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Q0TQV3 (THIM_CLOP1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:CPF_1544
OrganismClostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A) [Complete proteome] [HAMAP]
Taxonomic identifier195103 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_1000021505

Sites

Binding site361Substrate; via amide nitrogen By similarity
Binding site1121ATP By similarity
Binding site1601ATP By similarity
Binding site1871Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0TQV3 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 0E3E82BF9B81CD59

FASTA26529,495
        10         20         30         40         50         60 
MEVLKRENPL IHMITNYVTV NDLAQVTINY GGLPLMATHH DELKEITKMA NGLLVNIGTL 

        70         80         90        100        110        120 
EPYQMESSMI SMKIAKEKGI PSVLDPVGVQ ASKLRKDFAK KLILEGEPSL IKGNLAEIKT 

       130        140        150        160        170        180 
LIGETSNSIG IDSFDDSLSE NTKNKIKEYA RERNLIVVVS GVVDFITNGE ESASVKNGTY 

       190        200        210        220        230        240 
KMSKITGTGC MLGALLTLAL SFYDHKDLRF KEVVKAVSTW GICGELAEER LREKEGLMTF 

       250        260 
KHNLLDELSI INDETIKERE KVIYD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000246 Genomic DNA. Translation: ABG83081.1.
RefSeqYP_695987.1. NC_008261.1.

3D structure databases

ProteinModelPortalQ0TQV3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING195103.CPF_1544.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG83081; ABG83081; CPF_1544.
GeneID4201531.
KEGGcpf:CPF_1544.
PATRIC19485348. VBICloPer106549_1494.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMALPLMATH.
OrthoDBEOG628F8M.
ProtClustDBPRK09355.

Enzyme and pathway databases

BioCycCPER195103:GHAW-1562-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM_CLOP1
AccessionPrimary (citable) accession number: Q0TQV3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways