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Q0TRB0

- PYRF_CLOP1

UniProt

Q0TRB0 - PYRF_CLOP1

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Proton donorUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCPER195103:GHAW-1402-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:CPF_1384
OrganismiClostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001823: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Orotidine 5'-phosphate decarboxylasePRO_1000066465Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_1384.

Structurei

3D structure databases

ProteinModelPortaliQ0TRB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245747.
KOiK01591.
OMAiCRTSNAG.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0TRB0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIADKLFEKV EKNGVVCVGL DTSLDYIPEE FKSKFSNESD MLFAFNKEII
60 70 80 90 100
DATLDVSACF KVQIAYYEAL GLKGLESYKN TLSYLREKNA LIIADIKRGD
110 120 130 140 150
IAATAKMYAK AHFEGDFESD FITLNPYMGM DSIDPYLPYI EKNEKGVFVL
160 170 180 190 200
VRTSNKGAED IEYLEAGHGK KVYDVVGEKL NTLGKNYLGK HGYSSIGGVV
210 220 230 240 250
GCTHQEEAKE MRDKLDTMPF LIPGYGAQGG TAKDVAAYLK NGNGGIVNSS
260 270 280
RKILLAYKAM EDSKNFAECA RKEAISMRDS IREAILK
Length:287
Mass (Da):31,812
Last modified:September 5, 2006 - v1
Checksum:i038A878EC863960F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG83795.1.
RefSeqiWP_011590687.1. NC_008261.1.
YP_695830.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG83795; ABG83795; CPF_1384.
GeneIDi4203558.
KEGGicpf:CPF_1384.
PATRICi19485038. VBICloPer106549_1339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG83795.1 .
RefSeqi WP_011590687.1. NC_008261.1.
YP_695830.1. NC_008261.1.

3D structure databases

ProteinModelPortali Q0TRB0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195103.CPF_1384.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG83795 ; ABG83795 ; CPF_1384 .
GeneIDi 4203558.
KEGGi cpf:CPF_1384.
PATRICi 19485038. VBICloPer106549_1339.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245747.
KOi K01591.
OMAi CRTSNAG.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci CPER195103:GHAW-1402-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13124 / NCTC 8237 / Type A.

Entry informationi

Entry nameiPYRF_CLOP1
AccessioniPrimary (citable) accession number: Q0TRB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 5, 2006
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3