ID   BIOD_CLOP1              Reviewed;         228 AA.
AC   Q0TQ60;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=Dethiobiotin synthetase;
DE            EC=6.3.3.3;
DE   AltName: Full=Dethiobiotin synthase;
DE   AltName: Full=DTB synthetase;
DE            Short=DTBS;
GN   Name=bioD; OrderedLocusNames=CPF_1794;
OS   Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16825665; DOI=10.1101/gr.5238106;
RA   Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R.,
RA   DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C.,
RA   Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J.,
RA   Sullivan S.A., Khouri H., Dimitrov G.I., Watkins K.L., Mulligan S.,
RA   Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H.,
RA   Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I.,
RA   Melville S.B., Paulsen I.T.;
RT   "Skewed genomic variability in strains of the toxigenic bacterial
RT   pathogen, Clostridium perfringens.";
RL   Genome Res. 16:1031-1040(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + 7,8-diaminononanoate + CO(2) = ADP +
CC       phosphate + dethiobiotin.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis; biotin from
CC       6-carboxyhexanoyl-CoA: step 3/4.
CC   -!- SIMILARITY: Belongs to the dethiobiotin synthetase family.
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DR   EMBL; CP000246; ABG83122.1; -; Genomic_DNA.
DR   RefSeq; YP_696230.1; -.
DR   GeneID; 4202332; -.
DR   GenomeReviews; CP000246_GR; CPF_1794.
DR   KEGG; cpf:CPF_1794; -.
DR   TIGR; CPF_1794; -.
DR   HOGENOM; Q0TQ60; -.
DR   OMA; Q0TQ60; KGVFITA.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004141; F:dethiobiotin synthase activity; IEA:HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0009102; P:biotin biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00336; -; 1.
DR   InterPro; IPR004472; BioD_synth.
DR   PIRSF; PIRSF006755; DTB_synth; 1.
DR   TIGRFAMs; TIGR00347; bioD; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Biotin biosynthesis; Complete proteome; Ligase;
KW   Magnesium; Nucleotide-binding.
FT   CHAIN         1    228       Dethiobiotin synthetase.
FT                                /FTId=PRO_0000302499.
FT   NP_BIND       9     17       ATP (By similarity).
SQ   SEQUENCE   228 AA;  25555 MW;  03D45C5E3F5CB12F CRC64;
     MEKGVYIIGT STDIGKTFIS GLILKKLREE GRNAGYYKAV LSGAIKDKKG LIPLDCEEVM
     EISGLKESYE NMVSYILENP YSPHLASEVE EVSISMEKIK KDYKSVRDKY DFILCEGSGG
     IVCPISFSEK KLMLEDIIKE FNLPIILVSN SGLGAINHTV LTVSYLRNLG LKVKGIILNK
     FNKSDIIHRD NKKIIKELTG VNNISTVPKI EDIEKYDLNE LNEVLYGI
//