Q0TQG5 (Q0TQG5_CLOP1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Uroporphyrinogen-III methyltransferase/synthase EMBL ABG84218.1
EC=2.1.1.107 EMBL ABG84218.1
EC=4.2.1.75 EMBL ABG84218.1

Gene names

Name:	hemD EMBL ABG84218.1
Ordered Locus Names:	CPF_1687

Organism

Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

195103 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the precorrin methyltransferase family. RuleBase RU003960

Ontologies

Keywords
Ligand	S-adenosyl-L-methionine SAAS SAAS014776
Molecular function	Lyase EMBL ABG84218.1 Methyltransferase SAAS SAAS006366 RuleBase RU003960 EMBL ABG84218.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	precorrin-2 dehydrogenase activity Inferred from electronic annotation. Source: InterPro uroporphyrin-III C-methyltransferase activity Inferred from electronic annotation. Source: EC uroporphyrinogen-III synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0TQG5 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: B9032CFE4B5BF4A1	FASTA	492	54,467
	10 20 30 40 50 60 MSKKAYIIGA GPGDEELLTL KAINALQKCT AVLYDRLVGN NILNYLNDDC EIYYCGKEPG 70 80 90 100 110 120 CHYKTQEEIN ESIVELAKKG HVVGRVKGGD PYVFGRGGEE VLALVEENIP FEVIPGVTSP 130 140 150 160 170 180 ISVLNYAGIP ITHRGLAQSF HIVTGMSART LNVNWKALSK ENGTLVFMMG LSNLETIVEK 190 200 210 220 230 240 LLENGKDIET PCGVVMRGTT SKQRKVIGTL ENICKKVREA KLESPCIIVV GDVVSLNEKL 250 260 270 280 290 300 SWYENLPLFG ANICLTRSKE QSKEIKWKLK ELGAEVTEIN SIKIKETAYN LDEYINTLEK 310 320 330 340 350 360 YDHIVFTSVN AVNVFFDYLV KNRVDIRKIK ADFAVLGKAT KKALIARGIV PSIMAHSFTA 370 380 390 400 410 420 EGLFEVLKDN IKEGEEVLIP CSSLSREYLF DNLASLGAKC HRVNIYDTIC GDVKNPRAFK 430 440 450 460 470 480 EVDMVLYTSP STVKNMIDMI GLEALKEKVS IAIGPITLKA LNESGIEGKM CKTHCGDGFL 490 SEIEGIWQEV KK

References

[1]

"Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens." Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Khouri H. , Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B., Paulsen I.T. Genome Res. 16:1031-1040(2006) [PubMed: 16825665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000246 Genomic DNA. Translation: ABG84218.1.
RefSeq	YP_696125.1. NC_008261.1.
3D structure databases
ProteinModelPortal	Q0TQG5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0TQG5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4202350.
GenomeReviews	Gene locus CPF_1687 in contig CP000246_GR.
KEGG	cpf:CPF_1687.
PATRIC	19485624. VBICloPer106549_1631.
TIGR	CPF_1687.
Phylogenomic databases
eggNOG	COG0007.
HOGENOM	HBG730212.
OMA	ETREMIK.
ProtClustDB	CLSK882291.
Family and domain databases
InterPro	IPR000878. 4pyrrol_Mease. IPR003754. 4pyrrol_synth_uPrphyn_synth. IPR014777. 4pyrrole_Mease_sub1. IPR014776. 4pyrrole_Mease_sub2. IPR006366. CobA_cysG_C. IPR003043. Uropor_MeTrfase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1010.10. 4pyrrole_Mease_sub1. 1 hit. G3DSA:3.30.950.10. 4pyrrole_Mease_sub2. 1 hit.
KO	K13542.
Pfam	PF02602. HEM4. 1 hit. PF00590. TP_methylase. 1 hit. [Graphical view]
SUPFAM	SSF53790. Cor/por_Metransf. 1 hit. SSF69618. HEM4_synth. 1 hit.
TIGRFAMs	TIGR01469. CobA_cysG_Cterm. 1 hit.
PROSITE	PS00839. SUMT_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q0TQG5_CLOP1

Accession

Primary (citable) accession number: Q0TQG5

Entry history

Integrated into UniProtKB/TrEMBL:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)