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Q0TQV3

- THIM_CLOP1

UniProt

Q0TQV3 - THIM_CLOP1

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Protein
Hydroxyethylthiazole kinase
Gene
thiM, CPF_1544
Organism
Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361Substrate; via amide nitrogen By similarity
Binding sitei112 – 1121ATP By similarity
Binding sitei160 – 1601ATP By similarity
Binding sitei187 – 1871Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPER195103:GHAW-1562-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:CPF_1544
OrganismiClostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001823: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Hydroxyethylthiazole kinaseUniRule annotation
PRO_1000021505Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_1544.

Structurei

3D structure databases

ProteinModelPortaliQ0TQV3.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiAKPIMAE.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0TQV3-1 [UniParc]FASTAAdd to Basket

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MEVLKRENPL IHMITNYVTV NDLAQVTINY GGLPLMATHH DELKEITKMA    50
NGLLVNIGTL EPYQMESSMI SMKIAKEKGI PSVLDPVGVQ ASKLRKDFAK 100
KLILEGEPSL IKGNLAEIKT LIGETSNSIG IDSFDDSLSE NTKNKIKEYA 150
RERNLIVVVS GVVDFITNGE ESASVKNGTY KMSKITGTGC MLGALLTLAL 200
SFYDHKDLRF KEVVKAVSTW GICGELAEER LREKEGLMTF KHNLLDELSI 250
INDETIKERE KVIYD 265
Length:265
Mass (Da):29,495
Last modified:September 5, 2006 - v1
Checksum:i0E3E82BF9B81CD59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG83081.1.
RefSeqiYP_695987.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG83081; ABG83081; CPF_1544.
GeneIDi4201531.
KEGGicpf:CPF_1544.
PATRICi19485348. VBICloPer106549_1494.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG83081.1 .
RefSeqi YP_695987.1. NC_008261.1.

3D structure databases

ProteinModelPortali Q0TQV3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 195103.CPF_1544.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG83081 ; ABG83081 ; CPF_1544 .
GeneIDi 4201531.
KEGGi cpf:CPF_1544.
PATRICi 19485348. VBICloPer106549_1494.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi AKPIMAE.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci CPER195103:GHAW-1562-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13124 / NCTC 8237 / Type A.

Entry informationi

Entry nameiTHIM_CLOP1
AccessioniPrimary (citable) accession number: Q0TQV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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