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Q0TRA5

- UPPP_CLOP1

UniProt

Q0TRA5 - UPPP_CLOP1

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, CPF_1390
Organism
Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCPER195103:GHAW-1408-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:CPF_1390
OrganismiClostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001823: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Reviewed predictionAdd
BLAST
Transmembranei47 – 6721Helical; Reviewed predictionAdd
BLAST
Transmembranei72 – 9221Helical; Reviewed predictionAdd
BLAST
Transmembranei111 – 13121Helical; Reviewed predictionAdd
BLAST
Transmembranei137 – 15721Helical; Reviewed predictionAdd
BLAST
Transmembranei209 – 23123Helical; Reviewed predictionAdd
BLAST
Transmembranei248 – 26821Helical; Reviewed predictionAdd
BLAST
Transmembranei283 – 30321Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Undecaprenyl-diphosphataseUniRule annotationPRO_0000290701Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_1390.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiWRKISSS.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0TRA5-1 [UniParc]FASTAAdd to Basket

« Hide

MGIDFLFILK ALIIAIVEGL TEFVPVSSTG HMILVGDLIH FNTQSGGFPE    50
MYEVVIQLGA ILAVVVLYWR KISSSVVEFL CYIFSFIGLK TSGDKRKYEK 100
RLAESETGFR FGINVIIGTI PAAILGLLFH DEIKEYLFST KTVAIGFIVG 150
GILLIVIENN FRKRAKRSKI VKDIDKMTYG QSLLVGCFQC LSLWPGMSRS 200
ASTIMGGWIS GLSTTVATEF TFFLAIPAMV GASGLDLFKF DYSQMNATNW 250
ISLILGFIVA FIVSLVVIDK FINYLKKKPM RVFAIYRVFA GIVLAILIFT 300
KVIS 304
Length:304
Mass (Da):33,729
Last modified:September 5, 2006 - v1
Checksum:i6112AC515B1D75D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG83114.1.
RefSeqiWP_011590690.1. NC_008261.1.
YP_695835.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG83114; ABG83114; CPF_1390.
GeneIDi4202324.
KEGGicpf:CPF_1390.
PATRICi19485048. VBICloPer106549_1344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG83114.1 .
RefSeqi WP_011590690.1. NC_008261.1.
YP_695835.1. NC_008261.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195103.CPF_1390.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG83114 ; ABG83114 ; CPF_1390 .
GeneIDi 4202324.
KEGGi cpf:CPF_1390.
PATRICi 19485048. VBICloPer106549_1344.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi WRKISSS.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci CPER195103:GHAW-1408-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13124 / NCTC 8237 / Type A.

Entry informationi

Entry nameiUPPP_CLOP1
AccessioniPrimary (citable) accession number: Q0TRA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi