Reviewed, UniProtKB/Swiss-Prot Q0TR21 (ADEC_CLOP1)

Names and origin

Protein names

Recommended name:
    Adenine deaminase
      Short name=Adenase
      Short name=Adenine aminase
    EC=3.5.4.2

Gene names

Name:	ade
Ordered Locus Names:	CPF_1476

Organism

Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

195103 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	568 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518
Cofactor	Manganese By similarity.
Sequence similarities	Belongs to the adenine deaminase family.

Ontologies

Keywords
Ligand	Manganese
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 568	568	Adenine deaminase HAMAP MF_01518		PRO_0000296720

Sequences

	Sequence		Length	Mass (Da)
	Q0TR21-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: EA2B76E0921E9E38	FASTA	568	64,186
	10 20 30 40 50 60 MQVELIIKNL NVYNSYFKKF IKGDILINKG KFLHIGKGYE DRLWSENVID GEGKYIIPGL 70 80 90 100 110 120 IDIHMHIESS MTIPREFSKA AIKHGVTTVV ADPHEIANVF GIRGIEEFIK FKGNLDIFYG 130 140 150 160 170 180 IPSSVPSTSS SLETTGEKIT HNEVKRLLEY DNIICLGEVM NFKDLIEDDD SNINKIINIS 190 200 210 220 230 240 KEKNIPLEGH CPKIQGVDLS LYIYRGVNGD HTQQSVGSLQ EKIQNGMFIE MQHKSMTLEN 250 260 270 280 290 300 IKFLIENNLY EHFALVTDDV MADKLVKGHL DEILKEAVKL GMSIENAIYA STYTPARRMN 310 320 330 340 350 360 LLDRGTIAPG KLADFILLDS IEDFNIYEVY KNGEMVFNRD KGLKEEFFED KSKLDYRFYN 370 380 390 400 410 420 SIELNNITKE SLEVKVPNKY KNKVNCRTMK VLKNTTFTEE GEVTLNVYNN ILQWEKSSCA 430 440 450 460 470 480 LIAVFERYGK NNNISFGLVE GEIIKEGAIA TTWAHDHHNL MVMGRNISDM TIAANEVINS 490 500 510 520 530 540 RGGYVVSKNN EVIAKLELPI GGIISDEPIE IIGEKLGEVR SAMRDLGYNH MNEIMSFSTL 550 560 SLPVSPALKI TDKGLIDVKK GSIVSLFK

References

[1]

"Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens." Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Khouri H. , Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B., Paulsen I.T. Genome Res. 16:1031-1040(2006) [PubMed: 16825665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000246 Genomic DNA. Translation: ABG82839.1.
RefSeq	YP_695919.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4202397.
GenomeReviews	Gene locus CPF_1476 in contig CP000246_GR.
KEGG	cpf:CPF_1476.
TIGR	CPF_1476.
Phylogenomic databases
HOGENOM	Q0TR21.
OMA	Q0TR21. LACNAGP.
Family and domain databases
HAMAP	MF_01518. [Tree]
InterPro	IPR006680. Amidohydro_1. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
ProDom	PD001248. Amidohydro_like. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

ADEC_CLOP1

Accession

Primary (citable) accession number: Q0TR21

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	September 5, 2006
Last modified:	May 5, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)