAVIYS
510 520 530 540 550
DDSGKNWTIG ESPNDNRKLE NGKIINSKTL SDDAPQLTEC QVVEMPNGQL
560 570 580 590 600
KLFMRNLSGY LNIATSFDGG ATWDETVEKD TNVLEPYCQL SVINYSQKID
610 620 630 640 650
GKDAVIFSNP NARSRSNGTV RIGLINQVGT YENGEPKYEF DWKYNKLVKP
660 670 680 690
GYYAYSCLTE LSNGNIGLLY EGTPSEEMSY IEMNLKYLES GANK
Length:694
Mass (Da):77,405
Last modified:September 5, 2006 - v1
Checksum:i1F36DE00F026E958
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000246 Genomic DNA. Translation: ABG83208.1.
RefSeqiYP_695173.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG83208; ABG83208; CPF_0721.
GeneIDi4202671.
KEGGicpf:CPF_0721.
PATRICi19483744. VBICloPer106549_0694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000246 Genomic DNA. Translation: ABG83208.1.
RefSeqiYP_695173.1. NC_008261.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4L2EX-ray1.90A243-691[»]
ProteinModelPortaliQ0TT67.
SMRiQ0TT67. Positions 42-236, 243-690.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi195103.CPF_0721.

Protein family/group databases

CAZyiCBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG83208; ABG83208; CPF_0721.
GeneIDi4202671.
KEGGicpf:CPF_0721.
PATRICi19483744. VBICloPer106549_0694.

Phylogenomic databases

eggNOGiCOG4409.
HOGENOMiHOG000120086.
KOiK01186.
OMAiGGPKREN.
OrthoDBiEOG61CM2G.

Enzyme and pathway databases

BioCyciCPER195103:GHAW-739-MONOMER.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF02973. Sialidase. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13124 / NCTC 8237 / Type AImported.

Entry informationi

Entry nameiQ0TT67_CLOP1
AccessioniPrimary (citable) accession number: Q0TT67
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: March 4, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.