Q0TPZ6 (MSRB_CLOP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	CPF_1860

Organism

Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

195103 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	147 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 147	147	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_1000068266
Sites
	Active site	120	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0TPZ6 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: B2290C2ACCD4654B	FASTA	147	17,118
	10 20 30 40 50 60 MKYTKKEKEE LKKVLTEEEY YVTQENGTER PFTNEYWDFN GEGIYVDITT GEPLFTSKDK 70 80 90 100 110 120 FHSSCGWPAF SKPIDRSIIK EKVDKSHGMI RTEVRSKLGD SHLGHVFCDG PEELGGLRYC 130 140 INSASLKFIP KEELKEKGYE EYLELFK

References

[1]

"Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens." Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Khouri H. , Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B., Paulsen I.T. Genome Res. 16:1031-1040(2006) [PubMed: 16825665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13124 / NCTC 8237 / Type A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000246 Genomic DNA. Translation: ABG83302.1.
RefSeq	YP_696294.1. NC_008261.1.
3D structure databases
ProteinModelPortal	Q0TPZ6.
SMR	Q0TPZ6. Positions 8-146.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0TPZ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4202592.
GenomeReviews	Gene locus CPF_1860 in contig CP000246_GR.
KEGG	cpf:CPF_1860.
PATRIC	19485974. VBICloPer106549_1806.
TIGR	CPF_1860.
Phylogenomic databases
eggNOG	COG0229.
HOGENOM	HBG715255.
OMA	FTDGPVD.
ProtClustDB	PRK00222.
Enzyme and pathway databases
BioCyc	CPER195103:CPF_1860-MONOMER.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_CLOP1

Accession

Primary (citable) accession number: Q0TPZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program