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Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi76ZincUniRule annotation1
Metal bindingi79ZincUniRule annotation1
Metal bindingi147ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandGTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IUniRule annotation
Short name:
GTP-CH-IUniRule annotation
Gene namesi
Name:folEUniRule annotation
Ordered Locus Names:CPF_1274
OrganismiClostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001823 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000436831 – 185GTP cyclohydrolase 1Add BLAST185

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

Protein-protein interaction databases

STRINGi195103.CPF_1274.

Structurei

3D structure databases

ProteinModelPortaliQ0TRM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EUJ. Bacteria.
COG0302. LUCA.
HOGENOMiHOG000221222.
KOiK01495.
OMAiVEGEHLC.
OrthoDBiPOG091803LY.

Family and domain databases

HAMAPiMF_00223. FolE. 1 hit.
InterProiView protein in InterPro
IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiView protein in Pfam
PF01227. GTP_cyclohydroI. 1 hit.
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiView protein in PROSITE
PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0TRM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDKDKIREG MKLILEAIGE DINREGLIET PDRIARMYEE IFSGIGMNAK
60 70 80 90 100
EHLSKTFEVH SNDLVLEKDI TFYSMCEHHL VPFYGKVHIA YIPNGRVVGL
110 120 130 140 150
SKLARCVEVY SKKPQLQERL TTEIADSIME YLDAQGVMVV VEGEHMCMTM
160 170 180
RGVRKPGAKT VTTTYRGKFL EDESLKNDVF RMISM
Length:185
Mass (Da):21,181
Last modified:September 5, 2006 - v1
Checksum:i959BC0217EF3443C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000246 Genomic DNA. Translation: ABG84686.1.
RefSeqiWP_011590644.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG84686; ABG84686; CPF_1274.
GeneIDi29571612.
KEGGicpf:CPF_1274.
PATRICi19484820. VBICloPer106549_1230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000246 Genomic DNA. Translation: ABG84686.1.
RefSeqiWP_011590644.1. NC_008261.1.

3D structure databases

ProteinModelPortaliQ0TRM0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi195103.CPF_1274.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG84686; ABG84686; CPF_1274.
GeneIDi29571612.
KEGGicpf:CPF_1274.
PATRICi19484820. VBICloPer106549_1230.

Phylogenomic databases

eggNOGiENOG4105EUJ. Bacteria.
COG0302. LUCA.
HOGENOMiHOG000221222.
KOiK01495.
OMAiVEGEHLC.
OrthoDBiPOG091803LY.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Family and domain databases

HAMAPiMF_00223. FolE. 1 hit.
InterProiView protein in InterPro
IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiView protein in Pfam
PF01227. GTP_cyclohydroI. 1 hit.
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiView protein in PROSITE
PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGCH1_CLOP1
AccessioniPrimary (citable) accession number: Q0TRM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: February 15, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.