Reviewed, UniProtKB/Swiss-Prot Q0TRE4 (CAPPA_CLOP1)

Names and origin

Protein names

Recommended name:
    Phosphoenolpyruvate carboxylase
      Short name=PEPCase
      Short name=PEPC
    EC=4.1.1.31

Gene names

Name:	ppcA
Ordered Locus Names:	CPF_1350

Organism

Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

195103 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	537 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.
Catalytic activity	Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + CO2. HAMAP MF_01904
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle. HAMAP MF_01904
Sequence similarities	Belongs to the PEPCase type 2 family.

Ontologies

Keywords
Biological process	Carbon dioxide fixation Tricarboxylic acid cycle
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbon utilization by fixation of carbon dioxide Inferred from electronic annotation. Source: HAMAP tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular function	phosphoenolpyruvate carboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 537	537	Phosphoenolpyruvate carboxylase HAMAP MF_01904		PRO_0000309594

Sequences

	Sequence		Length	Mass (Da)
	Q0TRE4-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: CF43D5B22E28014C	FASTA	537	60,393
	10 20 30 40 50 60 MKIPCSMMTQ HPDNVETYIS IQQEPAEAIK GLTPQDKGGL GIEEVMIDFE GKLTPYHQTS 70 80 90 100 110 120 QIALGLISNG IIPGKDVRVT PRIPNANKES VFRQLMSIMS IIETNVQSKE LTGIPAISEV 130 140 150 160 170 180 VVPMIETGKE ISEFQDRVNS VVDMGNKNYK TKLDLNSVRI IPLVEDVPAL ANIDRILDEH 190 200 210 220 230 240 YEIEKSKGHV LKDLRIMIAR SDTAMSYGLI SGVLSVLMAV DGAYKWGEKH GVTISPILGC 250 260 270 280 290 300 GSLPFRGHFS EENIDEILAT YSGIKTFTFQ SALRYDHGEE ATKHAVNELK AKIAESKPRN 310 320 330 340 350 360 FSEEDKDLMK EFIGICSKHY LQTFLKVIDT VSFVSDFIPK NRDRLTKAKT GLEYNREVAN 370 380 390 400 410 420 LDNVADLVKD EVLKQEILSI DNSKEYAVPR AISFTGAMYT LGMPPELMGM GRALNEIKTK 430 440 450 460 470 480 YGQEGIDKLL EIYPILRKDL AFAARFANGG VSKKIIDEEA RQEYKEDMKY VNEILNLGLD 490 500 510 520 530 YDFLNENEFY HTLLKTTKPI IMHLMGLEEN VMRNSTEELK ILNEWIVRMG KVRGSIG

References

[1]

"Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens." Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Khouri H. , Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B., Paulsen I.T. Genome Res. 16:1031-1040(2006) [PubMed: 16825665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000246 Genomic DNA. Translation: ABG83743.1.
RefSeq	YP_695796.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4202414.
GenomeReviews	Gene locus CPF_1350 in contig CP000246_GR.
KEGG	cpf:CPF_1350.
TIGR	CPF_1350.
Phylogenomic databases
HOGENOM	Q0TRE4.
OMA	Q0TRE4. RSDPAMN.
Family and domain databases
HAMAP	MF_01904. [Tree]
InterPro	IPR007566. PEnol-Pyrv_COase_arc. [Graphical view]
Pfam	PF04477. DUF557. 1 hit. [Graphical view]
PIRSF	PIRSF006677. UCP006677. 1 hit.
TIGRFAMs	TIGR02751. PEPCase_arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CAPPA_CLOP1

Accession

Primary (citable) accession number: Q0TRE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)